Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells DOI Creative Commons
Ziqin Chen,

Nianqi Xiao,

Lan Luo

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 3, 2024

The recent development of nanobiomaterials has shed some light on the field periodontal tissue regeneration. Laponite (LAP), an artificially synthesized two-dimensional (2D) disk-shaped nanosilicate, garnered substantial attention in regenerative biomedical applications owing to its distinctive structure, exceptional biocompatibility and bioactivity. This study endeavors comprehensively evaluate influence LAP effects ligament cells (PDLCs) osteogenesis, cementogenesis angiogenesis were systematically assessed, potential mechanism was explored through RNA sequencing. results indicated that improved osteogenic cementogenic differentiation PDLCs, regulatory PDLCs closely correlated with activation PI3K-AKT signaling pathway. Moreover, enhanced indirectly via manipulating paracrine PDLCs. Then, implanted into rat defect confirm potential. Both micro-CT histological analysis could facilitate regeneration vivo. These findings provide insights bioactivity underlying highlighting it might be a therapeutic option therapy.

Language: Английский

Hybrid silver-graphene nanoparticles enhanced Lauric Acid phase change material for photovoltaic and thermoelectric generator applications: Experimental and simulation analysis DOI
Yasir Ali Bhutto, A.K. Pandey, R. Saidur

et al.

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 93, P. 112320 - 112320

Published: June 3, 2024

Language: Английский

Citations

19
Syzygium aromaticum Bud Extracted Core–Shell Ag–Fe Bimetallic Nanoparticles: Phytotoxic, Antioxidant, Insecticidal, and Antibacterial Properties DOI Creative Commons
Farah Murtaza, Naseem Akhter, Muhammad Azam Qamar

et al.

Crystals, Journal Year: 2024, Volume and Issue: 14(6), P. 510 - 510

Published: May 27, 2024

Today, there is the roar of sustainable material development around globe. Green nanotechnology one extensions sustainability. Due to its approach, green fabrication nanoparticles has recently surpassed their classical synthesis in popularity. Among metal nanoparticles, contemporary findings have demonstrated that bimetallic possess more potential for different applications than monometallic due synergistic effects two metals. So, we are presenting facile, one-vessel, and one-step phyto-fabrication Ag–Fe BMNPs using bud extract Syzygiumaromaticum. The synthesized were characterized by UV-VIS, XRD, EDX, FTIR, SEM. NPs underwent biological studies. radical scavenging was found be 64% 73%, insecticidal 80% 100%, respectively. Similarly, both exhibited good antibacterial activity. zone inhibition 100 mg/mL 1 cm against all bacterial species, i.e., K. pneumonia, E. coli, S. aureus. It 1.5 cm, 1.3 aureus, respectively, showing activity higher NPs. this study unlocks eco-safe, cost-effective, least-harmful methodology with SA medical agricultural fields, a step towards

Language: Английский

Citations

5
Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment DOI Creative Commons

Mingchuan Yang,

Yufeng He,

Qingqing Ni

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 972 - 972

Published: July 23, 2024

Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting function, yet their structural instability low bioavailability hinder utility. To overcome this challenge, researchers have utilized the inherent physical chemical characteristics of derivatives to develop innovative nanomedicines targeting mitochondria. This review examines construction strategies properties various types polyphenol-based biological nanomedicine regulating mitochondria in recent years, such as polyphenol self-assembly, metal–phenol network, polyphenol–protein, polyphenol–hydrogel, polyphenol–chitosan, polyphenol–liposome. These polyphenolic incorporate enhanced features improved solubility, efficient photothermal conversion capability, regulation homeostasis, ion adsorption through diverse strategies. focus is how these promote ROS production mechanism inhibit cancer. Furthermore, it delves into benefits applications treatments, well challenges future research.

Language: Английский

Citations

4
Preparation of Diosgenin-Functionalized Gold Nanoparticles: From Synthesis to Antitumor Activities DOI Open Access
Elżbieta U. Stolarczyk, Weronika Strzempek, Magdalena Muszyńska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1088 - 1088

Published: Jan. 27, 2025

Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing effectiveness therapeutic diagnostic approaches in cancer treatment. Our study presents a promising strategy applying thiocompound nanomedicine therapy. first aimed to investigate biological properties new compound thiodiosgenin (TDG)—a derivative diosgenin—a natural with known antioxidant anticancer properties. current second compare efficacy diosgenin—functionalized gold nanoparticles—with its precursor on prostate (DU-145) cell lines. Moreover, safety thio-derivative conjugates was tested against human epithelial line PNT-2. New advanced analytical techniques were developed characterization nanomaterials using methods such as SP-ICP-MS, UV-Vis, TEM, NMR, FT-IR ELS, TGA. synthetic approach based, one hand, ligand exchange citrates (TDG) nanoparticles, other attachment DG through an ester bond linker, which 3-mercaptopropionic acid (MPA) nanoparticles. Initial vitro studies indicate that TDG shows greater cytotoxic effects cells but poses risks normal (PNT-2). It demonstrated all produced exhibited significant while being less harmful (PNT-2) compared itself. All obtained showed antitumor properties; however, targeted transport, system referred AuNPs-MPAm1-DG is promising, due size nanoparticles 53 nm, zeta potential -30 mV, loading content 27.6%. synthesizing diosgenin optimized medical applications. Advanced methodologies characterize conjugates, particularly use solve existing differences shape morphology surface conjugates.

