Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 28, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106688 - 106688
Published: Feb. 1, 2025
Language: Английский
Citations
0
Microcirculation, Journal Year: 2025, Volume and Issue: 32(2)
Published: Feb. 1, 2025
ABSTRACT Objective Lymphatic vessels and blood have some similarities in structure, but they distinct contraction characteristics functions. Revealing the detailed transcriptional differences of lymphatic, artery vein are required for circulation research. Methods The tissues mesenteric artery, were collected from Wistar rats. transcriptome signatures these RNA‐seq (RNA sequencing) analyzed using bioinformatic methods. Results GO (gene ontology) enrichment showed three gene expression patterns extracellular matrix, cell adhesion molecule binding, receptor ligand activity, contractile fiber. genes involved contractility also differently expressed, which enriched into KEGG (Kyoto Encyclopedia Genes Genomes) pathways cytoskeleton muscle cells, vascular smooth contraction, renin‐angiotensin system. Through PPI (protein–protein interaction) analysis, we identified 43 expressed hub tissues. Thirty‐four transcription factors cofactors as important normal function Furthermore, screened out 20 potential marker each tissue. Conclusions Our study described vein, shedding light on mechanisms These results provided therapeutic targets diseases markers lymphatic vessel studies.
Language: Английский
Citations
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Medicine, Journal Year: 2025, Volume and Issue: 104(13), P. e41972 - e41972
Published: March 28, 2025
Cardiovascular disease (CVD) represents a global problem and is associated with high levels of morbidity/mortality in the elderly (>65 years old). The present study aimed to identify key candidate genes pathways cardiac aging via integrated bioinformatics analysis. GSE43556 GSE8146 gene expression datasets were obtained from Gene Expression Omnibus (GEO) database, differentially expressed (DEGs), defined as P < .05 |log fold-change (FC)| >0.5, identified. Functional enrichment protein-protein interaction network construction subsequently performed. First, 142 DEGs shared between two GEO Second, biological functional analysis illustrated that these mainly participate “inflammatory response” “monocarboxylic acid metabolic process.” Moreover, Kyoto Encyclopedia Genes Genomes pathway revealed enriched PI3K-Akt signaling pathway. Subsequently, association aged heart was evaluated using Search Tool for Retrieval Interacting database Cytoscape software. elucidated aging, thus improving understanding molecular mechanisms underlying aging. These identified may be used biomarkers diagnosis treatment
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113995 - 113995
Published: April 1, 2025
Language: Английский
Citations
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Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5649 - 5663
Published: Oct. 1, 2024
The occurrence and development of tumors in human tissues widely depend on their surrounding environment, known as the tumor microenvironment (TME), which comprises various cells, molecules, blood vessels. Through modifications, organization, integration, these elements serve potential therapeutic targets anti-cancer therapy, supporting promoting proliferation, invasion, metabolism cells. Cytokines within TME are responsible for immune cell activation, differentiation, thereby influencing tumor's behavior. This article reviews use cytokines immunotherapy combs network signals that mediate malignancies.
Language: Английский
Citations
2
Published: June 3, 2024
Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence increasing worldwide parallel with obesity pandemic. A lack of insulin or resistance, consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) a long-term complication central nervous system (CNS), characterized by cognitive impairment motor dysfunctions. The role oxidative stress neuroinflammation pathomechanism DE has been proven. Fractalkine (CX3CL1) unique properties as an adhesion molecule chemoattractant, acting on only receptor, CX3CR1, it regulates activity microglia physiological states neuroinflammation. Depending clinical context, CX3CL1-CX3CR1 signaling may have neuroprotective effects inhibiting inflammatory process or, conversely, maintaining/intensifying inflammation neurotoxicity. This review discusses evidence supporting that pair other neurotoxic. Interrupting vicious cycle within neuron-microglia interactions be therapeutic goal limiting response.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135689 - 135689
Published: Sept. 1, 2024
Language: Английский
Citations
1
Human Genomics, Journal Year: 2024, Volume and Issue: 18(1)
Published: June 17, 2024
Abstract Background Human cytomegalovirus (HCMV) is a herpesvirus that can infect various cell types and modulate host gene expression immune response. It has been associated with the pathogenesis of cancers, but its molecular mechanisms remain elusive. Methods We comprehensively analyzed HCMV pathway genes across 26 cancer using Cancer Genome Atlas (TCGA) The Genotype-Tissue Expression (GTEx) databases. also used bioinformatics tools to study invasion tumor microenvironment in pan-cancer. Cox regression machine learning were analyze prognostic their relationship drug sensitivity. Results found are widely expressed cancers. Immune infiltration revealed involved complex processes. obtained for 25 cancers significantly 23 key pathway, which enriched cellular chemotaxis synaptic function may be disease progression. Notably, CaM family up-regulated AC down-regulated most tumors. These hub correlate sensitivity or resistance drugs, suggesting potential as therapeutic targets. Conclusions Our role provided insights into mechanism significance. worth noting open up new doors prevention treatment.
Language: Английский
Citations
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International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7527 - 7527
Published: July 9, 2024
Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence increasing worldwide parallel with obesity pandemic. A lack of insulin or resistance, consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) a long-term complication central nervous system (CNS), characterized by cognitive impairment motor dysfunctions. The role oxidative stress neuroinflammation pathomechanism DE has been proven. Fractalkine (CX3CL1) unique properties as an adhesion molecule chemoattractant, acting on only receptor, CX3CR1, it regulates activity microglia physiological states neuroinflammation. Depending clinical context, CX3CL1-CX3CR1 signaling may have neuroprotective effects inhibiting inflammatory process or, conversely, maintaining/intensifying inflammation neurotoxicity. This review discusses evidence supporting that pair other neurotoxic. Therefore, interrupting vicious cycle within neuron–microglia interactions promoting neurotoxic axis be therapeutic goal limiting response. However, optimal approach prevent simply tight glycemic control, because elimination dysglycemic CNS abolishes fundamental mechanisms induce this cycle.
Language: Английский
Citations
0