Investigation of β-Carboline Alkaloid Harmaline Against Cyvirus cyprinidallo3 Infection In Vitro and In Vivo

Viruses, Journal Year: 2025, Volume and Issue: 17(5), P. 687 - 687

Published: May 9, 2025

Cyvirus cyprinidallo3, also known as Cyprinid herpesvirus 3 (CyHV-3), is a common pathogen of koi and carp (Cyprinus carpio). Infection CyHV-3 can lead to high mortality in fry under 4 months age. become latent recovered fish, reactivate stress conditions spread the virus. Reactivation diseases latently infected fish. No effective drugs are available prevent infection or reactivation from latency. There need for discovery anti-CyHV-3 drugs. Harmine (HAR) harmaline (HAL) β-carboline alkaloids found medicinal plant Peganum harmala with antiviral activities against many viruses, including HSV. Here, HAL was evaluated vitro vivo, respectively. Immediately after one-hour exposure ~1000 FPU/plate ~500 PFU/plate, cells treated 5 µM 2 h block nearly 50% 90% plaque formation vitro. Only around inhibition observed anti-herpesvirus drug acyclovir (ACV) at 10 20 following 1 post-infection PFU/plate. Cells 30 min, 60 h, 6 reduce 60%, 65%, 85.5%, 85% replication vitro, still DNA virion production when treatment started days 50 has little toxicity 24 h. Immersion 3–4 daily within first increase survival by 60%. In addition, IM injection rate induced heat koi. This study demonstrated that could potentially be used

Language: Английский

Interaction of normelinonine F and related N-methyl-β-carbolines derivatives with bovine serum albumin. Spectroscopic profiles, multivariate analysis and theoretical calculations

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140136 - 140136

Published: Jan. 1, 2025

Language: Английский

Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3569 - 3569

Published: July 29, 2024

In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone

Language: Английский