The Activation of the NF-κB Pathway in Human Adipose-Derived Stem Cells Alters the Deposition of Epigenetic Marks on H3K27 and Is Modulated by Fish Oil DOI Creative Commons
Jussara de Jesus Simão, Andressa França de Sousa Bispo, Victor Tadeu Gonçalves Plata

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1653 - 1653

Published: Dec. 12, 2024

Background: Chronic low-grade inflammation in obesity is linked to white adipose tissue (WAT) dysfunction. Plasma lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), triggering NF-κB and worsening these disturbances. Previously, we showed that histone H3 lysine 27 (H3K27) epigenetic modifications affect WAT gene expression high-fat-diet mice, identifying key pathways adipose-derived stem cells (ASCs). This study explores whether influences H3K27 modifiers human ASCs evaluates fish oil (FO) as a modulator. Methods: Human visceral were stimulated with LPS treated FO enriched eicosapentaenoic acid (EPA). Flow cytometry, PCR array, RT-PCR, Western blot assays used. Results: increased activity, elevating KDM6B demethylase levels acetylation. These LPS-stimulated associated persistent changes the of genes involved adipogenesis, metabolic regulation, inflammation, even after removal cell differentiation. mitigated effects, reducing acetylation promoting methylation. Conclusions: demonstrates potential modulating inflammation-induced preserving adipocyte function.

Language: Английский

Assessing the causal effect of genetically predicted metabolites and metabolic pathways on vitiligo: Evidence from Mendelian randomization and animal experiments DOI
Guanglu Li,

Baoquan Qu,

Tao Zheng

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: 247, P. 106677 - 106677

Published: Jan. 14, 2025

Language: Английский

Citations

1

Energy and Macronutrient Dietary Intakes of Serbian Adults 18–64 Years Old: EFSA EU Menu Food Consumption Survey in Serbia (2017–2022) DOI Creative Commons
Jelena Milešević, Milica Zeković, Ivana Šarac

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1228 - 1228

Published: March 31, 2025

This study offers a comprehensive analysis of the anthropometric and nutritional status among Serbian adults aged 18-64 years, using data from EFSA EU Menu food consumption survey conducted between 2017 2022. Based on nationally representative sample 1139 participants, this research utilized validated 24 h dietary recalls measurements. The results indicate significant imbalances, characterized by heavy reliance energy-dense foods, such as grains, fats, meat, with an underrepresentation fruits, vegetables, dairy. Men exhibited higher total energy intake, obtaining more meat while women consumed fruits vegetables but often did not meet recommended protein intake. Approximately 67.8% participants had insufficient fiber 15.4% recommendations, particularly women. Anthropometric measurements showed high prevalence overweight obesity, especially men. These findings highlight critical deficits in adequacy and, clinical practice perspective, underscore necessity for formulation policies, targeted public health strategies aimed at improving habits, provide evidence development national guidelines to support preventive healthcare strategies, management diet-related conditions, obesity metabolic disorders.

Language: Английский

Citations

1

Omega-3 and Sports: Focus on Inflammation DOI Creative Commons
Roberto Cannataro, Diana Marisol Abrego-Guandique,

Natascia Straface

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1315 - 1315

Published: Oct. 16, 2024

Inflammation is expected in sports, especially when practiced at a high level. The human body pushed toward its limit, and this perceived as “stressogenic agent”. Athletes, elite ones, desire it because their bodies can react with super-compensation, i.e., improve muscle mass, strength, speed, resistance, and, therefore, athletic performance. Thus, the inflammatory stimuli should be there during training but also counteracted to have placed optimal conditions for reacting super-compensation. In sense, omega-3 fatty acids been shown anti-inflammatory biochemical activity. review, we will present mechanisms of action through mediators, specialized pro-resolving which A focus on studies acid supplementation provide indications possible practical applications future studies, are undoubtedly necessary clarify used sports practice.

