Contribution of Sex Differences to Development of Cardiovascular Disease in Metabolic-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Lucy C. Taylor, Gertrude Arthur, Miguel Cruz

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 782 - 809

Published: Dec. 9, 2024

Sex differences are a complex and crucial variable in developing progressing metabolic cardiovascular disease pathophysiology clinical outcomes. The female sex, compared to the male is protected from disturbances their resulting events. However, peculiar life phases associated with females, such as puberty, pregnancy, premenopausal menopausal stages, all different risks for development of (CVD). Metabolic dysfunction-associated steatotic liver (MASLD), condition hepatic steatosis, at least one feature syndrome an increased risk MASLD its progression CVD differs between men women. Differences several factors, including formyl peptide receptor (FPR) 2, adipose tissue distribution, pyruvate kinase (LPK), ketone body production, may underlie sex MASLD-induced CVD. Understanding specific factors involved sexes crucial. This knowledge will provide important insights into mechanisms responsible complications can potentially lead therapeutics targeted explicitly each offering new hope fight against

Language: Английский

A validated liquid chromatography-tandem mass spectrometry assay for simultaneous quantitation of intact IGF-1 and IGF-2 in human serum DOI
Hao‐Long Zeng, Jie Lü, Huijun Li

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: unknown, P. 124572 - 124572

Published: March 1, 2025

Language: Английский

Citations

1
Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring DOI Creative Commons

Jiaye Liu,

Elham Kharazmi,

Qunfeng Liang

et al.

Leukemia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

In addition to biological factors, maternal exposures during pregnancy can contribute leukemogenesis in offspring. We conducted a population-based cohort study Sweden investigate the association between risk of acute lymphoblastic leukemia (ALL) offspring and anthropometrics pregnancy. A total 2,961,435 live-born singletons 1983-2018 were followed from birth ALL diagnosis, end age 18, or 2018. 1388 children diagnosed with (55.6% boys). observed an increased among daughters overweight/obese mothers early [Body mass index (BMI) ≥ 25 kg/m2; Standardized incidence ratio (SIR) = 1.4, 95% CI: 1.2-1.6] compared normal BMI. This was not found their sons (SIR 1.0, 0.9-1.1). Similar results for BMI before delivery. did find low high gestational weight gain (GWG) (both SIRs 1.0) male/female These suggest that overweight/obesity are important factors childhood daughters, whereas GWG is associated ALL. Further research on this mother-daughter may shed light possible sex hormone/chromosome-related etiology

Language: Английский

Citations

0
Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity DOI Creative Commons
Oleg Varlamov

Frontiers in Hematology, Journal Year: 2025, Volume and Issue: 4

Published: April 14, 2025

Maternal obesity, often linked to the consumption of a high-fat Western-style diet (WSD), poses significant risks both maternal and fetal health. This review explores impact obesity on hematopoietic stem progenitor cells (HSPCs), highlighting how metabolic inflammatory shifts in environment affect HSPC proliferation, differentiation, long-term immune system development. leads hormonal imbalances, increased cytokines, placental insufficiency, altered nutrient availability that disrupt normal function, potentially predisposing offspring dysfunction, disorders, cardiovascular diseases later life. Notably, skews differentiation toward myeloid lineage, which can impair adaptive responses increase risk autoimmune infections. Furthermore, diet-driven epigenetic transcriptional reprogramming HSPCs exacerbates chronic inflammation, reinforcing pro-inflammatory phenotype downstream progeny persists into postnatal stages. The also emphasizes need for further research clarify mechanisms underlying these effects across different species developmental stages, as well potential targeted interventions mitigate adverse impacts hematopoiesis lifelong health outcomes.

Language: Английский

Citations

0
Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies DOI Creative Commons
Xiaohong Liu, Juan Zhang, Ting Yi

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 18, 2025

Abstract Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti-angiogenesis targets tumors, with emphasis on molecular mechanisms signaling pathways that regulate this process. We emphasize microenvironment's role angiogenesis, examine endothelial cell metabolic changes, evaluated potential strategies targeting vascular system. At same time, we analyzed pathway mechanism angiogenesis detail. In addition, paper also looks at development trend drugs, including their future direction challenges, aiming to provide prospective insight into field. Despite potential, anti-angiogenic therapies encounter challenges like drug resistance side effects, necessitating ongoing research enhance cancer treatment efficacy these therapies.

