Gut microbiota and rheumatic diseases: new insights into pathogenesis DOI Creative Commons
Aldona Pażyra, Katarzyna Nowakowska, Piotr Więsyk

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 18, P. 53972 - 53972

Published: Aug. 12, 2024

Background: Rheumatic diseases are a group of disorders characterised by loss immune tolerance, which leads to chronic inflammation, degeneration or metabolic abnormalities in various organs tissues. Despite the lack clarity surrounding causes these diseases, both environmental and genetic factors play an important role. Recent research indicates that alterations composition gut microbiota, known as dysbiosis, may contribute development number rheumatic including rheumatoid arthritis, systemic lupus, ankylosing spondylitis, scleroderma Sjögren's syndrome. The microbiota influences balance between pro- anti-inflammatory responses, have implications for pathogenesis diseases. Furthermore, studies indicated be associated with response therapies used treat thus opening up new avenues microbiota-targeted treatments conditions. Aim study: objective this review is investigate impact on evaluate potential targeting manipulation microbiota. Material methods: present study based literature available scientific databases from 2019-2024, such PubMed, Corchane Library Google Scholar.Results conclusions: A growing body evidence suggests link Patients often exhibit reduced ratio Firmicutes Bacteroidetes abnormal numbers Bacteroides. Molecular mimicry association short-chain fatty acids also been observed. Further human needed more fully understand role therapeutic interventions.

Language: Английский

The tongue microbiome: A gateway to systemic health and disease DOI
Marwan Mansoor Ali Mohammed, Sausan Al Kawas, Gamilah Al-Qadhi

et al.

Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Indoxyl sulfate (IS) mediates pro-inflammatory responses in severe pneumonia in patients with rheumatoid arthritis associated interstitial lung disease DOI
Minghua Zhan, Ziyao Li, Jianing Chen

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110430 - 110430

Published: Jan. 1, 2025

Language: Английский

Citations

0
Gut microbiota and risk of iron deficiency anemia: A two-sample Mendelian randomization study DOI Creative Commons

Wenhui Lei,

Zhaoyun Liu,

Hai-Ping Lai

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(8), P. e41617 - e41617

Published: Feb. 21, 2025

Previous studies have suggested a link between gut microbiota and iron-deficiency anemia (IDA). However, interpreting these findings is difficult due to various factors that influence microbiome composition the limitations of observational studies, such as confounding variables reverse causation. This study aims explore causal relationship IDA using Mendelian randomization (MR) overcome limitations. We conducted 2-sample MR analysis data from genome-wide association MiBioGen Consortium UK Biobank. The included 211 genus-level microbes linked single-nucleotide polymorphisms 18,340 participants in Consortium. outcome for were obtained 484,598 Biobank, with 2941 cases 481,657 controls. assessed relationships techniques, primarily inverse variance weighting, performed sensitivity analyses confirm robustness our results. Nine significantly associated ( P < .05). Protective Clostridia, Actinomycetaceae, Pasteurellaceae, Oscillospira, Prevotella, Roseburia, while risk Ruminococcus gnavus group, Hungatella, Parasutterella. Sensitivity showed reliability without significant variability. provides evidence specific bacteria risk, identifying potential targets therapies aimed at improving outcomes those IDA. Further research needed clarify involved.

Language: Английский

Citations

0
Gut microbiota and rheumatic diseases: new insights into pathogenesis DOI Creative Commons
Aldona Pażyra, Katarzyna Nowakowska, Piotr Więsyk

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 18, P. 53972 - 53972

Published: Aug. 12, 2024

Background: Rheumatic diseases are a group of disorders characterised by loss immune tolerance, which leads to chronic inflammation, degeneration or metabolic abnormalities in various organs tissues. Despite the lack clarity surrounding causes these diseases, both environmental and genetic factors play an important role. Recent research indicates that alterations composition gut microbiota, known as dysbiosis, may contribute development number rheumatic including rheumatoid arthritis, systemic lupus, ankylosing spondylitis, scleroderma Sjögren's syndrome. The microbiota influences balance between pro- anti-inflammatory responses, have implications for pathogenesis diseases. Furthermore, studies indicated be associated with response therapies used treat thus opening up new avenues microbiota-targeted treatments conditions. Aim study: objective this review is investigate impact on evaluate potential targeting manipulation microbiota. Material methods: present study based literature available scientific databases from 2019-2024, such PubMed, Corchane Library Google Scholar.Results conclusions: A growing body evidence suggests link Patients often exhibit reduced ratio Firmicutes Bacteroidetes abnormal numbers Bacteroides. Molecular mimicry association short-chain fatty acids also been observed. Further human needed more fully understand role therapeutic interventions.

Language: Английский

Citations

0