Deutsche Zeitschrift für Akupunktur, Journal Year: 2024, Volume and Issue: 67(4), P. 230 - 232
Published: Oct. 24, 2024
Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 132 - 132
Published: Jan. 20, 2025
Resveratrol, a bioactive phytoalexin, has been extensively studied as pharmaceutical and nutraceutical candidate for the treatment of various diseases. Although its therapeutic effects have largely attributed to anti-oxidant properties, underlying mechanisms dose dependency are not well understood. Recent studies shown that cell-free chromatin particles (cfChPs), which released daily from billions dying cells, can enter circulation be internalized by healthy wherein they trigger damaging effects, including double-strand DNA breaks. Notably, deactivating cfChPs using mixture resveratrol copper neutralize their harmful effects. The addition imparts novel property viz. generation reactive oxygen species (ROS), capable without genomic DNA. This perspective article discusses how deactivation via ROS generated combining with multiple Exploiting deactivate ameliorate disease conditions may viable approach.
Language: Английский
Citations
0
Journal of Reproductive Healthcare and Medicine, Journal Year: 2025, Volume and Issue: 6, P. 5 - 5
Published: Feb. 28, 2025
Antioxidants are essential for fertility and reproductive health. Cellular oxidative nitrosative stress induced by free radicals might negatively impact organ function. Numerous complications disorders, such as endometriosis, polycystic ovarian syndrome, oocyte aging, dysmenorrhea premenstrual spontaneous abortion, infertility, have been linked to imbalances in the oxidant/ antioxidant interaction. Studies examined dietary supplementation that has focus of treatment and/or prevention recurring abortions infertility cannot be explained. The sources exploited which can abolish reactive oxygen species from our system management diseases promoting normal physiology. This review focuses on therapies disease stress, well function antioxidants play female health fertility.
Language: Английский
Citations
0
Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1571 - 1571
Published: Sept. 19, 2024
Circular RNAs (circRNAs) are a class of circular non-coding that play essential roles in the intricate and dynamic networks governing cell growth, development, apoptosis. Resveratrol (RSV), non-flavonoid polyphenol, is known to participate follicular development ovulation. In our previous research, we established model using porcine ovarian granulosa cells (POGCs) treated with resveratrol, which confirmed its regulatory effects on long (lncRNAs) microRNAs (miRNAs) within these cells. However, influence resveratrol circRNA expression has not been thoroughly investigated. To explore how affects levels POGCs, designed an experiment three groups: control group (CON, n = 3, 0 μM RSV), low-dose RSV (LOW, 50 high-dose (HIGH, 100 RSV) for sequencing. We identified total 10,045 candidate circRNAs from POGCs different concentrations (0, 50, μM). Differential analysis indicated 96 were significantly altered LOW vs. CON group, while 109 showed significant changes HIGH group. These notably enriched biological processes associated metabolism, apoptosis, oxidative stress. Functional enrichment host genes revealed their involvement critical signaling pathways, including mTOR, AMPK, apoptosis pathways. Additionally, potential miRNA sponge candidates among differentially expressed circRNAs, particularly novel_circ_0012954 novel_circ_0004762, exhibited strong connectivity miRNA-target networks. Our findings provide valuable insights into mechanisms context resveratrol-induced highlighting as innovative therapeutic targets reproductive biology.
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4258 - 4258
Published: Dec. 10, 2024
Resveratrol and extra virgin olive oil are both recognized for their potential protective effects against age-related diseases. This overview highlights mechanisms of action, health benefits, the scientific evidence supporting roles in promoting longevity cognitive health. A literature search was conducted. Important findings related to clinical implications resveratrol EVOO were summarized. Both have complementary that may enhance anti-aging effects. promising disease-protective agents. Their antioxidant, anti-inflammatory, neuroprotective properties contribute improved outcomes longevity. Incorporating these compounds into a balanced diet offer significant benefits aging populations, reducing risk chronic Continued research is essential fully understand optimize use settings. Future should focus on investigating synergistic when consumed together, as they each other’s bioavailability efficacy health; conducting extensive trials confirm long-term various particularly individuals; further exploring molecular pathways through which exert effects, including interactions with gut microbiota metabolic pathways.
Language: Английский
Citations
1
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25
Published: Dec. 16, 2024
The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.
Language: Английский
Citations
1
Deutsche Zeitschrift für Akupunktur, Journal Year: 2024, Volume and Issue: 67(4), P. 230 - 232
Published: Oct. 24, 2024
Citations
0