Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study DOI Creative Commons

Hua Yang

Polish Journal of Microbiology, Journal Year: 2024, Volume and Issue: 73(4), P. 491 - 503

Published: Dec. 1, 2024

Abstract Epidemiological studies and animal models have suggested a possible link between gut microbiota (GM), circulating metabolites, endometriosis (EMs) pathogenesis. However, whether these associations are causal or merely due to confounding factors remains unclear. We conducted two-sample two-step Mendelian randomization (MR) study elucidate the potential relationship GM EMs, mediating role of metabolites. Our MR analysis revealed that higher abundances class Negativicutes, order Selenomonadales, as well genera Dialister, Enterorhabdus, Eubacterium xylanophilum group, Methanobrevibacter were associated with an increased risk EMs (Odds Ratio (OR) range: 1.0019–1.0037). Conversely, Coprococcus 1 Senegalimassilia linked reduced (OR 0.9964–0.9967). Additionally, elevated levels metabolites such 1-eicosatrienoyl-glycerophosphocholine 1-oleoylglycerophosphocholine found be heightened 2.21–3.16), while concentrations 3-phenylpropionate dihomo-linolenate protective 0.285–0.535). Two-step indicated specific microbial taxa, notably genus Enterorhabdus might function mediators linking EMs. findings suggest probable GM, indicating may mediate influence on pathophysiology These results offer new leads for future mechanistic could inform clinical translational research.

Language: Английский

Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

9
Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective DOI Creative Commons
Fang Liu, Cui Guo, Xue Liu

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 126 - 126

Published: Feb. 14, 2025

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that may progress to colorectal cancer (CRC), presenting significant challenges global health. With shifts in lifestyle, the incidence of both conditions continues rise, underscoring urgent need for effective treatments. While traditional therapies can be effective, their high recurrence rates and associated adverse reactions limit broader application. Luteolin, flavonoid derived from natural plants, has emerged as promising focus IBD CRC research due its multi-target therapeutic potential. This article reviews molecular mechanisms signaling pathways through which luteolin regulates immune cell differentiation, mitigates inflammation oxidative stress, modulates gut microbiota, restores mucosal barrier function IBD. In context CRC, demonstrates anti-tumor effects by inhibiting proliferation, inducing apoptosis, suppressing migration invasion. Notably, demonstrated improvements symptoms influencing differentiation T subsets, decreasing expression mediators, activating antioxidant pathways, enhancing structure microbiota. Furthermore, advancements formulation technology, such use polymer micelles responsive nanoparticles, have greatly improved bioavailability efficacy luteolin. However, further investigation needed address potential toxicity luteolin, particularly critical transition CRC. emphasizes treatment anticipates prospects future clinical applications agent.

Language: Английский

Citations

0
Comprehensive multifaceted approach in antibody therapeutics: targeting gut dysbiosis and gastrointestinal oncogenic cells DOI

Uddipta Guha

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Language: Английский

Citations

0
The emerging role of honeysuckle flower in inflammatory bowel disease DOI Creative Commons

P. De Muro,

Caihong Jing,

Zhihan Zhao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues rise developing countries. Nonetheless, the existing therapies for have limitations fail address needs patients thoroughly. There is an increasing need new, safe, highly effective alternative medications patients. Traditional Chinese Medicine (TCM) employed drug development management due its wide-range biological activities, minimal toxicity, limited side effects. Extensive research has shown certain TCM exhibits significant therapeutic benefits treatments. Honeysuckle (Lonicera japonica) was used clinical settings IBD. Bioactive metabolites L. japonica, such luteolin, quercetin, cyanidin, chlorogenic acid (CGA), caffeic (CA), saponin, exhibit managing honeysuckle flower a potential candidate anti-inflammatory, immune system-regulating, antioxidant qualities. This paper reviews It discusses fundamental mechanism japonica bioactive prevention

Language: Английский

Citations

0
Flavonoides en la dieta, perspectivas en la regulación de la inflamación intestinal DOI Creative Commons
Óscar Nieto-Yáñez, Sonia E. Hernández Navia, Betsaida J. Ortiz‐Sánchez

