Association between dietary patterns and suicide ideation among depressed adults: Insights from NHANES 2007–2020

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 377, P. 235 - 244

Published: Feb. 21, 2025

Language: Английский

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Omega-3 Fatty Acids for the Treatment of Bipolar Disorder Symptoms: A Narrative Review of the Current Clinical Evidence

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 84 - 84

Published: Feb. 15, 2025

Bipolar disorder is a chronic mental disease that characterized by depressive and manic episodes. Antipsychotics mood stabilizers are known therapies work, but their restrictions disadvantages resulted in the need for complementary alternative therapies, such as natural compounds. Omega-3 fatty acids, basic ingredients of fishes seafood, play crucial roles brain development, function membrane enzymes, learning, many other instances, deficiency has been associated with diseases, including bipolar disorder. The present narrative review aims to critically summarize scrutinize available clinical studies on use omega-3 acids management co-treatment episodes symptoms. For this purpose, thorough in-depth search was performed most accurate scientific databases, e.g., PubMed., Scopus, Web Science, Cochrane, Embase, Google Scholar, applying effective relevant keywords. There currently several assessed effect severity BD Some them supported evidence potential beneficial impact supplementation prevention and/or symptomatology. Nevertheless, considerable number did not show high efficiency, rendering existing data rather conflicting. above may be ascribed fact there heterogeneity amongst concerning dosage, administration duration, combination administration, method designs protocols, study populations. Although seems promising, it highly recommended accomplish larger, long-term, randomized, double-blind, controlled trials prospective design order derive conclusive results whether omega-fatty could act agent or even protective factors against Drug strategies developed novel synthetic analogs, which tested attenuate

Language: Английский

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Critical Appraisal of Systematic Reviews Assessing Gut Microbiota and Effect of Probiotic Supplementation in Children with ASD—An Umbrella Review

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 545 - 545

Published: Feb. 27, 2025

Given the significance of gut microbiota in autism spectrum disorder (ASD), we aimed to assess quality systematic reviews (SRs) studies assessing and effects probiotic supplementation children with ASD. PubMed, EMBASE, PsycINFO, Medline, Cochrane databases were searched from inception November 2024. We included SRs randomised or non-randomized reporting on probiotics A total 48 (probiotics: 21, microbiota: 27) included. The median (IQR) number participants was 7 (5) 328 (362), respectively, for intervention 18 (18) 1083 (1201), low 12, 14) critically 9, 13) due lack critical items including prior registration, deviation protocol, risk bias assessment studies. Assuring robust methodology future is important generating evidence this field.

Language: Английский

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Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2759 - 2759

Published: March 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Language: Английский

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Disruption in the human microbiome causing behavioural changes in bipolar disorder

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 2: Comorbidities

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1487 - 1487

Published: April 28, 2025

Pediatric obesity is associated with a wide range of comorbidities beyond metabolic changes, affecting cardiovascular, endocrine, reproductive, musculoskeletal systems, and also mental health. Hypertension, commonly observed in children obesity, increases the risk long-term cardiovascular disease. Polycystic ovary syndrome (PCOS) presents another significant endo-reproductive challenge that often develops during adolescence females, leading to further adulthood. Additionally, excess adiposity can negatively impact bone health by modifying metabolism increasing fracture risk. Obesity strongly linked disorders, including depression, anxiety, low self-esteem, which exacerbate unhealthy lifestyle behaviors disorders. Given limitations poor adherence traditional treatment strategies, nutraceuticals have emerged as potential complementary therapies due their bioactive properties. Various compounds demonstrated antihypertensive, insulin-sensitizing, anti-inflammatory effects, while others support promote well-being. Herewith, we discuss role managing hypertension, PCOS, health, issues individuals evaluating mechanisms action clinical relevance. Integrating nutraceutical dietary interventions may improve outcomes prevent obesity-related comorbidities. Further, emphasize need for large-scale studies, especially pediatric patients.

Language: Английский

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Antipsychotics and dietary interventions: pharmacodynamics, pharmacokinetics and synergisms in therapy

Pharmacological Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 100061 - 100061

Published: April 1, 2025

Language: Английский

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Autism Assessment in Iraqi children with Nutritional Supplements for Developing Social and Communication Skills: Parents' Views on Health Behavior

American Journal of Health Behavior, Journal Year: 2024, Volume and Issue: 48(2), P. 195 - 206

Published: April 30, 2024

Objective: This study aimed to know the impact of autism in Iraqi children by conducting a cross-sectional during 2020-2021, where 110 cases autistic were collected and distributed into two groups: 10 control 100 patient cases. Moreover, this also demonstrated importance health behavior for these children. Methodology: The demographic information data from Baghdad Hospitals over one year. used scales (CARS & Vineland 3) monitor with spectrum disorder (ASD) cover both adaptive skills intellectual skills, as many ASD may have an associated disability. Results: statistical analysis program "IBM SPSS)" was find out mean ages SDs, which 6.5 ± 1.6 group. As group, SDs (6.3 1.8). According first questionnaire, psychological state patients evaluated on CARS scale, low levels found all evaluation items, total score 45.8 6.09 / 60 diagnosis severe autism. same applies there no statistically significant differences between groups. Total 48 5.9 Conclusion: Patients groups according Scale 3. In groups, they did not achieve required score, scores found, patients' group 165.65 68.9, while 107 65.4. research that is factor their improvement.

Language: Английский

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Treating Cognition in Schizophrenia: A Whole Lifespan Perspective

Healthcare, Journal Year: 2024, Volume and Issue: 12(21), P. 2196 - 2196

Published: Nov. 4, 2024

Background/Objectives: Cognitive impairment is a core feature of schizophrenia, affecting attention, memory, and executive function contributing significantly to the burden disorder. These deficits often begin before onset psychotic symptoms persist throughout life, making their treatment essential for improving outcomes functionality. This work aims explore impact these impairments at different life stages interventions that have been developed mitigate effects. Methods: narrative review examined literature searching approaches treat cognitive in schizophrenia across lifespan. Results: alterations appear psychosis onset, suggesting window primary prevention. Then, period relative stability with slight decline gives secondary eventually tertiary prevention more than two decades. Finally, another occurs from third decade illness until later illness, when progression could be accelerated some cases. remediation physical exercise are evidence-based should provided all patients disabilities. Conclusions: Treating cognition whole lifespan crucial functional outcomes. It necessary consider need personalized, stage-specific strategies enhance functioning patients.

Language: Английский

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Development of an anti-inflammatory diet for first-episode psychosis (FEP): a feasibility study protocol

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 26, 2024

Evidence suggests inflammation plays a role in the pathophysiology of psychosis even early illness, indicating potential avenue for anti-inflammatory interventions that simultaneously address high rates metabolic disease this population. The aim study is to design novel diet intervention (DI) feasible implement first-episode (FEP)

Language: Английский

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