Cited by O6-methylguanine-DNA methyltransferase inhibition leads to cellular senescence and vascular smooth muscle dysfunction

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities DOI

Qiuming Pan,

Zhu Ye,

Zhi Ting Ye

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Cellular senescence is characterized by a sustained and irreversible cessation of cell proliferation in response to diverse environmental stimuli. However, senescent cells exhibit strong metabolic activity release range cytokines inflammatory mediators into the tumor microenvironment, collectively referred as senescence‐associated secretory phenotype (SASP). In recent years, develop new therapies for cancers, researchers have conducted extensive studies on mechanism cancer revealed that induction could effectively suppress progression. it has been documented cellular not only inhibits initiation but also contributes significantly progression some cases. Hence, imperative comprehend correlation between tumorigenesis, discuss potential utilization mechanisms progression, which lays theoretical foundation drugs treat cancers. this review, we first provide an overview discovery its key milestone events. Meanwhile, review examines major stimulus senescence, provides categorization senescence. Subsequently, examination primary regulatory discussed, followed summary control SASP expression dual biological roles Additionally, common biomarkers utilized identification Finally, investigates efficacy “One‐Two punch” sequential treatment approach emerging challenges novel approach.

Language: Английский

Citations

H2AJ Is a Direct Androgen Receptor Target Gene That Regulates Androgen-Induced Cellular Senescence and Inhibits Mesenchymal Markers in Prostate Cancer Cells DOI

Mehdi Heidari Horestani,

Golnaz Atri Roozbahani,

Aria Baniahmad

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 791 - 791

Published: Feb. 25, 2025

Background: Prostate cancer (PCa) is a significant public health issue, particularly in developed countries. The androgen receptor (AR) plays key role regulating both the normal development and proliferation of PCa. Bipolar therapy, which involves treatment with supraphysiological levels (SALs), has been shown to inhibit PCa growth. SAL induces cellular senescence AR-positive cell lines, human tumor samples, xenografted mouse models. Methods: Transcriptome chromatin immunoprecipitation (ChIP)-seq analysis, ChIP-qPCR, knockdown (KD), overexpression (OE), qRT-PCR, immunodetection, situ histochemistry. Results: Here, we show using ChIP-seq RNA-seq that H2AJ, variant canonical histone H2A, direct target gene AR regulates formation senescence-associated heterochromatin foci (SAHF). Accordingly, bioinformatic analyses reveal large overlap H2AJ transcriptome score Analyzing cohort patient expression higher samples compared suggesting growth-promoting activity. Interestingly, however, diminished metastatic indicating inhibits mesenchymal transition cells. Functionally, KD growth, whereas promotes Furthermore, these data suggest markers, agreement low forms tumors from cohorts. Conclusion:H2AJ positively AR-regulated induced by SALs senescence, markers.

Language: Английский

Citations

CKS1B regulates the radiosensitivity of lung cancer via activating the PI3K/AKT signaling pathway DOI

Jiangyue Lu,

Lehui Du,

Pei Zhang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111828 - 111828

Published: April 1, 2025

Language: Английский

Citations

O6-methylguanine-DNA methyltransferase inhibition leads to cellular senescence and vascular smooth muscle dysfunction DOI

Jakub Krivy,

Svetozár Mišúth,

Marina Puchovska

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118103 - 118103

Published: April 28, 2025

Language: Английский

Citations