Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

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Lipotoxicity, lipid peroxidation and ferroptosis: a dilemma in cancer therapy

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 26, 2025

Abstract The vulnerability of tumor cells to lipid peroxidation, driven by redox imbalance and overabundance within the microenvironment (TME), has become a focal point for novel antitumor strategies. Ferroptosis, form regulated cell death predicated on is emerging as promising approach. Beyond their role in directly eliminating cells, peroxidation its products, such 4-hydroxynonenal (HNE), exert an additional influence damaging DNA shaping environment conducive growth metastasis. This process polarizes macrophages towards pro-inflammatory phenotype, dampens antigen-presenting capacity dendritic (DCs), undermines cytotoxic functions T NK cells. Furthermore, it transforms neutrophils into pro-tumorigenic polymorphonuclear myeloid-derived suppressor (PMN-MDSCs). stroma also contributes progression. Although advanced nanotherapies have shown ability target precisely, they often overlook nuanced effects products. In this review, we highlight synergistic mechanism which products ferroptosis contribute immunosuppressive state that temporally distinct from death. insight broadens our understanding ferroptosis-derived immunosuppression, encompassing all types immune TME. review aims catalyze further research underexplored area, emphasizing potential hinder clinical translation ferroptosis-based therapies. Graphical abstract

Language: Английский

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Synergistic Inhibition of Colon Cancer Cell Proliferation via p53, Bax, and Bcl-2 Modulation by Curcumin and Plumbagin Combination

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

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Identification of a biomarker to predict doxorubicin/cisplatin chemotherapy efficacy in osteosarcoma patients using primary, recurrent and metastatic specimens

Translational Oncology, Journal Year: 2024, Volume and Issue: 49, P. 102098 - 102098

Published: Aug. 16, 2024

Doxorubicin and cisplatin are both first-line chemotherapeutics for osteosarcoma (OS) treatment. However, the efficacy of doxorubicin/cisplatin chemotherapy varies considerably. Thus, identifying an efficient diagnostic biomarker to distinguish patients with good poor responses is paramount importance.

Language: Английский

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H. pectinata (L.) Poit - Traditional uses, phytochemistry and biological-pharmacological activities in preclinical studies: A systematic review

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118478 - 118478

Published: June 21, 2024

Language: Английский

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