Intranasal administration of GRP78 protein (HSPA5) counteracts the neurodegeneration in the locus coeruleus in a model of chronic sleep restriction in rats DOI
М. Б. Пази, И. В. Екимова

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(8), P. 1238 - 1252

Published: Oct. 19, 2024

Chronic sleep restriction (sleep less than 6 hours per day) due to the workload and a decrease in quality is an endemic disease modern society. deprivation causes serious neuropsychiatric disorders associated with irreversible neurodegenerative changes brain. The search for pharmacological agents that can reduce risk of neurodegeneration as result chronic loss urgent task issue biomedicine. Intranasal administration glucose-regulated 78 kDa heat shock protein (GRP78) has neuroprotective effect rat model Parkinson´s disease. potential intranasally administered GRP78 not been previously studied. aim study find out whether preventive intranasal able weaken and/or stop process locus coeruleus (SR) rats. was conducted on months old male Wistar For deprivation, validated method swinging platform used mode: 3 1 hour rest continuously 5 days. Recombinant human two days before start SR during SR. Cellular molecular were studied using immunohistochemistry Western blotting. It shown leads degeneration 30% noradrenergic neurons coeruleus, increase levels activated caspases-3 9. This indicates development apoptosis along mitochondrial pathway. No signs reactive microgliosis found We have demonstrated penetrates accumulates counteracts death path apoptosis. data obtained allows consider agent prevention pathological consequences deprivation.

Language: Английский

Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis DOI Creative Commons
Meng Xu, Wanzhen Li,

Ruihong Xu

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103537 - 103537

Published: Feb. 8, 2025

Reactive oxygen species (ROS) play a pivotal role in maintaining tissue homeostasis, yet their overabundance can impair normal cellular functions, induce cell death, and potentially lead to neurodegenerative disorders. This study identifies Drosophila Glycoprotein 93 (Gp93) as crucial factor that safeguards homeostasis preserves neuronal functions by preventing ROS-induced, JNK-dependent apoptotic death. Firstly, loss of Gp93 induces apoptosis primarily through the induction ROS. Secondary, neuro-specific depletion results ROS-JNK-mediated neurodegeneration. Thirdly, overexpression effectively curtails oxidative stress neurodegeneration caused paraquat exposure or aging process. Furthermore, these be substituted its human ortholog, HSP90B1. Lastly, HSP90B1 cultured cells triggers ROS production, JNK activation, apoptosis. Thus, this not only unveils novel physiological function Gp93, but also provides valuable insights for understanding pathological

Language: Английский

Citations

0
Neurodegenerative Disease: From Molecular Basis to Therapy, 2nd Edition DOI Open Access
Claudia Ricci

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1929 - 1929

Published: Feb. 24, 2025

Neurodegenerative diseases, characterised by the progressive degeneration of neurons, are a heterogeneous group largely age-related disorders that affect millions people worldwide [...].

Language: Английский

Citations

0
Interplay of α-Synuclein Oligomers and Endoplasmic Reticulum Stress in Parkinson'S Disease: Insights into Cellular Dysfunctions DOI
Hui Zeng,

Ye Liu,

Xinjie Liu

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Language: Английский

Citations

3
Ferrous sulfate and lipopolysaccharide co-exposure induce neuroinflammation, neurobehavioral motor deficits, neurodegenerative and histopathological biomarkers relevant to Parkinson’s disease-like symptoms in Wistar rats DOI
Shivam Kumar Pandey,

Anjuman Nanda,

Avtar Singh Gautam

et al.

