Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 25, 2024
Many patients experience persistent symptoms after COVID-19, a syndrome referred to as Long COVID (LC). The goal of this study was identify novel new or worsening comorbidities self-reported in with LC.
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1634 - 1634
Published: Feb. 14, 2025
Aging and age-related neurodegenerative disorders are characterized by the dysfunction or loss of brain nicotinic acetylcholine receptors (nAChRs), these changes may be related to other senescence markers, such as oxidative stress DNA repair dysfunction. However, mechanism nAChR in aging modification this process drugs (e.g., memantine, Mem) not yet fully understood. To study whether differences expression rat occur due modulated Mem, we analyzed subunits (at RNA protein levels) biomarkers real-time quantitative polymerase chain reaction (RQ-PCR) Western blot validation. Twenty-one female Wistar rats were divided into four groups, depending on age, oldest group received injections Mem water with use intragastric catheters. We studied cerebral grey matter (CGM), subcortical white (SCWM), cerebellum (Ce). Results showed an decrease α7 mRNA level SCWM. The was accompanied reduced 8-oxoguanine glycosylase 1 (OGG1) increased tumor necrosis factor alpha (TNFα) level. In group, observed a higher SCWM Ce. Biomarker levels changed, but different extent area. Importantly, antioxidative status stopped even regressed under treatment. After two weeks treatment, increase TP53 8-oxo-2'deoxyguanosine (8-oxo-2'dG) observed. conclude that administration protective against mechanisms.
Language: Английский
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Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108827 - 108827
Published: Feb. 1, 2025
Language: Английский
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Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137246 - 137246
Published: March 4, 2025
Language: Английский
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Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113832 - 113832
Published: March 1, 2025
Language: Английский
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Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405
Published: March 12, 2025
Background: The Zika virus (ZIKV) is an arbovirus linked to “Congenital Syndrome” and a range of neurodevelopmental disorders (NDDs), with microcephaly as the most severe manifestation. Milder NDDs, such autism spectrum delays in neuropsychomotor language development, often go unnoticed neonates, resulting long-term social academic difficulties. Murine models ZIKV infection can be used mimic part motor cognitive deficits observed humans. These evaluated through behavioral tests, enabling comparison gene expression profiles aiding characterization ZIKV-induced NDDs. Objectives: This study aimed identify genes associated changes following subtle juvenile BALB/c mice. Methods: Neonatal mice were subcutaneously inoculated (MH544701.2) on postnatal day 1 (DPN) at dose 6.8 × 103 PFU. Viral presence cerebellum cortex was quantified 10- 30-days post-infection (DPI) using RT-qPCR. Neurobehavioral assessed 30 DPI T-maze, rotarod, open field tests. Next-Generation Sequencing (NGS) performed differentially expressed (DEGs), which analyzed Gene Ontology (GO) KEGG enrichment. interaction networks then constructed explore interactions enriched biological categories. Results: A model successfully established, brain while allowing survival beyond DPI. induced mild changes, though motivational functions remained unaffected. functional repression synaptic vesicles alterations neuronal structure, suggesting potential disruptions plasticity. Conclusions: Moderate circulating strains from 2016 epidemic may cause dysregulation related immune response, cytoskeletal organization, modifications cellular transport mediated by vesicles. Despite viral control, neurocognitive effects persisted, including memory anxiety-like behaviors, highlighting neurological consequences that show no apparent malformations.
Language: Английский
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Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 19, 2025
Currently, the treatment and prevention of multiple sclerosis (MS) continue to encounter significant challenges. Mendelian randomization (MR) analysis has emerged as a crucial research method in pursuit new therapeutic strategies. Accordingly, we hypothesize that there exists causal association between genetic variants specific plasma proteins MS through MR mechanisms, key targets can be precisely identified by integrating multi-omics analytical approaches. In this study, developed comprehensive framework aimed at identifying validating potential for MS. The commenced with two-sample study utilizing two large protein quantitative trait locus (pQTL) datasets. Building on foundation, performed Bayesian co-localization coding genes, followed full phenotype-wide (PheWAS) co-positive genes both methods. This approach allowed us explore functions mechanisms co-morbidity associated disease. Subsequently, integrated protein-protein interaction (PPI) network analysis, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway facilitate drug prediction molecular docking studies. conducted systematic pQTLs datasets Icelandic 88 positive proteins, while UK Biobank database 122 proteins. By comparison, uroporphyrinogen III synthase (UROS) glutathione S-transferase theta 2B (GSTT2B) were found shared After false discovery rate (FDR) correction, signal transducer activator transcription 3 (STAT3) was significantly pQTLs. pQTLs, advanced glycosylation end product-specific receptor (AGER), allograft inflammatory factor 1 (AIF1), butyrophilin subfamily member A1 (BTN1A1), cluster differentiation 58 (CD58), desmoglein 4 (DSG4), ecotropic viral integration site 5 (EVI5), tumor necrosis (TNF), superfamily 14 (TNFRSF14) Bonferroni AGER, CD58, EVI5, TNF remained colocalization EVI5 (PPH4 = 0.9800), O-GlcNAcase (OGA) 0.8569), TNFRSF14 0.8904) common conclusion, OGA, may Through application have successfully These findings provide scientific basis development novel immunotherapies, combination regimens, or targeted intervention
Language: Английский
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Genomics, Journal Year: 2025, Volume and Issue: 117(3), P. 111033 - 111033
Published: March 22, 2025
Language: Английский
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Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537
Published: March 1, 2025
Language: Английский
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International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114721 - 114721
Published: April 28, 2025
Language: Английский
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Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 26, 2024
Mast cells serve as crucial effector within the innate immune system and are predominantly localized in skin, airways, gastrointestinal tract, urinary reproductive tracts, well brain. Under physiological conditions, brain-resident mast secrete a diverse array of neuro-regulatory mediators to actively participate neuroprotection. Meanwhile, primary source molecules causing brain inflammation, also function “first responders” injury. They interact with neuroglial neurons facilitate release numerous inflammatory mediators, proteases, reactive oxygen species. This process initiates amplifies immune-inflammatory responses brain, thereby contributing regulation neuroinflammation blood-brain barrier permeability. article provides comprehensive overview potential mechanisms through which may modulate neuroprotection their pathological implications various neurological disorders. It is our contention that inhibition cell activation disorders could represent novel avenue for therapeutic breakthroughs.
Language: Английский
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