The brainstem reticular formation pivots abnormal neural transmission in the course of Anorexia Nervosa
Journal of Neural Transmission,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Language: Английский
Active vitamin D corrects cerebrovascular dysfunction and aberrant vasopressin expression in the hypertension phenotype of 1α-hydroxylase knockout mice
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 7, 2024
Abstract
Background
Under
hypertensive
conditions,
vitamin
D
has
a
protective
effect
on
the
brain.
Our
previous
research
showed
that
1,25-dihydroxyvitamin
D
3
[1,25(OH)
2D
3]
negatively
regulates
hypertension
and
central
renin–angiotensin
system
activation
partly
through
antioxidative
mechanism
in
1α-hydroxylase
knockout
[1α(OH)ase
–/–]
mice.
To
further
confirm
whether
endogenous
1,25(OH)
2D
3
deficiency
exogenous
supplementation
alter
cerebrovascular
function
vasopressin
expression
antioxidation,
we
provided
1α(OH)ase
–/–
mice
their
wild-type
littermates
with
normal
diet;
high-calcium,
high-phosphorus
rescue
diet
N-acetyl-l-cysteine
supplementation;
or
subcutaneous
injection.
We
analysed
compared
changes
arterial
blood
pressure,
brain
microvessel
reactivity,
cerebral
flow,
of
hypothalamic
vasopressin,
brain/blood
oxidation
indices
using
caudal
artery
plethysmography,
isolated
pressure
myographs,
laser
Doppler
flowmetry,
immunohistochemistry,
western
blot
biochemistry.
Results
Compared
littermates,
phenotype
was
present
mice,
paraventricular
nucleus
supraoptic
significantly
upregulated,
posterior
reaction
to
vasodilatory
acetylcholine
vasoconstrictive
nitric
oxide
synthase
inhibitor
L-nitro-arginine
decreased.
Brain/blood
oxidative
stress
increased,
but
parameters
were
These
pathologic
corrected
by
plus
diet.
Conclusions
our
findings
indicate
an
inhibitory
dysfunction.
may
be
promising
intervention
reduce
impaired
induced
Language: Английский
Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease.
Wen Cheng,
No information about this author
Kexin Fang,
No information about this author
Xiaorong Ouyang
No information about this author
et al.
Neurochemistry International,
Journal Year:
2024,
Volume and Issue:
180, P. 105871 - 105871
Published: Oct. 1, 2024
Language: Английский