BioMetals, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

Citations

0
Exploring heat shock proteins as therapeutic targets for Parkinson’s disease DOI Creative Commons
Xiang Li, Wenjun Wang,

Pan Shi

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116633 - 116633

Published: Nov. 1, 2024

Language: Английский

Citations

2
Gene Therapy for Parkinson’s Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance DOI Open Access
Jintae Kim, Mi‐Yoon Chang

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12369 - 12369

Published: Nov. 18, 2024

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It characterized by progressive loss of dopaminergic (DAnergic) neurons in substantia nigra and decreased dopamine (DA) levels, which lead to both motor non-motor symptoms. Conventional PD treatments aim alleviate symptoms, but do not delay progression. gene therapy offers a promising approach improving current treatments, with potential significant symptoms cause fewer adverse effects than conventional therapies. DA replacement approaches enzyme expression slow However, therapies, such as adeno-associated virus (AAV)-glutamic acid decarboxylase (GAD) L-amino (AADC) increase transmitter have been demonstrated be safe efficient early-phase clinical trials. Disease-modifying strategies, progression, appear potent. These include therapies targeting downstream pathways, neurotrophic factors, midbrain DAnergic neuronal all shown preclinical focus on maintaining integrity neurons, just level itself. In particular, critical developmental maintenance Nurr1 Foxa2, can interact synergistically neighboring glia, paracrine mode action, protect against various toxic factors. Similar outcomes could achieved glial cells other candidate in-depth research needed. Neurotrophic neurturin, glial-cell-line-derived factor (GDNF), brain-derived (BDNF), vascular endothelial growth (VEGF), are also being investigated for their support neuron survival. Additionally, key autophagy-lysosome pathway, mitochondrial function, endoplasmic reticulum (ER) stress, offer avenues. Gene editing delivery techniques continue evolve, presenting new opportunities develop effective PD.

Language: Английский

Citations

2
Deciphering the role of heat shock protein HSPA1L: biomarker discovery and prognostic insights in Parkinson's disease and glioma DOI Creative Commons

Hong Cheng,

Jing Wang,

Yingjie Zhao

et al.

SLAS TECHNOLOGY, Journal Year: 2024, Volume and Issue: unknown, P. 100212 - 100212

Published: Oct. 1, 2024

Heat shock proteins (HSPs) play a critical role in cellular stress responses and have been implicated numerous diseases, including Parkinson's disease (PD) various cancers. Understanding the differential expression functional implications of HSPs these conditions is crucial for identifying potential therapeutic targets biomarkers diagnosis prognosis.

Language: Английский

Citations

1
Intranasal Administration of GRP78 Protein (HSPA5) Counteracts the Neurodegeneration in the Locus Coeruleus in a Model of Chronic Sleep Restriction in Rats DOI
М. Б. Пази, И. В. Екимова

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(4), P. 1630 - 1641

Published: July 1, 2024

Language: Английский

Citations

0
Intranasal administration of GRP78 protein (HSPA5) counteracts the neurodegeneration in the locus coeruleus in a model of chronic sleep restriction in rats DOI
М. Б. Пази, И. В. Екимова

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(8), P. 1238 - 1252

Published: Oct. 19, 2024

Chronic sleep restriction (sleep less than 6 hours per day) due to the workload and a decrease in quality is an endemic disease modern society. deprivation causes serious neuropsychiatric disorders associated with irreversible neurodegenerative changes brain. The search for pharmacological agents that can reduce risk of neurodegeneration as result chronic loss urgent task issue biomedicine. Intranasal administration glucose-regulated 78 kDa heat shock protein (GRP78) has neuroprotective effect rat model Parkinson´s disease. potential intranasally administered GRP78 not been previously studied. aim study find out whether preventive intranasal able weaken and/or stop process locus coeruleus (SR) rats. was conducted on months old male Wistar For deprivation, validated method swinging platform used mode: 3 1 hour rest continuously 5 days. Recombinant human two days before start SR during SR. Cellular molecular were studied using immunohistochemistry Western blotting. It shown leads degeneration 30% noradrenergic neurons coeruleus, increase levels activated caspases-3 9. This indicates development apoptosis along mitochondrial pathway. No signs reactive microgliosis found We have demonstrated penetrates accumulates counteracts death path apoptosis. data obtained allows consider agent prevention pathological consequences deprivation.

Language: Английский

Citations

0