Language: Английский

Citations

4

Impact of Wall Material Composition (Maltodextrin vs. Inulin vs. Nutriose) and Emulsion Preparation System (Nano- vs. Microemulsion) on Properties of Spray-Dried Linseed Oil DOI Creative Commons
Dorota Ogrodowska, Iwona Konopka, Grzegorz Dąbrowski

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 171 - 171

Published: Jan. 4, 2025

The aim of this study was to compare the functional properties linseed oil powders made three types wall material (OSA starch + maltodextrin, OSA nutriose, and inulin) two emulsion phases (micro- nanoemulsion). For these independent variables, prepared emulsions (flow curves viscosity) resulting (encapsulation efficiency, particle size distribution, water activity, bulk tapped density, Carr’s index, color parameters, thermal stability) were determined. results showed that viscosity most powder affected by type. All demonstrated Newtonian-like behavior, with values ranging from 29.07 48.26 mPa·s. addition nutriose induced significant variation in parameter, nanoemulsification leading a 1.6-fold increase compared microemulsification. application prepare prior spray-drying resulted lower surface content (by 78.8–88.5%), density 1.7–14.2%), index 7.6–14.0%), as well higher encapsulation efficiency 5.9–17.0%). decreased oxidative stability 30.9–51.1%) obtained nanoemulsified related 4.7–15.9-fold content. Powders produced using inulin had smallest uniform sizes, showing minimal between derived nano- microemulsified emulsions.

Language: Английский

Citations

0

Effect of Organic Farming Techniques on the Quality of Almond Fat DOI Creative Commons
María Dolores García-Martínez, Patricia Esteve Ciudad,

Miguel Ángel Gómez Tenorio

et al.

Horticulturae, Journal Year: 2025, Volume and Issue: 11(2), P. 135 - 135

Published: Jan. 27, 2025

Almond fruit is characterized by a mature, hardened endocarp enclosing the seed. Despite being drupe botanically, almonds are commonly referred to as nuts due their low water content. The edible seed, known kernel, primary commercial product. Fatty acid composition was determined value quality of fat over four years in Guara variety, from plots where production system (organic and conventional), irrigation (intense irrigation, support dry land), use plant cover varied. oil content fatty were using different sustainable agriculture techniques. Oil almond ranged 35% 55% total fresh weight with strong variability between years. also highly variable, significant differences depending on agricultural practices. Oleic acid, which 59% 78%, statistically higher irrigation. Plant favored synthesis oleic acid. Linoleic 11% 25%, had organic farming land conditions. atherogenic thrombogenic indices health-beneficial better organically prod\uced almonds. great observed represents very promising basis for establishing practices adaptation arid cultivation conditions, management, regenerative techniques, satisfying requirements healthier more diets.

Language: Английский

Citations

0

Energy and Macronutrient Dietary Intakes of Vegetarian and Semi-Vegetarian Serbian Adults: Data from the EFSA EU Menu Food Consumption Survey (2017–2022) DOI Creative Commons
Ivana Šarac, Jelena Milešević, Marija Knez

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1285 - 1285

Published: April 8, 2025

This study is the first to examine diet and nutritional status of adult vegetarian semi-vegetarian population in Serbia, using data from EFSA EU Menu Food Consumption Survey 2017–2022. The survey included 314 participants (63 vegans, 192 lacto-ovo vegetarians, 50 pescatarians, 9 flexitarians), aged 18–74 years (166 women 148 men, with no gender differences dietary patterns) across all regions Serbia. Collected anthropometrics (BMI) intake energy, macronutrients, specific food groups (assessed through two 24 h recalls). revealed multiple shortcomings three patterns. most significant was an insufficient protein (especially among but also non-vegans), connected unsatisfactory quantity, quality, availability plant sources. There a high fat (particularly omega-6 trans-fats-rich sources), especially non-vegans (but vegans), while omega-3 sources low. Non-vegans consumed less carbohydrates, fiber, vegetables, fruit, more sweets, beverages, alcohol. Our findings highlight need for improved education vegetarians/semi-vegetarians Serbia development national system-based guidelines this population.

