Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Language: Английский

Effects and mechanisms of water extract of Uraria crinit a on manganese chloride-induced apoptosis in SH-SY5Y cells DOI Creative Commons
Jin‐Tung Liang,

Weiwei Yin,

Duanzhuo Li

et al.

CyTA - Journal of Food, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0
Inhibiting Cell Inspection Points Intervention Via Injectable Short Fibers for Reversing Neural Cell Senescence DOI
Qianyi Li, Liang Chen, Jie Yu

et al.

Advanced Fiber Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Toxic Effects and Mechanism of Cadmium-Induced Oxidative Damage in Neuronal Cells DOI

Zhu-Zhong Mei,

Jie Yang, Yuan Zhao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson’s Disease Management DOI Creative Commons

Vitória Farina Azzolin,

Verônica Farina Azzolin, Euler Esteves Ribeiro

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 348 - 348

Published: March 15, 2025

Parkinson's disease (PD) is a progressive neurodegenerative disorder linked to oxidative stress, mitochondrial dysfunction, and neuroinflammation. This study evaluates the neurofunctional immunomodulatory effects of an aqueous extract combining cocoa seed husk guarana powder (GuaCa). Eighteen extracts were characterized by flavonoid polyphenol content, antioxidant activity, genoprotective potential. The HCE3 extract, rich in catechins, quercetin, epigallocatechin gallate, was selected for further analysis three models: Eisenia fetida earthworms, SH-SY5Y neuron-like cells, peripheral blood mononuclear cells (PBMCs) from PD patients. showed activity contained flavonoid. No significant toxicity observed fetida. In GuaCa increased cell viability brain-derived neurotrophic factor (BDNF) levels reduced damage lowering extracellular NDUSF7 (subunit NADH dehydrogenase (ubiquinone) complex) levels. dPD-PBMCs cultures, pro-inflammatory cytokine IL-6 levels, indicating effects. shows promise as nutraceutical managing neuroinflammation dysfunction PD. Further clinical studies are needed confirm efficacy potential neuroprotective dietary strategies.

Language: Английский

Citations

0
FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114524 - 114524

Published: March 1, 2025

Language: Английский

Citations

0
Intestinal dysbiosis leads to the reduction in neurochemical production in Parkinson’s disease (PD) DOI
Rahul Kumar, Rahul Kumar

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Drosophila model systems reveal intestinal stem cells as key players in aging DOI

Joung‐Sun Park,

Mi Jeong Sung,

Hyun‐Jin Na

et al.

Annals of the New York Academy of Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract The intestines play important roles in responding immediately and dynamically to food intake, environmental stress, metabolic dysfunction, they are involved various human diseases aging. A key part of their function is governed by intestinal stem cells (ISCs); therefore, understanding ISCs vital. Dysregulation ISC activity, which influenced cell signaling pathways signals, can lead inflammatory responses, tissue damage, increased cancer susceptibility. Aging exacerbates these dynamics affects elasticity. Additionally, proliferation differentiation profoundly affect behavior gut health, highlighting the complex interplay between factors homeostasis. Drosophila models help us understand regulatory networks gut, providing valuable insights into disease mechanisms therapeutic strategies targeting diseases.

Language: Английский

Citations

0
Linking Environmental Genotoxins to Neurodegenerative Diseases Through Transcriptional Mutagenesis DOI Open Access
Bert M. Verheijen, Marc Vermulst

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11429 - 11429

Published: Oct. 24, 2024

Numerous lines of evidence suggest that DNA damage contributes to the initiation, progression, and severity neurodegenerative diseases. However, molecular mechanisms responsible for this relationship remain unclear. This review integrates historical data with contemporary findings propose exacerbates diseases by inducing transcription errors. First, we describe scientific rationale basic biological concepts underpin hypothesis. Then, provide epidemiological, cellular, support idea, new recently published observations former high incidence disease in Guam may have been driven damage-induced Finally, explore long-term implications these on our understanding impact genotoxic stress human aging disease.

Language: Английский

Citations

1
Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Language: Английский

Citations

0