Modulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage DOI Creative Commons

Jing Xu,

Yundie Liu,

Xuanhong Cao

et al.

Stress Biology, Journal Year: 2024, Volume and Issue: 4(1)

Published: Sept. 30, 2024

Abstract Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aimed to explore the preventive effect of AH on liver damage induced by heat stress (HS) its underlying mechanism. HS models were established thermostat, mice treated at 39 ℃ for 10 h, lasting 7 days. Hematoxylin–eosin (H&E) staining Periodic Acid-Schiff (PAS) used histological observation, transmission electron microscopy (TEM) was ultrastructure examination hepatocytes. Gut microbiota (GM) composition metabolites respectively analyzed 16S rRNA sequencing non-targeted metabolome sequencing. pretreatment alleviated caused in mice. The main manifestation that serum aspartate transferase (AST) transaminase (ALT). It found improved symptoms hepatocyte damage. In addition, relative abundance f_ Rikenellaceae , g_ Incertae_Sedis s_ Staphylococcus_Orisratti Lachnoclostridium GCA-900066575, Alistipes_inops modified these bacterial genera showed association 6 (2- (3,4-dihydroxyphenyl) acetamide, 3-hydroxy-3-methylpentanedioic acid, PC (17:0/17:1), Y-L-Glutamy-L-glutamic L-Isoleucine, 5-Methyluridine, 8,8-dimethyl-2-phenyl-4H,8H-pyrano [2, 3-h] chromen-4-one). Pearson analysis also strong correlation between microbes 2 risk indicators (AST ALT) HS-induced regulating metabolism maintaining normal GM. demonstrated held potential as prophylactic drug prevention

Language: Английский

Natural small molecules synergize mesenchymal stem cells for injury repair in vital organs: a comprehensive review DOI Creative Commons
Y. H. Qu, Zhe Wang,

Lingjuan Dong

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 7, 2024

Abstract Mesenchymal stem cells (MSCs) therapy is a highly researched treatment that has the potential to promote immunomodulation and anti-inflammatory, anti-apoptotic, antimicrobial activities. It thought it can enhance internal organ function, reverse tissue remodeling, achieve significant repair regeneration. However, limited infusion, survival, engraftment of transplanted MSCs diminish effectiveness MSCs-based therapy. Consequently, various preconditioning methods have emerged as strategies for enhancing therapeutic effects achieving better clinical outcomes. In particular, use natural small molecule compounds (NSMs) pretreatment strategy discussed in this narrative review, with focus on their roles regulating injury vital organs. Additionally, discussion focuses future directions challenges transforming mesenchymal cell research into applications.

Language: Английский

Citations

4
Modulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage DOI Creative Commons

Jing Xu,

Yundie Liu,

Xuanhong Cao

et al.

Stress Biology, Journal Year: 2024, Volume and Issue: 4(1)

Published: Sept. 30, 2024

Abstract Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aimed to explore the preventive effect of AH on liver damage induced by heat stress (HS) its underlying mechanism. HS models were established thermostat, mice treated at 39 ℃ for 10 h, lasting 7 days. Hematoxylin–eosin (H&E) staining Periodic Acid-Schiff (PAS) used histological observation, transmission electron microscopy (TEM) was ultrastructure examination hepatocytes. Gut microbiota (GM) composition metabolites respectively analyzed 16S rRNA sequencing non-targeted metabolome sequencing. pretreatment alleviated caused in mice. The main manifestation that serum aspartate transferase (AST) transaminase (ALT). It found improved symptoms hepatocyte damage. In addition, relative abundance f_ Rikenellaceae , g_ Incertae_Sedis s_ Staphylococcus_Orisratti Lachnoclostridium GCA-900066575, Alistipes_inops modified these bacterial genera showed association 6 (2- (3,4-dihydroxyphenyl) acetamide, 3-hydroxy-3-methylpentanedioic acid, PC (17:0/17:1), Y-L-Glutamy-L-glutamic L-Isoleucine, 5-Methyluridine, 8,8-dimethyl-2-phenyl-4H,8H-pyrano [2, 3-h] chromen-4-one). Pearson analysis also strong correlation between microbes 2 risk indicators (AST ALT) HS-induced regulating metabolism maintaining normal GM. demonstrated held potential as prophylactic drug prevention

Language: Английский

Citations

0