Albumin Is an Integrative Protein of Blood Plasma and Beyond DOI Open Access
Daria A. Belinskaia,

Richard O. Jenkins,

Н. В. Гончаров

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12627 - 12627

Published: Nov. 25, 2024

Albumin is a major protein in mammalian blood plasma or serum, where its concentration healthy organisms about 600 μM [...].

Language: Английский

Nitroxide radical contrast agents for safe magnetic resonance imaging: progress, challenges, and perspectives DOI
Xiaobing Yuan, Haojie Yu, Li Wang

et al.

Materials Horizons, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Magnetic resonance imaging (MRI) is considered one of the most valuable diagnostic technologies in 21st century. To enhance image contrast anatomical features, MRI agents have been widely used clinical diagnosis, especially those based on gadolinium, manganese, and iron oxide. However, these metal-based show potential toxicity to patients, which urges researchers develop novel that can replace agents. Metal-free nitroxide radical (NRCAs) effectively overcome shortcomings also many advantages, including good biocompatibility, prolonged systemic circulation time, easily functionalized structures. Importantly, since NRCAs acquire signals with standard tissue water

Language: Английский

Citations

1
Towards Metabolic Organic Radical Contrast Agents (mORCAs) for Magnetic Resonance Imaging DOI Creative Commons
Shuyang Zhang,

Sabina Dhakal,

Evan T. Curtis

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1581 - 1581

Published: April 2, 2025

We report two conjugates of gem-diethyl pyrroline nitroxide radicals with D-mannosamine as potential metabolic organic radical contrast agents, mORCAs, circumventing the need for biorthogonal reactions. In-cell EPR spectroscopy, using Jurkat cells and analogous conjugate, based on a pyrrolidine radical, shows an efficient incorporation highly immobilized nitroxides, correlation time τcor = 20 ns. In vivo MRI experiments in mice show that paramagnetic shortens T1 T2 relaxation times protons water located kidney brain by only up to ~10% after 3 d. Ex spectroscopic analyses indicate agents mouse tissues are primarily localized kidney, lung, liver, heart, blood, which contain 4–9 The spin concentrations remain low (1–3 nmol g⁻1) at 24 h third mORCA injection, approximately one orders magnitude lower than those ORCAFluor BASP-ORCA (measured ~24 post-injection). These explain small proton changes observed MRI.

Language: Английский

Citations

0
Research Progress of Nitroxide Radical-Based MRI Contrast Agents: From Structure Design to Application DOI

Tao Luo,

Bo Wang,

R. Chen

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nitroxide radicals-based agnetic resonance imaging remains a cornerstone of diagnostic imaging, offering unparalleled insights into anatomical structures and pathological conditions.

Language: Английский

Citations

3
Advances in chemically modified HSA as a multifunctional carrier for transforming cancer therapy regimens DOI
Zheng Sun, Hui Fu,

Ruixuan Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141373 - 141373

Published: Feb. 21, 2025

Language: Английский

Citations

0
Albumin Is an Integrative Protein of Blood Plasma and Beyond DOI Open Access
Daria A. Belinskaia,

Richard O. Jenkins,

Н. В. Гончаров

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12627 - 12627

Published: Nov. 25, 2024

Albumin is a major protein in mammalian blood plasma or serum, where its concentration healthy organisms about 600 μM [...].

Language: Английский

Citations

1