Unraveling the clinical–pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer’s Coordinating Center dataset DOI Creative Commons

Satomi Hiya,

Carolina Maldonado‐Díaz,

Susan Rohde

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, presence of multiple comorbid neuropathologies increasingly being recognized as a major contributor to worldwide dementia burden. We analyzed 1051 subjects with specific combinations isolated and mixed pathologies conducted multivariate logistic regression analysis on cohort 4624 cases systematically explore independent cognitive contributions each pathology. limbic-predominant age-related TDP-43 encephalopathy (LATE-NC) were both associated primary diagnosis (AD) characterized by an amnestic phenotype, while only ADNC logopenic variant progressive aphasia (PPA). In LATE-NC, Lewy body disease, and/or cerebrovascular phenotype was usually diagnosed during life “Probable AD.” Conversely, combination frontotemporal lobar degeneration TDP-43, supranuclear palsy (PSP), or corticobasal (CBD) resulted in picture, variable features PPA subtypes, behavioral FTD, PSP syndrome, CBD syndrome. These findings elucidate cumulative effects provide insights into interactions between neurodegenerative contributing variety presentations.

Language: Английский

Prevalence of mixed neuropathologies in age‐related neurodegenerative diseases: A community‐based autopsy study in China DOI Creative Commons
Xiaoxi Wang, Keqing Zhu, Wei Wu

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 25, 2024

Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples Chinese banks. A total of 1142 brains six banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations neurological disorders analyzed. Significant proportions displayed primary age-related tauopathy (PART, 35%), limbic-predominant TDP-43 encephalopathy (LATE, 46%), aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body (LBD, 13%), cerebrovascular (CVD, 63%) also prevalent, often co-occurring regional variations. CVD emerged as the potential most early contributor changes. analysis highlights prevalence PART, LATE, ARTAG, ADNC, LBD, CVD, differences. The findings suggest may be earliest contributing factor, potentially preceding other neuropathologies. Highlights (PART), (LATE), (ARTAG), neuropathologic change, disease, (CVD) in China, increasing age, is comparable countries. differences prevalences diseases noted. develops prior any disorders, including ARTAG.

Language: Английский

Citations

4
The Autonomic-Cognition Clinical Correlation in Indonesian Parkinson’s Disease Subjects DOI Creative Commons

Abraham Al Jody,

Amanda Tiksnadi,

Margareth Hildaria

et al.

Proceedings Book of The International Conference and Exhibition on The Indonesian Medical Education Research Institute., Journal Year: 2025, Volume and Issue: 8(-), P. 48 - 64

Published: Jan. 17, 2025

Background: Dysautonomia and cognitive impairment are common in PD, affecting quality of life disease progression. Understanding their connection enables earlier identification at-risk patients. This study investigates the correlation between dysautonomia Indonesian PD Methods Materials: cross-sectional collected demographic clinical data, including SCOPA-COG INA SCOPA-AUT INA. Independent t-tests, Mann-Whitney U tests, Pearson’s, Spearman’s tests analyzed associations. Results: We recruited 33 subjects, primarily male (72.7%) elderly (63.6%). The median age was 61 years, with 60.6% having a duration at least 5 years 66.7% mild stage. Median levodopa equivalent daily dose (LEDD) 325 mg. were 24 17. Cognitive present 45.4%, 15.2%. Elderly subjects had lower (20.19±7.18 vs 27.58±5.98). Cognitively impaired worse (20.6±7.81 vs. 13.89±6.43) higher LEDD (408.33±140.25 275.28±134.51). urinary symptoms (p<0.05). No differences found without or when divided by significantly correlated (ρ = -0.368, p < 0.05), as memory domain cardiovascular 0.399, 0.05). Conclusion: In patients, is dysautonomia. Age, onset, associated but not Further exploration could enhance understanding this correlation.

