Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases DOI Creative Commons

Chuan Xu,

Chaoyang Jiang, Zhihui Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Exosomes are nanoscale vesicles of cellular origin. One the main characteristics exosomes is their ability to carry a wide range biomolecules from parental cells, which important mediators intercellular communication and play an role in physiological pathological processes. have advantages biocompatibility, low immunogenicity, biodistribution. As researchers' understanding has increased, various strategies been proposed for use diagnosing treating diseases. Here, we provide overview biogenesis composition exosomes, describe relationship between disease progression, focus on as biomarkers early screening, monitoring, guiding therapy refractory diseases such tumors neurodegenerative We also summarize current applications especially engineered efficient drug delivery, targeted therapies, gene immune vaccines. Finally, challenges potential research directions clinical application discussed. In conclusion, emerging molecule that can be used diagnosis treatment diseases, combined with multidisciplinary innovative solutions, will applications.

Language: Английский

Atrial fibrillation is not associated with altered left atrial microRNA expression profile in advanced heart failure patients DOI Creative Commons
T Bálint, Mihály Ruppert, Bence Ágg

et al.

Heart Rhythm, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Atrial fibrillation (AF) is common in patients with chronic heart failure (HF). Nevertheless, some HF remain sinus rhythm (SR) even marked left atrial (LA) dilatation and fibrosis. The underlying mechanisms for the differences arrhythmogenicity are poorly uncovered. Recent findings indicate that distinct microRNAs (miRNA) might induce LA structural molecular alterations. However, impact of miRNA dysregulation on AF development context has not been studied independently remodeling. This study aimed to evaluate expressions or SR. myocardial samples were obtained from advanced (n=12; paroxysmal n=4, as persistent/permanent n=8) SR (n=12) undergoing transplantation. extent interstitial fibrosis was evaluated using picrosirius red-staining. load estimated by measuring mRNA expression NPPA gene encoding natriuretic peptide qRT-PCR circulating N-terminal proatrial (NT-proANP) ELISA. screening performed NanoString technology. dilatation, fibrosis, expression, well NT-proANP levels similar between groups, suggesting a comparable remodeling among groups. analysis revealed no after subgroup analysis. profile shows distinction pathological

Language: Английский

Citations

0
Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases DOI Creative Commons

Chuan Xu,

Chaoyang Jiang, Zhihui Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Exosomes are nanoscale vesicles of cellular origin. One the main characteristics exosomes is their ability to carry a wide range biomolecules from parental cells, which important mediators intercellular communication and play an role in physiological pathological processes. have advantages biocompatibility, low immunogenicity, biodistribution. As researchers' understanding has increased, various strategies been proposed for use diagnosing treating diseases. Here, we provide overview biogenesis composition exosomes, describe relationship between disease progression, focus on as biomarkers early screening, monitoring, guiding therapy refractory diseases such tumors neurodegenerative We also summarize current applications especially engineered efficient drug delivery, targeted therapies, gene immune vaccines. Finally, challenges potential research directions clinical application discussed. In conclusion, emerging molecule that can be used diagnosis treatment diseases, combined with multidisciplinary innovative solutions, will applications.

Language: Английский

Citations

2