Acute toxicity and hepatoprotective effect of Arum maculatum on rat liver cirrhosis induced with thioacetamide

Acta Pharmaceutica, Journal Year: 2025, Volume and Issue: 75(1), P. 87 - 102

Published: March 1, 2025

Abstract Arum maculatum is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate hepatoprotective impacts ethanolic extract A. leaves on cirrhosis induced by thioacetamide (TAA) Sprague--Dawley rats. rats were treated two months with administered intraperitoneally thrice weekly. Histopathological examination revealed severe damage control group, while silymarin treatments ( p < 0.05). Furthermore, treatment led normalization pro-inflammatory cytokines TNF-α and IL-6, increased expression anti-inflammatory cytokine IL-10 Thus, might have role rat TAA, along antioxidant effects.

Language: Английский

Protective effect of hydroxysafflor yellow a on thioacetamide-induced liver injury and osteopenia in zebrafish

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 117109 - 117109

Published: Sept. 1, 2024

Language: Английский