A meta-analysis of age-dependent changes in extracellular vesicle proteins in C. elegans DOI Creative Commons
Prasun Kumar Bhunia, Prasad Kasturi

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Extracellular vesicles (EVs) contribute to the maintenance of organism-wide proteostasis by mediating intercellular communication. Loss and altered communication are associated with aging age-related diseases, suggesting key roles for EVs. However, it is unclear how proteome EVs changes age. To identify EV-associated proteins (EVAPs) their fate age, we curated publicly available data from C. elegans model organism. Our analysis reveals that carry involve protein quality control. We found abundance EV significantly Many these also aggregate age overlap Aβ driven aggregates. observe a subset alter in response heat stress pathogen infections Further, human orthologs EVAPs brain tissues affected Alzheimer’s disease. This meta-analysis highlights composition, changes, aggregation during aging, disease conditions. Overall, this study provides new insights into dynamics may possibly help identifying potential biomarkers diseases.

Language: Английский

Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization DOI Creative Commons
Guei‐Sheung Liu, Huai‐An Chen,

Che-Yi Chang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123205 - 123205

Published: Feb. 24, 2025

Language: Английский

Citations

0
Comment on “Extracellular Vesicles Slow Down Aβ(1–42) Aggregation by Interfering with the Amyloid Fibril Elongation Step” DOI Creative Commons
Mohsin Shafiq, Andreu Matamoros‐Angles,

Sussane Caroline Meister

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(21), P. 3791 - 3793

Published: Oct. 9, 2024

Halipi et al. explored the impact of extracellular vesicles (EVs) on amyloid-β (Aβ) aggregation. They concluded that EVs reduce Aβ aggregation, as seen by shorter and thicker fibrils. While we agree with complex role in Alzheimer's disease, are sceptical claim slow down noting missing key references. Previous literature rather suggests (derived from neuronal cell lines) accelerate process fibrillation plaque formation. al.'s findings may be skewed due to lack essential neuronally expressed Aβ-binding partners, like prion protein (PrPC) their EV samples. The commentary, light included original experiments cited literature, membrane proteins PrPC crucial fully understand conclusions should reexamined these factors.

Language: Английский

Citations

0
A meta-analysis of age-dependent changes in extracellular vesicle proteins in C. elegans DOI Creative Commons
Prasun Kumar Bhunia, Prasad Kasturi

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Extracellular vesicles (EVs) contribute to the maintenance of organism-wide proteostasis by mediating intercellular communication. Loss and altered communication are associated with aging age-related diseases, suggesting key roles for EVs. However, it is unclear how proteome EVs changes age. To identify EV-associated proteins (EVAPs) their fate age, we curated publicly available data from C. elegans model organism. Our analysis reveals that carry involve protein quality control. We found abundance EV significantly Many these also aggregate age overlap Aβ driven aggregates. observe a subset alter in response heat stress pathogen infections Further, human orthologs EVAPs brain tissues affected Alzheimer’s disease. This meta-analysis highlights composition, changes, aggregation during aging, disease conditions. Overall, this study provides new insights into dynamics may possibly help identifying potential biomarkers diseases.

Language: Английский

Citations

0