Antimicrobial Profile from Frog Skin Peptides DOI

Chi Yan,

Yu Zhang, Xuejiang Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Abstract This study evaluates the antimicrobial efficacy of frog skin-derived peptides Magainin 1, 2, and Bombesin against Bacillus subtilis, Escherichia coli, Trichoderma harzianum . Experimental setups involved uniform inoculation microorganisms on 20 mL agar plates, treated with varying volumes (1.5 µL, 5 10 µL) each peptide (10 mg/mL). For subtilis , demonstrated significant antibacterial activity, inhibition zones increasing in size proportionally to volumes. 2 showed highest efficacy, surpassing ampicillin at higher In coli similar dose-dependent effects were observed, again showing superior performance, matching or exceeding ampicillin. Notably, exhibited antifungal activity Amphotericin resistance. These show inhibitory fungi, gram-positive than gram-negative bacteria. findings highlight potential as agents except 1.

Language: Английский

Investigation of the Mechanism of Action of AMPs from Amphibians to Identify Bacterial Protein Targets for Therapeutic Applications DOI Creative Commons
Carolina Canè,

Lidia Tammaro,

Angela Duilio

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1076 - 1076

Published: Nov. 12, 2024

Antimicrobial peptides (AMPs) from amphibians represent a promising source of novel antibacterial agents due to their potent and broad-spectrum antimicrobial activity, which positions them as valid alternatives conventional antibiotics. This review provides comprehensive analysis the mechanisms through amphibian-derived AMPs exert effects against bacterial pathogens. We focus on identification protein targets implicated in action these biological processes altered by effect AMPs. By examining recent advances countering multidrug-resistant bacteria multi-omics approaches, we elucidate how interact with membranes, enter cells, target specific protein. discuss implications interactions developing targeted therapies overcoming antibiotic resistance (ABR). aims integrate current knowledge AMPs’ mechanisms, identify gaps our understanding, propose future directions for research harness amphibian clinical applications.

Language: Английский

Citations

2
Antimicrobial Profile from Frog Skin Peptides DOI

Chi Yan,

Yu Zhang, Xuejiang Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Abstract This study evaluates the antimicrobial efficacy of frog skin-derived peptides Magainin 1, 2, and Bombesin against Bacillus subtilis, Escherichia coli, Trichoderma harzianum . Experimental setups involved uniform inoculation microorganisms on 20 mL agar plates, treated with varying volumes (1.5 µL, 5 10 µL) each peptide (10 mg/mL). For subtilis , demonstrated significant antibacterial activity, inhibition zones increasing in size proportionally to volumes. 2 showed highest efficacy, surpassing ampicillin at higher In coli similar dose-dependent effects were observed, again showing superior performance, matching or exceeding ampicillin. Notably, exhibited antifungal activity Amphotericin resistance. These show inhibitory fungi, gram-positive than gram-negative bacteria. findings highlight potential as agents except 1.

Language: Английский

Citations

0