Language: Английский

Citations

0
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies DOI Creative Commons
Yuriko Katsumata,

Xian Wu,

Khine Zin Aung

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Nov. 15, 2024

Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describe brains with LATE-NC but lacking intermediate or severe levels of Alzheimer's disease (ADNC). Focusing on pure LATE-NC, we analyzed data from the National Coordinating Center (NACC) Neuropathology Data Set, comprising clinical and pathological information aggregated 32 NIH-funded Disease Research Centers (ADRCs). After excluding subjects dying unusual conditions, n = 1,926 autopsied were included in analyses. For > 90% these participants, apolipoprotein E (APOE) allele status was known; 46.5% had at least one APOE 4 allele. In most human populations, only 15–25% people are ε4 carriers. ADRCs higher documented AD risk (APOE BIN1) rates fewer participants ADNC, correspondingly low LATE-NC. Among non-carries, 5.3% 37.0% 3.6% neocortical Lewy body pathology. terms impact, tended die after having received diagnosis dementia: 56% died dementia among non-carrier comparable 61% ADNC. associated increased Clinical Dementia Rating Sum Boxes (CDR-SOB) scores, i.e. worsened global cognitive impairments, no/low ADNC no pathology (p 0.0023). cases, there trend for stages be worse CDR-SOB scores 0.026 linear stages). not features disinhibition primary progressive aphasia. summary, less frequent than rare, particularly individuals who lacked allele, study cohorts frequencies similar those populations.

Language: Английский

Citations

2
Alcohol consumers with liver pathology rarely display α-synuclein pathology DOI Creative Commons
Sylwia Libard, Fredrik Tamsen, Irina Alafuzoff

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 148(1)

Published: Aug. 1, 2024

Abstract It has been suggested that alcohol consumption protects against Parkinson's disease (PD). Here we assessed postmortem tissue samples from the brains and livers of 100 subjects with ages at death ranging 51 to 93. Twenty percent these were demented. We used standardized assessment strategies assess both brain liver pathologies (LP). Our cohort included none, mild, moderate, severe LP caused by consumption. noted a significant negative correlation categorical data between steatosis α-synuclein (αS) in extent fibrosis αS brain. There was association observation Alzheimer’s type II astrocytes pathology No hyperphosphorylated τ (HPτ). could be seen HPτ, amyloid β protein (Aβ) or transactive DNA binding 43 (TDP43) correlations observed Aβ, αS, TDP43 steatosis, inflammation, fibrosis. Subjects displayed higher frequency compared those no, LP. The alterations not more prevalent In all cases, dementia attributed combination altered proteins, i.e., mixed 30% mild when 13% summary, our results are line outcome obtained two recent meta-analyses suggesting history seldom develop an α-synucleinopathy.

Language: Английский

Citations

1
Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer’s Disease DOI
Kelly Del Tredici, Michael P. Schön, Simone Feldengut

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 101(4), P. 1333 - 1353

Published: Sept. 20, 2024

Neuropathologic studies of brains from autopsy series show tau inclusions (pretangles, neuropils threads, neurofibrillary tangles) are detectable more than a decade before amyloid-β (Aβ) deposition in Alzheimer's disease (AD) and develop characteristic manner that forms the basis for AD staging. An alternative position views pathological without Aβ as 'primary age-related tauopathy' (PART) rather prodromal AD. Recently, an early focus Ammon's horn second sector (CA2) with relative sparing CA1 occurs entorhinal cortex (EC) was proposed additional feature PART.

Language: Английский

Citations

0
Unraveling the clinical–pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer’s Coordinating Center dataset DOI Creative Commons

Satomi Hiya,

Carolina Maldonado‐Díaz,

Susan Rohde

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, presence of multiple comorbid neuropathologies increasingly being recognized as a major contributor to worldwide dementia burden. We analyzed 1051 subjects with specific combinations isolated and mixed pathologies conducted multivariate logistic regression analysis on cohort 4624 cases systematically explore independent cognitive contributions each pathology. limbic-predominant age-related TDP-43 encephalopathy (LATE-NC) were both associated primary diagnosis (AD) characterized by an amnestic phenotype, while only ADNC logopenic variant progressive aphasia (PPA). In LATE-NC, Lewy body disease, and/or cerebrovascular phenotype was usually diagnosed during life “Probable AD.” Conversely, combination frontotemporal lobar degeneration TDP-43, supranuclear palsy (PSP), or corticobasal (CBD) resulted in picture, variable features PPA subtypes, behavioral FTD, PSP syndrome, CBD syndrome. These findings elucidate cumulative effects provide insights into interactions between neurodegenerative contributing variety presentations.

Language: Английский

Citations

0