Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis

Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 100972 - 100972

Published: Jan. 1, 2025

Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on after injury through regulation antioxidant capacity mitochondrial biogenesis. treatment significantly increased ratio tibialis anterior mass body weight, alongside reduced fasting glucose levels. Following cardiotoxin-induced injury, improved regeneration, characterized by greater formation new fibers better structural repair compared control. Notably, gene expression analyses demonstrated that RES-treated mice exhibited elevated levels myogenic markers, such as paired box 7 (Pax7), factor 5 (Myf5), myoblast determination protein (MyoD), Myogenin (MyoG). Concurrently, yes-associated (YAP) increased, underscoring its role regulating satellite cell activity. Transcriptomic analysis identified enriched pathways related biogenesis, with transcription factors higher DNA content mice. Furthermore, enhanced via Kelch-like ECH-associated 1 (KEAP-1)/nuclear erythroid 2-related 2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway, indicated activities total capacity, Glutathione peroxidase (GSH-PX), superoxidase dismutase (SOD). Collectively, these findings suggest not only promotes but also supports function defenses, positioning it food-derived pharmaceutical for targeting injury.

Language: Английский

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Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9118 - 9118

Published: Aug. 22, 2024

The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.

Language: Английский

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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or functional defect itself. Clinically, diabetes is classified into type 1 (T1DM) and 2 (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, global incidence has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway crucial regulating cellular energy metabolism, marking it as significant therapeutic target for related complications. Natural products, their diverse origins, multifaceted bioactivities, relative safety, hold considerable promise modulating AMPK pathway. review article explores advances research on natural products that pathway, aiming to inform development innovative antidiabetic therapies.

Language: Английский

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Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5245 - 5245

Published: Nov. 6, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic disease. The development of MASLD is influenced by multitude diseases associated with modern lifestyles, including but not limited to diabetes mellitus, hypertension, hyperlipidaemia and obesity. These conditions are often consequences the adoption unhealthy habits, namely sedentary lifestyle, lack physical activity, poor dietary choices excessive alcohol consumption. treatment primarily based on modifying patient's lifestyle pharmacological intervention. Despite absence FDA-approved agents for MASLD, several potential therapeutic modalities have demonstrated efficacy in reversing histopathological features Among botanical ingredients belonging flavonoid group quercetin (QE). QE has been possess number beneficial physiological effects, anti-inflammatory, anticancer antifungal properties. Additionally, it functions as natural antioxidant. Preclinical evidence indicates that may play role reducing damage improving metabolic health. Early human studies also suggest be an effective due its antioxidant, lipid-regulating This review aims summarize available information effects MASLD.

Language: Английский

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Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Processes, Journal Year: 2024, Volume and Issue: 12(6), P. 1216 - 1216

Published: June 13, 2024

Resveratrol is a natural compound that can be found in red wine, grapes, and berries. It has attracted attention due to its potential health benefits. The aim of this review was align ways retaining resveratrol contents berries products made berries, show which agricultural processing techniques maximize the content their how achieved. scientific literature revealed concentration berry-derived varies significantly depending on source applied. range from 0.03–0.06 mg/kg blueberries 5–10 grape skins. Agricultural such as controlled water stress (e.g., increasing grapes 8.3–11.5 mg/kg), optimal sun exposure enhancing 1.5–2.1 balanced nutrient management, selecting high-resveratrol cultivars up 15 certain grapes) substantially increase content. Processing methods like cold pressing, centrifugation, ultrafiltration, freeze-drying are effective preserving levels, while traditional pasteurization tends reduce concentration. For instance, high-temperature short-time juice 1.5 0.8 mg/kg, whereas pressing retains more (1.5 1.4 mg/kg). By optimizing these techniques, manufacturers enhance products, meeting growing consumer demand for health-enhancing supporting healthier society. This approach aligns with commitment overcoming technical challenges associated use, ensuring fully realized both health-related non-health-related applications.

Language: Английский

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Green Tea Polyphenol (-)-Epicatechin Pretreatment Mitigates Hepatic Steatosis in an In Vitro MASLD Model

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8981 - 8994

Published: Aug. 16, 2024

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is becoming more prominent globally due to an increase in the prevalence of obesity, dyslipidemia, and type 2 diabetes. A great deal studies have proposed potential treatments for MASLD, with few them demonstrating promising results. The aim this study was investigate effects (-)-epicatechin (EPI) on development MASLD vitro model using HepG2 cell line by determining metabolic viability cells levels PPARα, PPARγ, GSH. were pretreated 10, 30, 50, 100 μM EPI 4 h assess lipid metabolism. culture established hepatocytes which exposed 1.5 mM oleic acid (OA) 24 h. Moreover, colorimetric MTS assay used order determine cells, PPARα PPARγ protein determined enzyme-linked immunosorbent (ELISA), accumulation visualized Oil Red O Staining method. Also, intracellular glutathione (GSH) measured level oxidative stress. shown treated OA. after incubation OA, significantly decreased, a 71%, compared EPI, where 74–86% respect concentration experiment. Furthermore, GSH exhibited decrease response increasing concentrations. Pretreatment has demonstrated effect vitro. Therefore, considering that mediates metabolism it should be considered hepatoprotective agent future research.

Language: Английский

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The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

According to statistics, more than one‐third of the global population currently experiences sleep problems, and about 10% adults have been diagnosed with insomnia, a proportion that is increasing annually. Most used insomnia medications are not specifically developed but discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there an urgent need find safer effective therapeutic options. Resveratrol, natural polyphenolic compound, shows significant potential improving insomnia. Research its may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti‐inflammation, circadian rhythm regulation, modulation neurotransmitters (gamma‐aminobutyric acid (GABA), DA, 5‐HT, cortisol), increased levels neurotrophic factor BDNF. Additionally, resveratrol’s treatment closely linked SIRT1, AMPK, NF‐ κ B, mTOR, PI3K/Akt, MAPK pathways. This review summarizes mechanisms resveratrol treating provide researchers deeper understanding action, which can aid development novel targeted drugs offer innovative ideas methods for clinical treatment.

Language: Английский

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Combining nutraceuticals and a mediterranean diet for managing metabolic dysfunction associated with steatotic liver disease

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 25, 2025

This study was performed by Cano Contreras et al, who explored the effects of alpha-lipoic acid (ALA) and Silybum marianum (SM) supplementation combined with a mediterranean diet (MD) on metabolic dysfunction-associated steatotic liver disease (MASLD). The randomized controlled design use transient elastography provide methodological strengths, whereas focus Mexican cohort addresses critical gap in regional MASLD research. Although improvements visceral fat attenuation parameters (CAP) were observed, key markers, including transaminases lipid profiles, showed no significant changes, raising concerns about intervention's comprehensive impact. reliance CAP absence mechanistic biomarker analysis limit insights into antioxidant anti-inflammatory pathways ALA SM. Future research should explore synergistic other nutraceuticals, such as vitamin E polyphenols, include extended follow-up patient stratification to assess long-term benefits personalized therapeutic outcomes. Addressing these limitations could solidify role nutraceuticals management enable development more effective sustainable interventions.

Language: Английский

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Effects of Lifestyle Interventions on Metabolic Dysfunction-Associated Steatotic Liver Disease

Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 199 - 215

Published: Jan. 1, 2025

Language: Английский

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