A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health DOI Open Access
Claire J. Han, Xia Ning, Christin E. Burd

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1694 - 1694

Published: Dec. 19, 2024

Background: Gastrointestinal (GI) distress is prevalent and often persistent among cancer survivors, impacting their quality of life, nutrition, daily function, mortality. GI health screening crucial for preventing managing this distress. However, accurate classification methods remain unexplored. We aimed to develop machine learning (ML) models classify status (better vs. worse) by incorporating biological aging social determinants (SDOH) indicators in survivors. Methods: included 645 adult survivors from the 1999–2002 NHANES survey. Using training test datasets, we employed six ML conditions worse). These incorporated leukocyte telomere length (TL), SDOH, demographic/clinical data. Results: Among models, random forest (RF) performed best, achieving a high area under curve (AUC = 0.98) dataset. The gradient boosting (GBM) demonstrated excellent performance with AUC (0.80) TL, several socio-economic factors, risk behaviors (including lifestyle choices), inflammatory markers were associated health. most significant input features better our longer TL an annual household income above poverty level, followed routine physical activity, low white blood cell counts, food security. Conclusions: Our findings provide valuable insights into classifying identifying factors related health, including SDOH indicators. To enhance model predictability, further longitudinal studies external clinical validations are necessary.

Language: Английский

Frailty and neurocognitive impairments in Chinese survivors of childhood cancer DOI Creative Commons
Yihui Wei, Weishang Deng, Kenneth K.W. To

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

This study aimed to evaluate the prevalence and predictors of frailty association between neurocognitive impairments among Chinese survivors childhood cancer.

Language: Английский

Citations

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Rethinking the rise of early onset gastrointestinal cancers: a call to action DOI Creative Commons
Benjamin A. Weinberg, Caitlin C. Murphy, David R. Freyer

et al.

JNCI Cancer Spectrum, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 3, 2025

Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed patients under age 50 for reasons that remain poorly understood. The most significant change increase incidence rates of early-onset colorectal cancer, especially left-sided colon and rectal cancers. Increases gastric, pancreatic, other cancer diagnoses have further contributed to this trend. We formed multidisciplinary Think Tank develop strategic, coordinated approach studying This area research is challenging given multifactorial etiologies. focused on epidemiology environment, microbiome, survivorship as key pillars structure framework. advocate comprehensive strategy (1) use existing biospecimens, those collected longitudinally, with correlation exposures (the exposome); (2) standardize microbiome specimen collection analyses blood, tissue, stool specimens minimize contamination biases; (3) prioritize mechanistic studies evaluate findings from biomarker studies; (4) explore unique needs young population. These recommendations build upon prior efforts goal streamlining into important field study while minimizing redundant efforts. hope our serve clarion call motivate others discover why individuals are being at such an alarming rate how best support who diagnosed.

Language: Английский

Citations

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Calcium (Ca2+) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS) DOI Creative Commons

Andrea Puebla-Huerta,

Hernán Huerta,

Camila Quezada-Gutierez

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 21, 2025

Language: Английский

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The complex interplay between aging and cancer DOI
Lucrezia A. Trastus, Fabrizio d’Adda di Fagagna

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

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Joint association of frailty index and biological aging with all-cause and cause-specific mortality: a population-based longitudinal cohort study DOI Creative Commons
Shibing Zhou,

Guang Chen,

Tung-Leong Fong

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 105856 - 105856

Published: April 1, 2025

The role of frailty in all-cause, cardiovascular, and cancer mortality is debatable, the modification effect biological aging remains unclear. Therefore, we aimed to evaluate joint association index with all-cause cause-specific mortality. In this population-based cohort study, data were obtained from National Health Nutrition Examination Survey (NHANES) Death Index (NDI). Demographic variables extracted, was constructed, calculated. All-cause deaths, cardiovascular disease (CVD) deaths extracted as outcomes. Cox proportional hazards regression models used estimate correlations, stratified subgroup analyses figure out modifiers, sensitivity confirm robustness. A total 22,729 NHANES participants included 6786 1830 CVD 1396 occurred during an average follow-up 8.5 years over a 192,601 person-years. hazard ratios (HRs) delayed group for mortality, 0.45 (95 % CI: 0.41-0.49), 0.39 0.34-0.45), 0.54 0.46-0.63), respectively, compared accelerated (P all comparisons < 0.001). Likewise, score positively associated (HR, 1.06 [95 CI, 1.06-1.06] per 0.01 increase index), 1.07 1.06-1.07] 1.04 1.03-1.04] index). associations modified by interaction = 0.044), but not 0.482). Accelerated higher index, whereas inversely risk Biological among These findings suggest that people high acceleration aging, lower degree decrease approaches such lifestyle modifications might be beneficial individual's longevity lifespan.

