The Role of Gut Microbiota in Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) DOI Creative Commons
Săndica Bucurică

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Gut microbiota plays a critical role in developing and progressing metabolic dysfunction-associated steatotic liver disease (MASLD). Studies show reduced microbial diversity specific shifts bacterial populations MASLD patients, with harmful species increasing beneficial ones decreasing. These changes contribute to fat accumulation by impairing fiber fermentation, disrupting bile acid metabolism, intestinal permeability, promoting inflammation. The progression of is linked evolving changes, probiotics like Lactobacillus plantarum potential mitigating restoring gut balance. Thus, serves as both key factor therapeutic target MASLD. Interventions on are possible targets treating or preventing toward advanced stages. At the same time, prebiotics have shown results ameliorating MASLD, post-biotic therapy, immuno-nutrition, bacteria engineering, phages, which been applied only experimental studies.

Language: Английский

Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma DOI Creative Commons
Mahmoud Zhra, Muhammad Affan Elahi, Aamira Tariq

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 466 - 466

Published: March 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Language: Английский

Citations

0
Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair DOI Creative Commons

Jiali Liang,

Wanqing Liu, Tong Zhang

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 7, 2025

Abstract The appearance of DNA damage often involves the participation related enzymes, which can affect onset and development various diseases. Several natural active compounds have been found to efficiently adjust activity crucial enzymes associated with single or double-strand damage, thus demonstrating their promise in treating This paper provides an in-depth examination summary these modulation mechanisms, leading a thorough review subject. connection between disease is explored through analysis structural characteristics compounds. By reviewing how different scholarly sources describe identical structures using varied terminology, this study also delves into effects on enzyme regulation. offers potentially be used therapeutically influence key activities expression levels, turn process repair (DDR). These shown not only reduce occurrence but boost efficiency processes, presenting new therapeutic opportunities for conditions such as cancer other pathologies. Future research should focus clarifying exact mechanisms maximize clinical utility support creation novel approaches prevention treatment. Graphical abstract

Language: Английский

Citations

0
Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients DOI Creative Commons
Săndica Bucurică,

Andreea Simona Nancoff,

Mădălina Duţu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1686 - 1686

Published: July 29, 2024

Anomalies in lipid metabolism involve multifactorial pathogenesis, among other factors, being associated with an inflammatory state and disturbances vitamin D status. The literature has focused on the binary relationships between inflammation dyslipidemia, or inflammation. Our study aimed to explore link all these three factors: 25-OH serum levels, presence of assessed through C-reactive protein (CRP), profile 2747 hospitalized patients. results showed a positive correlation HDL-C 25 (OH) negative CRP. This relationship had different patterns statistical network analysis. analysis are preserved for males females, except CRP D, which is present male cases absent females. same triangular three-CRP, was found strengths partial obese non-obese pattern similar patients without fatty liver. A shifted hypertensive negatively correlated HDL-C, positively non-hypertensive Castelli's Risk indexes I II were CRP, suggesting that increased cardiovascular risk proportional state. triad formed by altered inflammation, represents complex marked specific dynamics lipidic fractions such as D.

Language: Английский

Citations

3
Correlation Between Thrombin Generation and Hepatic Fibrosis in Chronic Liver Diseases DOI Open Access
Liliana Vecerzan, Ionela Maniu,

Gabriela Cioca

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

Hepatic stellate cells (HSC) are recruited to the site of injury in liver tissue repair mechanism, and changes HSC undergo reflect paracrine stimulation by all cell types (sinusoidal endothelial cells, Kupffer hepatocytes, platelets, leukocytes). This study aimed analyse a possible correlation between degree fibrosis thrombin generation patients with chronic diseases. Background Coagulation disorders disease continue challenge clinicians. A more accurate assessment coagulation cascade is provided investigating production individuals varying degrees fibrosis. Methods prospective observational pilot was done on hospitalized Thrombin from their platelet-poor plasma studied assessed transient elastography versus that control subjects. Results The peak significantly higher those severe stiffness (F3) than advanced fibrosis/liver cirrhosis (F4). Also, total concentration formed time interval (area under curve (AUC)) velocity index (VI) F3 F4. Conclusion decreases progression

Language: Английский

Citations

0
The Role of Gut Microbiota in Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD) DOI Creative Commons
Săndica Bucurică

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Gut microbiota plays a critical role in developing and progressing metabolic dysfunction-associated steatotic liver disease (MASLD). Studies show reduced microbial diversity specific shifts bacterial populations MASLD patients, with harmful species increasing beneficial ones decreasing. These changes contribute to fat accumulation by impairing fiber fermentation, disrupting bile acid metabolism, intestinal permeability, promoting inflammation. The progression of is linked evolving changes, probiotics like Lactobacillus plantarum potential mitigating restoring gut balance. Thus, serves as both key factor therapeutic target MASLD. Interventions on are possible targets treating or preventing toward advanced stages. At the same time, prebiotics have shown results ameliorating MASLD, post-biotic therapy, immuno-nutrition, bacteria engineering, phages, which been applied only experimental studies.

Language: Английский

Citations

0