Isolation of circulating tumor cells: recent progress and future perspectives DOI Creative Commons
Z. H. Guo, Weiliang Xia

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 24, 2024

Abstract Circulating tumor cells (CTCs) are cancer that shed from the primary and enter into body fluids of patient, where they travel to distant sites ultimately form metastasis. Understanding biology CTCs, in particular at critical stages their itinerary, holds promises for better cure. Since beginning this century, liquid biopsy has steadily grown be a keen area research due its non-invasive features. As one most promising biomarkers, CTCs have shown great potential diagnosis, prognosis, treatment response monitoring, exploration biological mechanisms. Although various types isolation detection technologies emerge constantly, rarity heterogeneity still pose huge challenges these methods make them inefficient. In addition, clinical practice different lacks reasonable uniform standards. review, we provide detailed overview enrichment strategies as well advantages limitations. By summarizing current status suggesting future areas research, hope continue concerted effort pushing forward application which may represent paradigm shift theranostics future. Graphical

Language: Английский

Circulating Tumor Cells and DNA in Early Diagnosis and Prognosis of Metastatic Cancer DOI Creative Commons

Marium Jahan,

A. Rubab, Mohsin Ali

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Metastatic cancer remains a major challenge in oncology, often diagnosed late with limited intervention options. This chapter highlights the role of circulating tumor cells (CTCs) and DNA (ctDNA) as biomarkers for early detection, diagnosis, prognosis. Liquid biopsy, non-invasive method, analyzes blood components like CTCs, which provide insights into heterogeneity metastatic potential, ctDNA, reflects genetic mutations burden. These enable real-time monitoring, aiding understanding progression, treatment response, residual disease, resistance mechanisms. Advances detection methods emphasize their clinical relevance personalized treatment. Integrating CTCs ctDNA oncology could revolutionize management through individualized strategies, enhancing outcomes. The concludes challenges future directions implementing these precision oncology.

Language: Английский

Citations

1
Decoding the Role of Insulin-like Growth Factor 1 and Its Isoforms in Breast Cancer DOI Open Access

Amalia Kotsifaki,

Sousanna Maroulaki,

Efthymios Karalexis

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9302 - 9302

Published: Aug. 27, 2024

Insulin-like Growth Factor-1 (IGF-1) is a crucial mitogenic factor with important functions in the mammary gland, mainly through its interaction IGF-1 receptor (IGF-1R). This activates complex signaling network that promotes cell proliferation, epithelial to mesenchymal transition (EMT) and inhibits apoptosis. Despite extensive research, precise molecular pathways intracellular mechanisms activated by IGF-1, cancer, remain poorly understood. Recent evidence highlights essential roles of isoforms breast cancer (BC) development, progression, metastasis. The peptides define isoforms—IGF-1Ea, IGF-1Eb, IGF-1Ec—act as key points convergence for various influence growth, metastasis survival BC cells. aim this review provide detailed exami-nation role mature biology their potential use possible therapeutical targets.

Language: Английский

Citations

4
Application of Flow Cytometry in the Development of New Alternative Model Systems in Biomedical Research DOI
Anuj Kumar Pandey, Manish Raj Kulshrestha, Mukul Kumar Singh

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Breast Cancer Prognostic Model Based on Folic Acid Metabolism-Related Genes to Reveal the Immune Landscape DOI
Lin Lv, Xiaotao Zhu, Cong Jin

et al.

Hormone and Metabolic Research, Journal Year: 2025, Volume and Issue: 57(04), P. 262 - 272

Published: April 1, 2025

Abstract Breast cancer (BC) threatens women’s health, and the prognosis is dismal. Folic acid metabolism affects prognosis, but research on folic metabolism-related genes (FMRs) in BC scarce. We used TCGA-BRCA as training set GSE21653 validation set. Five FMRs (PLAT, SERPINA3, IFNG, SLC19A1, NFKB2) were screened via univariate LASSO Cox regression analyses, a prognostic model was built based multivariate analysis. The showed excellent predictive performance. Differentially expressed high- low-risk groups enriched steroid hormone biosynthesis neuroactive ligand-receptor interaction pathways. group exhibited higher immune cell infiltration better immunotherapy response. AM-5992 5-fluorodeoxyuridine 10mer may be potential drugs. This FMR-based can accurately predict offering clinical reference.

Language: Английский

Citations

0
Prognostic Value of the Number of Circulating Tumor Cells in Patients with Metastatic Non-Small Cell Lung Cancer DOI Creative Commons

Arthur B. Volovetsky,

В. А. Новикова,

Anastasia Boloban

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(4), P. 470 - 470

Published: April 15, 2025

Investigating the molecular and genetic characteristics of circulating tumor cells (CTCs) presents a promising approach for personalizing treatment in patients with malignant neoplasms, given limitations traditional biopsy histopathology. This study aimed to isolate, characterize, analyze CTC dynamics peripheral blood 30 metastatic lung cancer develop criteria response prognosis. We detected CTCs before start monitored changes during treatment, correlating these responses evaluated by standard imaging methods. A decrease course therapy was linked favorable response, while stable counts indicated lack poor survival The OS analyzed compared initial number samples. significant reductions median were evident >3 total at baseline those ≤3 (median 26 months, n = 10, vs. 8 19, respectively HR 2.6, 95% CI 1.07 6.4).

Language: Английский

Citations

0
Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review DOI

VEENA V. TOM,

A. De la Fuente Hernández José, Sumit Mallick

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Enhancing detection and monitoring of circulating tumor cells: Integrative approaches in liquid biopsy advances DOI Creative Commons

Thanmayi Velpula,

Buddolla Viswanath

The Journal of Liquid Biopsy, Journal Year: 2025, Volume and Issue: 8, P. 100297 - 100297

Published: April 29, 2025

Language: Английский

Citations

0
Isolation of circulating tumor cells: recent progress and future perspectives DOI Creative Commons
Z. H. Guo, Weiliang Xia

Med-X, Journal Year: 2024, Volume and Issue: 2(1)

Published: Dec. 24, 2024

Abstract Circulating tumor cells (CTCs) are cancer that shed from the primary and enter into body fluids of patient, where they travel to distant sites ultimately form metastasis. Understanding biology CTCs, in particular at critical stages their itinerary, holds promises for better cure. Since beginning this century, liquid biopsy has steadily grown be a keen area research due its non-invasive features. As one most promising biomarkers, CTCs have shown great potential diagnosis, prognosis, treatment response monitoring, exploration biological mechanisms. Although various types isolation detection technologies emerge constantly, rarity heterogeneity still pose huge challenges these methods make them inefficient. In addition, clinical practice different lacks reasonable uniform standards. review, we provide detailed overview enrichment strategies as well advantages limitations. By summarizing current status suggesting future areas research, hope continue concerted effort pushing forward application which may represent paradigm shift theranostics future. Graphical

Language: Английский

Citations

0