Construction of DNA replication stress gene related risk model and for prognosis in bladder cancer DOI
Hao Xie, Jiahao Guo,

Yufan Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Bladder cancer (BLCA) remains a widespread and serious globally. The importance of constructing predictive risk models based on DNA replication stress-related genes (DRSGs) is gaining traction. Despite the scarcity molecular studies, our analysis Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets led to identification 17 DEDRSGs with prognostic significance, primarily involved in cell cycle control. Subsequently, utilizing LASSO regression, we filtered out nine key biomarkers develop model that effectively distinguishes immunological profiles GSVA hallmark pathways across strata. Besides, significant differences were observed distribution 191 drugs two groups. Finally, qRT-PCR was performed confirmed BUB1B significantly highly expressed 5637 cells line, while expression level RAD9A higher SV-HUC-1 line. In conclusion, model, biomarkers, offers theoretical framework for exploring underlying mechanisms BLCA.

Language: Английский

A comprehensive review on targeting diverse immune cells for anticancer therapy: beyond immune checkpoint inhibitors DOI Creative Commons
Dequan Liu, Lei Liu, Xinming Zhao

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 210, P. 104702 - 104702

Published: March 22, 2025

Although immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, primary resistance and acquired continue to limit their efficacy for many patients. To address enhance the anti-tumor activity within tumor microenvironment (TIME), numerous therapeutic strategies targeting both innate adaptive cells emerged. These include combination therapies with ICIs, chimeric antigen receptor T-cell (CAR-T), macrophages (CAR-Ms) or natural killer cell (CAR-NK) therapy, colony stimulating factor 1 (CSF1R) inhibitors, dendritic (DC) vaccines, toll-like (TLR) agonists, cytokine therapies, chemokine inhibition. approaches underscore significant potential of TIME in treatment. This article provides a comprehensive up-to-date review mechanisms action various TIME, as well each type, aiming deepen understanding potential.

Language: Английский

Citations

0
The duality of GSK-3β in urinary bladder cancer: Tumor suppressor and promoter roles through multiple signaling pathways DOI

Zufa Sabeel,

Jianfeng Wang,

Jian Dong

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189324 - 189324

Published: April 1, 2025

Language: Английский

Citations

0
Bioinformatics analysis reveals CTSF suppresses tumor cell malignant phenotype and CD8 + T cell exhaustion by downregulating Bcl- 2 protein in the microenvironment of bladder cancer DOI
Dan Gao,

Jian Yin,

Peng Tie

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Heterogeneity of modulatory immune microenvironment in bladder cancer DOI

Enas El Saftawy,

Basma Emad Aboulhoda, Mansour A. Alghamdi

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102679 - 102679

Published: Dec. 12, 2024

Language: Английский

Citations

1
Construction of DNA replication stress gene related risk model and for prognosis in bladder cancer DOI
Hao Xie, Jiahao Guo,

Yufan Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Bladder cancer (BLCA) remains a widespread and serious globally. The importance of constructing predictive risk models based on DNA replication stress-related genes (DRSGs) is gaining traction. Despite the scarcity molecular studies, our analysis Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets led to identification 17 DEDRSGs with prognostic significance, primarily involved in cell cycle control. Subsequently, utilizing LASSO regression, we filtered out nine key biomarkers develop model that effectively distinguishes immunological profiles GSVA hallmark pathways across strata. Besides, significant differences were observed distribution 191 drugs two groups. Finally, qRT-PCR was performed confirmed BUB1B significantly highly expressed 5637 cells line, while expression level RAD9A higher SV-HUC-1 line. In conclusion, model, biomarkers, offers theoretical framework for exploring underlying mechanisms BLCA.

Language: Английский

Citations

0