American Journal of Obstetrics & Gynecology MFM, Journal Year: 2024, Volume and Issue: unknown, P. 101578 - 101578
Published: Dec. 1, 2024
Language: Английский
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 18, 2025
Abstract Cardiovascular diseases are the leading causes of death worldwide. However, there still shortcomings in currently employed treatment methods for these diseases. Therefore, exploring molecular mechanisms underlying cardiovascular is an important avenue developing new strategies. Previous studies have confirmed that metabolic and epigenetic alterations often involved across patients. Moreover, factors interact with each other affect progression a coordinated manner. Lactylation novel posttranslational modification (PTM) links metabolism epigenetics affects disease progression. analyzing crosstalk between cellular expected to provide insights development The purpose this review describe relationship heart such as failure, myocardial infarction, atherosclerosis, focus on acylation methylation, propose potential therapeutic measures.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 9, 2025
The role of oxidative stress in vascular surgical diseases has increasingly been recognized as significant. This paper systematically reviews the specific mechanisms a various condition, including aortic dissection, abdominal aneurysm, thrombosis, diabetic foot, and thromboangiitis obliterans, while also exploring related therapeutic strategies. Oxidative arises from an imbalance between free radicals antioxidants, where excess reactive oxygen species other can exacerbate inflammatory response. delves into pathogenic aforementioned discusses potential methods for utilizing antioxidants to reduce levels. Additionally, this highlights challenges faced by current antioxidant therapies identifies future research directions. By summarizing progress, aims provide theoretical basis more effective treatment strategies diseases, with hope advancing field.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 640 - 640
Published: April 25, 2025
Alveolar macrophages (AMs) are immune cells located in the alveoli-the tiny air sacs lungs where gas exchange occurs. Their functions regulated by various epigenetic mechanisms, which essential for both healthy lung function and disease development. In lung's microenvironment, AMs play critical roles surveillance, pathogen clearance, tissue repair. This review examines how regulation influences AM their involvement diseases. Key such as DNA methylation, histone modifications, non-coding RNAs, regulate gene expression response to environmental signals. lungs, these modifications enable quickly respond inhaled threats. However, when processes malfunction, they could contribute diseases pulmonary fibrosis, COPD, hypertension. By exploring changes affect polarization, plasticity, responses, we can gain deeper insights into role open new avenues treating preventing respiratory conditions. Ultimately, understanding mechanisms within enhances our knowledge of immunology offers potential innovative interventions restore health prevent
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 295, P. 117790 - 117790
Published: May 20, 2025
Language: Английский
Citations
0
American Journal of Obstetrics & Gynecology MFM, Journal Year: 2024, Volume and Issue: unknown, P. 101578 - 101578
Published: Dec. 1, 2024
Language: Английский
Citations
0