Language: Английский

Citations

0
Synthesis of SrAl2O4 and MgCoO2 bimetallic inorganic nanomaterials for thermal and electrochemical applications DOI Creative Commons
Arunkumar Lagashetty,

B. J. Girija,

H. Mohana

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 11, 2025

Bimetallic inorganic nanoparticles are vital due to their high biocompatibility, stability and comparatively less toxicity. Nanosized bimetallic oxide materials have been extensively studied worldwide unique properties such as electrical, magnetic mechanical properties. Present work is reporting the size-controlled synthesis of strontium aluminate magnesium cobaltate (SrAl2O4 MgCoO2) by self-propagating combustion reaction using polymer fuel. Size prepared SrAl2O4 MgCoO2 samples distributed on DLS spectrum was 76 nm 100 respectively. The structural morphological characterization nano were carried out X-ray diffraction (XRD) scanning electron microscope (SEM) analysis It shows crystalline compact nature samples. FT-IR instrumentation used study bonding both Formation metal metal–metal can supports sample formation. EDX further confirm presence Sr, Al, Mg Co metals also characteristics absorption peaks signals demonstrate final phases UV–vis spectroscopic fluorescence undertaken know emission behaviour In continuation, thermal electrochemical studies analyzed. Thermal investigation assesses samples, which stability. preliminary results CV concluding that, electro active show possible applications. insights gained from this contribute growing body knowledge in nanomaterials pave way for innovations electrical thermal-related technologies.

Language: Английский

Citations

0
Engineering of thermal energy storage: An experimental study of organic/silver and organic/silver-coconut shell biochar composite phase change materials DOI
Reji Kumar Rajamony,

B. Kalidasan,

A.G.N. Sofiah

et al.

Thermal Science and Engineering Progress, Journal Year: 2025, Volume and Issue: unknown, P. 103639 - 103639

Published: May 1, 2025

Language: Английский

Citations

0
Fabrication of chitosan-coated ciprofloxacin drug nanocomposite for combating antibacterial and respiratory infection leading to sepsis DOI
Haoguang Li,

Zhiguo Su

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

0
Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings DOI Creative Commons
Menglei Wang,

Yawen Luo,

Qianwen Yang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2813 - 2846

Published: March 1, 2025

Abstract: Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, due to their unique structures, high bioactivities, excellent designability characteristics, an increasing number of studies been devoted modifying these species generate novel composites with desirable optical, electrical, magnetic properties. However, few systematic detailed reviews performed relating the modification approaches available MNPs resulting composites. In this review, a comprehensive summary is regarding optimized formulations application dressings, techniques used prepare composite dressings are discussed. addition, safety profiles nanocomposite limitations reported systems evaluated. More importantly, solution strategies proposed address limitations. Overall, review provides new ideas design facilitate field skin repair, also looks into future direction biomedical field. Keywords: metal-based nanoparticles, nanocomposite, dressing, multi-functional,

Language: Английский

Citations

0
Cellulose Membranes Embedded with Gold–Silver Bimetallic Nanoparticles for the Efficient Reduction of 4-Nitrophenol DOI Creative Commons
Maria Deus Carvalho, João Henrique G. Lago, Samar Hajjar‐Garreau

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Bimetallic nanoparticles (BNPs) have attracted much attention recently due to their improved properties compared monometallic ones. Gold and silver (AuAgNPs) are among the most studied BNPs. Using these particles as powder or dispersion has drawbacks such ease of aggregation difficulty separating recovering from reaction medium. Therefore, immobilizing in polymeric matrices, cellulose, is appealing. In this context, present work focused on preparing unmodified cellulose membranes containing AuAgNPs for use heterogeneous catalysts reducing pollutant 4-nitrophenol. Incorporating into represents a significant advancement catalysis. addition being eco-friendly, offer handling potential reusability, which crucial factors The were prepared an aqueous medium seeded growth shell around AuNP seeds. Images recorded by transmission electron microscopy showed that diameters smaller than 100 nm core-shell type. membrane was dissolving microcrystalline ionic liquid, followed regeneration process using water. Next, bimetallic incorporated membrane. analyses revealed contain homogeneously distributed matrix, inductively coupled plasma-optical emission spectroscopy (ICP-OES) 0.339 wt % 0.069% gold. produced efficient 4-nitrophenol, used at least four cycles without loss efficiency. This material can be easily isolated medium, avoiding centrifugation filtration processes reuse. study first supported nonmodified catalysts, marking catalysis science.

Language: Английский

Citations

0
From waste to wellness: Green synthesis of nanoparticles from vegetable waste DOI Creative Commons

Muhammad Wasiq,

Faiyaz Ahmed, Farhan Saeed

et al.

Sustainable Environment, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 16, 2025

Language: Английский

Citations

0