Language: Английский

Citations

0

Neem Oil: A Comprehensive Analysis of Quality and Identity Parameters DOI Open Access
Vitor Emanuel de Souza Gomes,

Paula Fernanda Janetti Bócoli,

Julia Guirardello Iamarino

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2), P. 9 - 9

Published: May 7, 2025

Background: Neem seed oil (Azadirachta indica A. Juss) is widely used in the pharmaceutical, agricultural, and food industries due to its antiseptic, fungicidal, pesticidal, antioxidant properties, attributed over 300 bioactive compounds a high content of unsaturated fatty acids. Methods: This study aimed characterize commercial sample neem regarding physicochemical properties identity profile, using official methodologies from American Oil Chemists’ Society (AOCS), compare results with literature data. Results: The exhibited following parameters: free acids (2.0 ± 0.02%), acidity index (3.9 0.04 mg KOH/g), peroxide value (3.2 0.1 mEq/kg), iodine (116 12 g I2/100 g), saponification (198 8 KOH/g). predominant coloration was yellowish, total chlorophyll carotenoid levels below equipment’s quantification limits. Fatty acid composition mainly long-chain (C16–C18), notable linoleic (46%), oleic (28%), palmitic (12%), linolenic (5.5%), stearic (4.1%). triacylglycerol profile showed predominance triunsaturated (51%) diunsaturated species (41%). Differential scanning calorimetry (DSC) analysis revealed crystallization events between −6 °C −57 fusion −44 −1 °C, consistent unsaturation level lipids. Conclusions: analyzed meets quality criteria, making it suitable for various industrial applications. characterization confirms potential aligns data, emphasizing relevance use.

Language: Английский

Citations

0

Molecular Mechanism of Phytochemical Compounds in Mitigating Hypertension DOI Creative Commons
Putri Cahaya Situmorang, Syahputra Wibowo,

Masitta Tanjung

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100812 - 100812

Published: May 1, 2025

Language: Английский

Citations

0

Fish Oil Containing Pro-Resolving Mediators Enhances the Antioxidant System and Ameliorates LPS-Induced Inflammation in Human Bronchial Epithelial Cells DOI Creative Commons
Alfio Distefano, Laura Orlando, Sebastiano Giallongo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1066 - 1066

Published: Aug. 14, 2024

Fish oil, renowned for its high content of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), has gained considerable attention potential health benefits. EPA DHA exhibit anti-inflammatory effects by promoting the production specialized pro-resolving mediators (SPMs), such as resolvins protectins. oil been studied to reduce bronchial inflammation, a key feature respiratory conditions like asthma COPD. This study investigates cellular mechanisms fish in an vitro model lung inflammation using lipopolysaccharide (LPS) on healthy human epithelium cell line. LPS exposure 24 h reduced viability, elevated reactive oxygen species (ROS), depleted glutathione (GSH), induced mitochondrial depolarization, indicating oxidative stress inflammation. administration significantly mitigated ROS production, prevented GSH depletion, depolarization. was associated with upregulation endogenous antioxidant system, evidenced restored levels increased gene expression peroxidase (GPX), catalase (CAT), superoxide dismutase 1 (SOD1), 2 (SOD2). also suppressed IL-6 IL-1β cytokine IL-10 expression. Furthermore, upregulated mediator receptors, suggesting role resolution. These findings highlight supplementation preventive measure against pulmonary diseases characterized unresolved

Language: Английский

Citations

0

Metabolic Effects of Loquat Juice (Eriobotrya japonica Lindl Mkarkeb Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat–High-Fructose Diet DOI Creative Commons
Imane Mokhtari, Thamer Aljutaily, Huda Aljumayi

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 592 - 592

Published: Nov. 2, 2024

Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, carotenoids. This study aimed at the biochemical characterization fresh juice from Moroccan

Language: Английский

Citations

0