Atrial fibrillation is not associated with altered left atrial microRNA expression profile in advanced heart failure patients
Heart Rhythm,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Atrial
fibrillation
(AF)
is
common
in
patients
with
chronic
heart
failure
(HF).
Nevertheless,
some
HF
remain
sinus
rhythm
(SR)
even
marked
left
atrial
(LA)
dilatation
and
fibrosis.
The
underlying
mechanisms
for
the
differences
arrhythmogenicity
are
poorly
uncovered.
Recent
findings
indicate
that
distinct
microRNAs
(miRNA)
might
induce
LA
structural
molecular
alterations.
However,
impact
of
miRNA
dysregulation
on
AF
development
context
has
not
been
studied
independently
remodeling.
This
study
aimed
to
evaluate
expressions
or
SR.
myocardial
samples
were
obtained
from
advanced
(n=12;
paroxysmal
n=4,
as
persistent/permanent
n=8)
SR
(n=12)
undergoing
transplantation.
extent
interstitial
fibrosis
was
evaluated
using
picrosirius
red-staining.
load
estimated
by
measuring
mRNA
expression
NPPA
gene
encoding
natriuretic
peptide
qRT-PCR
circulating
N-terminal
proatrial
(NT-proANP)
ELISA.
screening
performed
NanoString
technology.
dilatation,
fibrosis,
expression,
well
NT-proANP
levels
similar
between
groups,
suggesting
a
comparable
remodeling
among
groups.
analysis
revealed
no
after
subgroup
analysis.
profile
shows
distinction
pathological
Language: Английский
Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases
Chuan Xu,
No information about this author
Chaoyang Jiang,
No information about this author
Zhihui Li
No information about this author
et al.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 15, 2024
Exosomes
are
nanoscale
vesicles
of
cellular
origin.
One
the
main
characteristics
exosomes
is
their
ability
to
carry
a
wide
range
biomolecules
from
parental
cells,
which
important
mediators
intercellular
communication
and
play
an
role
in
physiological
pathological
processes.
have
advantages
biocompatibility,
low
immunogenicity,
biodistribution.
As
researchers'
understanding
has
increased,
various
strategies
been
proposed
for
use
diagnosing
treating
diseases.
Here,
we
provide
overview
biogenesis
composition
exosomes,
describe
relationship
between
disease
progression,
focus
on
as
biomarkers
early
screening,
monitoring,
guiding
therapy
refractory
diseases
such
tumors
neurodegenerative
We
also
summarize
current
applications
especially
engineered
efficient
drug
delivery,
targeted
therapies,
gene
immune
vaccines.
Finally,
challenges
potential
research
directions
clinical
application
discussed.
In
conclusion,
emerging
molecule
that
can
be
used
diagnosis
treatment
diseases,
combined
with
multidisciplinary
innovative
solutions,
will
applications.
Language: Английский