Gut Microbiota, Bacterial Translocation, and Stroke: Current Knowledge and Future Directions DOI Creative Commons
Cristina Granados-Martinez, Nuria Alfageme-Lopez, Manuel Navarro-Oviedo

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2781 - 2781

Published: Dec. 6, 2024

Stroke is one of the most devastating pathologies in terms mortality, cause dementia, major adult disability, and socioeconomic burden worldwide. Despite its severity, treatment options remain limited, with no pharmacological therapies available for hemorrhagic stroke (HS) only fibrinolytic therapy or mechanical thrombectomy ischemic (IS). In pathophysiology stroke, after acute phase, many patients develop systemic immunosuppression, which, combined neurological dysfunction hospital management, leads to onset stroke-associated infections (SAIs). These worsen prognosis increase mortality. Recent evidence, particularly from experimental studies, has highlighted alterations microbiota–gut–brain axis (MGBA) following which ultimately disrupts gut flora increases intestinal permeability. changes can result bacterial translocation (BT) sterile organs, further contributing development SAIs. Given novelty significance these processes, especially role BT SAIs, this review summarizes latest advances understanding phenomena discusses potential therapeutic strategies mitigate them, reducing post-stroke complications improving outcomes.

Language: Английский

The Microbial Perspective: A Systematic Literature Review on Hypertension and Gut Microbiota DOI Open Access

Alexandros Tsiavos,

Christina Antza, Christina Trakatelli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3698 - 3698

Published: Oct. 30, 2024

Background: Understanding the causes of hypertension is important in order to prevent disease. Gut microbiota (GM) seems play an role, but detailed physiology remains elusive, with alpha diversity being most studied indicator. Objectives: This review aimed systematically synthesize data on gut (alpha diversity) and hypertension. Methods: Databases, including MEDLINE/PubMed, Scopus, EMBASE, citations were queried. We retrieved articles reporting association between A valid critical appraisal tool was also used investigate quality included studies. Results: Eighteen eligible studies met our inclusion criteria. In this report, we focused following indices diversity: Shannon, Chao1, Simpson, Abundance-based Coverage Estimator (ACE) indices. Several observed a significantly lower Shannon index hypertensive patients compared healthy control group. Nevertheless, no statistically significant difference found for ACE controls. higher Firmicutes-to-Bacteroidetes ratio (F/B ratio) consistently controls, indicating potential dysbiosis microbiota. Conclusions: Our systematic indicates that may exhibit imbalance microbiota, evidenced by decreased elevated F/B ratio. However, absence differences secondary (Chao1, ACE) highlights need further research. Well-designed, large-scale are necessary clarify these associations explore role development.

Language: Английский

Citations

4
Impact of lifestyle factors post-infectious mononucleosis on multiple sclerosis risk DOI Creative Commons

Eva Johansson,

Tomas Olsson, Lars Alfredsson

et al.

European Journal of Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Accumulating evidence suggest that Epstein-Barr virus (EBV) is crucial in the development of multiple sclerosis (MS), with inadequate infection control possibly contributing to disease onset. Past infectious mononucleosis (IM) has been found interact smoking, obesity, and sun exposure. We aimed investigate potential interactions between a history IM following risk factors for MS: passive alcohol consumption, fish vitamin D status, adolescent sleep duration quality. analyzed data from Swedish population-based case-control study (3128 cases 5986 controls). Subjects were categorized based on status each exposure variable compared regarding MS by calculating odds ratios (OR) 95% confidence intervals (CI) using logistic regression models. Additive interaction aspects was assessed attributable proportion due (AP) CI. The OR developing among those who reported 1.86 (95% CI 1.63-2.12), had not suffered IM. observed synergistic effects respect MS, significant APs ranging 0.20 0.35. concept EBV as factor gains further support our findings suggesting synergize development. Targeting modifiable impede effective immune regulation holds promise preventive interventions.

Language: Английский

Citations

0
Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota DOI
Xiang Li, Xiaojun Wang,

Linping Zhu

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Dietary intake in healthy older individuals is associated with lipopolysaccharide binding protein a biomarker of gut function: an exploratory cross-sectional study DOI Creative Commons
Debra Jones, Douglas J. Morrison, Stuart R. Gray

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 31, 2025

Diet, physical function and gut health are important modifiable factors in ageing. However, it is unclear how ageing affects various domains of function. Aims this cross-sectional study were to explore relationships between nutrient intake, function, biomarkers older individuals. Healthy participants (n = 94, mean age 71.1 years SD 5.10, 56% female) recruited investigate the relationship intake (protein, fibre, carbohydrate, fat), (chair rise time, handgrip strength) lipopolysaccharide (LPS) binding protein (LBP); a marker permeability. Linear regression models, adjusted for age, fat mass/fat free mass ratio, weight gender, reported LBP changed by; -161.9 ng/mL (95% CI -323.0, -0.8) every 1 g increase daily fibre/1,000 kilocalories; 80.5 (6.7, 154.2) 1% energy as fat; -88.1 (-146.7, -29.6) carbohydrates. When further C-reactive (CRP), inflammation, decreased by an additional 6.9 increased 4.0 3.7 carbohydrate. These findings suggest that healthy adults' associated with LBP, CRP appears slightly modify these associations. There no associations strength or chair time. Results fat, carbohydrates maintaining potentially mediated inflammation adults, although research needed implications mediator.

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0
“Gut Microbiota as a Therapeutic Target for Hypertension: Challenges and Insights for Future Clinical Applications” “Gut Microbiota and Hypertension Therapy” DOI
Elsayed M. Mahgoup

Current Hypertension Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 22, 2025

Language: Английский

Citations

0
Gut Microbiota, Bacterial Translocation, and Stroke: Current Knowledge and Future Directions DOI Creative Commons
Cristina Granados-Martinez, Nuria Alfageme-Lopez, Manuel Navarro-Oviedo

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2781 - 2781

Published: Dec. 6, 2024

Stroke is one of the most devastating pathologies in terms mortality, cause dementia, major adult disability, and socioeconomic burden worldwide. Despite its severity, treatment options remain limited, with no pharmacological therapies available for hemorrhagic stroke (HS) only fibrinolytic therapy or mechanical thrombectomy ischemic (IS). In pathophysiology stroke, after acute phase, many patients develop systemic immunosuppression, which, combined neurological dysfunction hospital management, leads to onset stroke-associated infections (SAIs). These worsen prognosis increase mortality. Recent evidence, particularly from experimental studies, has highlighted alterations microbiota–gut–brain axis (MGBA) following which ultimately disrupts gut flora increases intestinal permeability. changes can result bacterial translocation (BT) sterile organs, further contributing development SAIs. Given novelty significance these processes, especially role BT SAIs, this review summarizes latest advances understanding phenomena discusses potential therapeutic strategies mitigate them, reducing post-stroke complications improving outcomes.

Language: Английский

Citations

1