Language: Английский

Citations

0
Mediating effect of osteocalcin underlying the link between insulin-like growth factor-I and gestational diabetes mellitus DOI Creative Commons
Lingling Cui, Yuting Gao,

Ruijie Sun

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 16, 2025

To investigate the associations of serum insulin like growth factor I (IGF-I) and Osteocalcin (OC) concentrations with gestational diabetes mellitus (GDM) risk among Chinese women. A case-control study was conducted in China, involving 125 GDM 153 healthy pregnant women at 24-28 weeks from 2019 to 2022. The approved by Clinical Trial Ethics Committee Third Afliated Hospital Zhengzhou University January 04, 2020, had been registered Registry (ChiCTR2000028811). Maternal IGF-I OC levels were measured second trimester. Logistic regression models restricted cubic spline (RCS) employed calculate association GDM, receiver operating characteristic (ROC) curves generated evaluate predictive capacity for GDM. Mediation analyses used mediation effect on between Both undercarboxylated (ucOC) concentration positively associated relationship is not linear (P-value < 0.001, P-Nonlinear 0.001). suggested that 48.61% might be mediated ucOC. areas under ROC integrated model 74.5% 76.2%. Serum provide a new dimension diagnosis clinical application, ucOC serve as mediator

Language: Английский

Citations

0
LCoRL regulates growth and metabolism DOI Creative Commons
Steven C. Wyler,

Surbhi Gahlot,

Lara Bideyan

et al.

Endocrinology, Journal Year: 2024, Volume and Issue: 165(12)

Published: Oct. 28, 2024

Abstract Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many these on homeostasis is largely unclear due to a lack detailed functional analyses. Here we report ligand-dependent corepressor-like (LCoRL) as regulator for body weight glucose homeostasis. Although GWAS data show that LCoRL strongly size, homeostasis, other traits livestock, investigations had not been performed. We generated Lcorl knockout mice (Lcorl−/−) characterized found Lcorl−/− pups are born smaller than wild-type (WT) littermates before reaching normal by 7 9 weeks age. While aging, remain lean compared WT mice, which decrease daily food intake. Glucose tolerance insulin sensitivity improved mice. Mechanistically, this stunted growth linked reduction circulating levels IGF-1. The expression downstream GH signaling involved lipid metabolism altered liver Furthermore, protected against high-fat diet challenge reduced exercise capacity an stress test. Collectively, our results congruent parameters locus reported livestock.

Language: Английский

Citations

2
Effects of dietary compound acidifier (Biomin) on the growth, anti-oxidation, immunity, and intestinal health of juvenile channel catfish (Ictalurus punctatus) DOI
Junyu Yan, Kai Luo,

Bo Wang

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 40, P. 102577 - 102577

Published: Dec. 24, 2024

Language: Английский

Citations

2
Contribution of Sex Differences to Development of Cardiovascular Disease in Metabolic-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Lucy C. Taylor, Gertrude Arthur, Miguel Cruz

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 782 - 809

Published: Dec. 9, 2024

Sex differences are a complex and crucial variable in developing progressing metabolic cardiovascular disease pathophysiology clinical outcomes. The female sex, compared to the male is protected from disturbances their resulting events. However, peculiar life phases associated with females, such as puberty, pregnancy, premenopausal menopausal stages, all different risks for development of (CVD). Metabolic dysfunction-associated steatotic liver (MASLD), condition hepatic steatosis, at least one feature syndrome an increased risk MASLD its progression CVD differs between men women. Differences several factors, including formyl peptide receptor (FPR) 2, adipose tissue distribution, pyruvate kinase (LPK), ketone body production, may underlie sex MASLD-induced CVD. Understanding specific factors involved sexes crucial. This knowledge will provide important insights into mechanisms responsible complications can potentially lead therapeutics targeted explicitly each offering new hope fight against

Language: Английский

Citations

1