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 28

Published: April 23, 2025

La colitis ulcerativa (CU) es una enfermedad inflamatoria crónica del intestino que se manifiesta con dolor abdominal, daño tisular, acortamiento colon, pérdida de peso, diarrea y sangrado; un factor riesgo para el desarrollo cáncer colorrectal. Sin embargo, cuando reduce la inflamación colon aminoran los signos síntomas esta afección, incluso en etapas tempranas detiene revierte su desarrollo. Los tratamientos antiinflamatorios naturales, sin efectos colaterales bajo costo, son ventana oportunidad países economías emergentes. flavonoides grupo polifenoles presentes plantas frutas, algunos ellos utilizados medicina tradicional atenuar (colitis) otros padecimientos. acción, mecanismos farmacológicos este compuestos amplio espectro al intervenir regulación las poblaciones microbiota protección contra estrés oxidativo, preservación función barrera epitelial, así como, propiedades inmunomoduladoras. En revisión mencionan principales forman parte dieta. Describimos sus reguladores contrastamos evasión inmunológica colorrectal asociado a colitis.

Citations

0
Application of Response Surface Methodology to Design and Optimize Purification of Acetone or Aqueous Acetone Extracts of Hop Cones (Humulus lupulus L.) Using Superparamagnetic Iron Oxide Nanoparticles for Xanthohumol Isolation DOI Open Access

Natalia Żuk,

Sylwia Pasieczna‐Patkowska, Jolanta Flieger

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(19), P. 4827 - 4827

Published: Sept. 30, 2024

Iron oxide nanoparticles (IONPs) are an ideal sorbent for magnetic dispersion extraction due to their superparamagnetic properties and developed active surface. This work aims use IONPs, obtained by chemical co-precipitation, purify 100% acetone 50% extracts from hop cones (Humulus lupulus L.) ultrasonic-assisted solvent extraction. The were purified bitter acids (i.e., humulones, lupulones) isolate xanthohumol. sorption conditions optimized depending on the composition of mixture, specifically mass IONPs time needed achieve effective using response surface methodology (RSM). An analysis variance (ANOVA) was performed assess adequacy model, a good agreement found between experimental data proposed model. polynomial equation describing model is highly significant (p < 0.05), with precision Adeq (above 4). indicates usefulness regression prediction in design. final products purification contain 40.58 ± 2.84 µg mL-1 57.64 0.83 xanthohumol, respectively. extract provides more favorable smaller amount required higher recovery development reliable multivariate allowed optimization process, resulting high-purity xanthohumol natural sources.

Language: Английский

Citations

2
Eriocalyxin B ameliorated experimental autoimmune prostatitis via modulation of macrophage polarization through gut microbiota-mediated vitamin D3 alteration DOI Creative Commons
Zhifeng Yu, Hexi Du, Shan Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156191 - 156191

Published: Nov. 1, 2024

Language: Английский

Citations

1
Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study DOI Creative Commons

Hua Yang

Polish Journal of Microbiology, Journal Year: 2024, Volume and Issue: 73(4), P. 491 - 503

Published: Dec. 1, 2024

Abstract Epidemiological studies and animal models have suggested a possible link between gut microbiota (GM), circulating metabolites, endometriosis (EMs) pathogenesis. However, whether these associations are causal or merely due to confounding factors remains unclear. We conducted two-sample two-step Mendelian randomization (MR) study elucidate the potential relationship GM EMs, mediating role of metabolites. Our MR analysis revealed that higher abundances class Negativicutes, order Selenomonadales, as well genera Dialister, Enterorhabdus, Eubacterium xylanophilum group, Methanobrevibacter were associated with an increased risk EMs (Odds Ratio (OR) range: 1.0019–1.0037). Conversely, Coprococcus 1 Senegalimassilia linked reduced (OR 0.9964–0.9967). Additionally, elevated levels metabolites such 1-eicosatrienoyl-glycerophosphocholine 1-oleoylglycerophosphocholine found be heightened 2.21–3.16), while concentrations 3-phenylpropionate dihomo-linolenate protective 0.285–0.535). Two-step indicated specific microbial taxa, notably genus Enterorhabdus might function mediators linking EMs. findings suggest probable GM, indicating may mediate influence on pathophysiology These results offer new leads for future mechanistic could inform clinical translational research.

Language: Английский

Citations

0