Exosome-Mediated Cellular Communication in the Tumor Microenvironment Imparts Drug Resistance in Breast Cancer

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1167 - 1167

Published: March 30, 2025

Globally, breast cancer (BC) is the leading cause of cancer-related death for women. BC characterized by heterogeneity, aggressive behavior, and high metastatic potential. Chemotherapy, administered as monotherapy or adjuvant therapy, remains a cornerstone treatment; however, acquired drug resistance significant clinical challenge. Deciphering mechanisms will be central to developing more efficient treatment options improving patient outcomes. The current review examines multifaceted nature exosomes in conferring through complex communication networks within tumor microenvironment. We further explore recent advances understanding how contribute against established chemotherapeutic agents such tamoxifen, paclitaxel, doxorubicin, platinum-based drugs, trastuzumab, newer immunotherapies, immune checkpoint inhibitors. Moreover, we discuss existing systematic approaches investigating exosome-drug relationship BC. Finally, promising therapeutic overcome exosome-dependent BC, highlighting potential avenues improved efficacy. Investigating distinct functions cargo offers innovative overcoming resistance.

Language: Английский

---

Advances in the roles and molecular mechanisms of exosomal circular RNAs in regulating the pre-metastatic niche of tumors

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 19, 2025

Metastasis remains a major cause of morbidity and mortality in patients with malignant tumors. The pre-metastatic niche is prerequisite for distant metastasis driven by primary Circular RNAs (circRNAs), class single-stranded closed non-coding RNAs, exhibit high stability, evolutionary conservation, cell-type specificity. Exosomes, as natural carriers circRNAs, mediate intercellular communication contribute to the formation niche; however, mechanisms which they do so remain incompletely understood. This review summarizes biological characteristics functions exosomal circRNAs outlines molecular pathways through shape tumor microenvironment, emphasis on immunosuppression, vascular permeability, extracellular matrix remodeling, lymphangiogenesis. first focus functional roles regulation, providing basis development therapeutic strategies targeting metastatic progression.

Language: Английский

---

Tumor-derived exosomes as promising tools for cancer diagnosis and therapy

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Mounting evidences indicated that cancer cell-derived exosomes (TDEs) contribute to progression and metastasis by reshaping the tumor microenvironment (TME) interfering immunity response. TDEs contain unique biomolecular cargo, consisting of protein, nucleic acid, lipids. In recent years, have been used as potential disease therapeutics diagnosis biomarkers prime candidates delivery tools for treatment. present review, we firstly summarized biogenesis characteristic. Also, role in cell invasiveness, drug resistance, immunosuppression was mentioned via cell-cell communication. Additionally, concluded current strategies TDE-based therapy, including inhibition clearance, usage therapeutic vector vaccines. Furthermore, combination therapy with engineered were summarized, such radiotherapy, photodynamic photothermal sonodynamic therapy. Consequently, above opens up novel interesting opportunities prognosis based on TDEs, which is prospective accelerate clinical translation

Language: Английский

---

ECM1 and ANXA1 in urinary extracellular vesicles serve as biomarkers for breast cancer

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 8, 2024

Objective Although urinary extracellular vesicles (uEVs) have been extensively studied in various cancers, their involvement breast cancer (BC) remains largely unexplored. The non-invasive nature of urine as a biofluid and its abundant protein content offer considerable potential for the early detection cancer. Methods This study analyzed proteomic profiles uEVs from BC patients healthy controls (HC). dysregulation ECM1 ANXA1 was validated larger cohort 128 patients, 25 HC benign nodules (BBN) by chemiluminescence assay (CLIA). expression levels were also confirmed MMTV-PyMT transgenic mouse models. Results LC-MS/MS analysis identified 571 dysregulated proteins patients. selected validation BBN using CLIA, fold change showed significant difference more than 10 with p -value<0.05. Protein significantly increased In addition, mice observed to increase progressively progression Conclusion We developed simple purification-free platform isolate quantitatively detect WGA-coupled magnetic beads CLIA. Our results suggest that could potentially serve diagnostic biomarkers

Language: Английский

---