Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114405 - 114405

Published: March 13, 2025

Language: Английский

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Gompertz law based biological age (GOLD BioAge): a simple and practical measurement of biological aging to capture morbidity and mortality risks

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Biological age reflects actual aging and overall health, but current clocks are often complex difficult to interpret, limiting their clinical application. In this study, we introduced a Gompertz law-based biological (GOLD BioAge) model that simplified assessment. We estimated GOLD BioAge using biomarkers found significant associations of the difference from chronological (BioAgeDiff) with risks morbidity mortality in NHANES. Moreover, developed ProtAge MetAge proteomics metabolomics data, which outperformed clinical-only predicting chronic disease UK Biobank. Benchmark analysis illustrated our models exceeded common across diverse groups both NHANES The results demonstrated algorithm effectively applied omics showing excellent performance age-related outcomes. Additionally, created version called Light BioAge, used three for reliably captured validation cohorts (CHARLS, RuLAS, CLHLS). It significantly predicted onset frailty, stratified frail individuals, collectively identified individuals at high risk mortality. summary, could provide valuable framework assessment public health practice. Highlights law based was proposed construct convenient interpretable calculations, had better risks. Our approach applicable metabolomics, yielding great prospect improve accuracy prevent diseases. version, biomarkers, it independently cohorts. BioAgeDiff

Language: Английский

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Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Aging to Capture Morbidity and Mortality Risks

Published: Nov. 27, 2024

Biological age reflects actual aging and overall health, but current clocks are often complex difficult to interpret, limiting their clinical application. In this study, we introduced a Gompertz law-based biological (GOLD BioAge) model that simplified assessment. We estimated GOLD BioAge using biomarkers found significant associations of the difference from chronological (BioAgeDiff) with risks morbidity mortality in NHANES. Moreover, developed ProtAge MetAge proteomics metabolomics data, which outperformed clinical-only predicting chronic disease UK Biobank. Benchmark analysis illustrated our models exceeded common across diverse groups both NHANES The results demonstrated algorithm effectively applied omics showing excellent performance age-related outcomes. Additionally, created version called Light BioAge, used three for reliably captured validation cohorts (CHARLS, RuLAS, CLHLS). It significantly predicted onset frailty, stratified frail individuals, collectively identified individuals at high risk mortality. summary, could provide valuable framework assessment public health practice.

Language: Английский

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Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Aging to Capture Morbidity and Mortality Risks

Published: Jan. 1, 2024

Language: Английский

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