Language: Английский

Citations

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The Use of Biomarkers in Precision Health Symptom Science—Opportunities and Challenges DOI Creative Commons
Carolyn Harris, Yvette P. Conley, Jinbing Bai

et al.

Seminars in Oncology Nursing, Journal Year: 2025, Volume and Issue: unknown, P. 151886 - 151886

Published: April 1, 2025

Language: Английский

Citations

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Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer DOI Creative Commons
Matia B. Solomon, Ravi Bhatia, Song Wang

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Gerotherapeutics: Aging Mechanism-based Pharmaceutical and Behavioral Interventions to Reduce Cancer Racial and Ethnic Disparities DOI
Jeanne S. Mandelblatt, Michael H. Antoni, Traci N. Bethea

et al.

JNCI Journal of the National Cancer Institute, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Abstract The central premise of this article is that a portion the established relationships between social determinants health and racial ethnic disparities in cancer morbidity mortality mediated through differences rates biological aging processes. We further posit using knowledge about could enable discovery testing new mechanism-based pharmaceutical behavioral interventions (“gerotherapeutics”) to differentially improve survivors from minority populations reduce disparities. These hypotheses are based on evidence lifelong adverse contribute (“social aging”), with individuals minoritized groups experiencing accelerated (ie, steeper slope or trajectory over time relative chronological age) more often than nonminoritized groups. Acceleration can increase risk, age onset, aggressiveness, stage many adult cancers. There also documented negative feedback loops whereby cellular damage caused by its therapies act as drivers additional aging. Together, these dynamic intersectional forces outcomes vs populations. highlight key targetable mechanisms potential applications reducing discuss methodological considerations for preclinical clinical impact gerotherapeutics Ultimately, promise will require broad societal policy changes address structural causes ensure equitable access all control paradigms.

Language: Английский

Citations

2
Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis DOI
Nikitchenko IuV, Vladimir Klochkov, Nataliya Kavok

et al.

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 25, 2024

Language: Английский

Citations

1
Frailty and Neurocognitive Impairments in Chinese Survivors of Childhood Cancer DOI Creative Commons
Yihui Wei, Weishang Deng, Kenneth K.W. To

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Purpose This study aimed to evaluate the prevalence and predictors of frailty association between neurocognitive impairments among Chinese survivors childhood cancer. Methods A total 185 cancer were recruited from a long-term follow-up clinic in Hong Kong (response rate: 94.4%; 48.1% female; mean age 28.9 years, standard deviation = 6.7 years). Frailty was assessed using Fried criteria. Neurocognitive outcomes evaluated performance-based test. Multivariable logistic regression used identify frailty. generalized linear models explore associations cognitive outcomes. Results The proportions with pre-frailty 22.7% 27.0%, respectively. “Frail” more likely be diagnosed at younger (odds ratio [OR] 0.93, 95% confidence interval [CI]: 0.87–0.99, P 0.041) have coexisting chronic health conditions (OR 4.63, CI: 1.68–12.80, 0.003) than “non-frail” “pre-frail” survivors. Survivors exhibited worse attention detectability (unstandardized point estimate [Est] 4.57, error [SE] 1.69, 0.007), omissions (Est 3.68, SE 1.15, 0.001), flexibility 8.08, 3.08, 0.009) Conclusions More one fifth participating identified as phenotypically frail. associated performance executive function. Implications for Cancer Survivors: findings highlight needs regular monitoring early interventions that can modify aging pathway continuum, mitigate improve psychosocial during survivorship.

Language: Английский

Citations

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