Circulating micronutrients levels and their association with the risk of endometriosis DOI Creative Commons

Yanna Zhang,

Meng Li, Feifei Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 16, 2024

Background Endometriosis, a prevalent gynecological disease, has an unclear pathogenesis. Micronutrients play crucial role in disease development, which led to investigation of their association with endometriosis. Methods In this study, we analyzed the relationship between 15 micronutrients and endometriosis using both univariate multivariate Mendelian randomization (MR) assess correlation. The results were validated high-performance liquid chromatography (HPLC). Results MR analysis indicated that vitamin B6 (OR = 1.7060, 95% CI: 1.1796–2.4672, p 0.0045) calcium 1.4834, 1.0747–2.0475, 0.0165) are associated increased risk Higher intakes greater likelihood developing Egger regression’s intercept term demonstrated no evidence pleiotropy ( > 0.05) or heterogeneity (p SNPs for B6. analysis, 2.397, 1.231–4.669, 0.01) was linked endometriosis, independently other exposure factors. No significant 0.831) 0.369) observed genetic variation affirming reliability analysis. HPLC confirmed increase serum levels calcium, aligning findings. Conclusion Vitamin may be potentially acting as independent factor. Further research is essential elucidate offering novel insights prevention treatment strategies.

Language: Английский

Study of Toxic and Essential Elemental Imbalances at More Advance Stage of Breast Carcinoma Patients DOI
Muhammad Abdul Qayyum, Sajid Mahmood,

Ali Bahadur

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155866 - 155866

Published: Feb. 27, 2025

Language: Английский

Citations

0
El Estilo de Vida como un Factor de Riesgo para el Desarrollo del Cáncer de Mama en Mujeres DOI Creative Commons

M. Navarro,

L. García,

Blanca Margarita García-Donjuán

et al.

Estudios y Perspectivas Revista Científica y Académica, Journal Year: 2025, Volume and Issue: 5(1), P. 1864 - 1877

Published: March 7, 2025

El cáncer de mama es la neoplasia invasiva más común y primera causa muerte por en mujeres a nivel mundial. Para el inicio progresión del se han asociado diversos factores riesgo, entre ellos los modificables no modificables. Dentro riesgo encuentra estilo vida, que define como forma general basada interacción las condiciones vida un sentido amplio patrones individuales conducta determinados socioculturales características personales. Este estudio tiene propósito establecer relación existe desarrollo mama. La metodología seguida fue búsqueda artículos relacionados con plataformas Pubmed, Google scholar, páginas oficiales gubernamentales. Nuestros resultados arrojaron una hábitos alcoholismo, tabaquismo, sedentarismo dieta predispone obesidad

Citations

0
Association between exposure to heavy metals and the risk of breast cancer: A case-control study in Tanzania DOI

Emmanuel Njale,

John A.M. Mahugija,

Dativa J. Shilla

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 110, P. 104498 - 104498

Published: July 24, 2024

Language: Английский

Citations

2
Breast cancer burden among young women from 1990 to 2021: a global, regional, and national perspective DOI

Zhuojun Tang,

Yiying Wei,

Yanqing Liang

et al.

European Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Background Breast cancer, the most prevalent tumor in women globally, significantly impacts young women, compromising their daily lives and overall well-being. cancer represents a significant public health concern due to its extensive physical psychological consequences. Material methods Data from Global Burden of Disease (GBD) were used assess global, regional, national burden breast aged 20–39 1990 2021. This analysis focused on trends measured by estimated annual percentage change (EAPC) explored socioeconomic via sociodemographic index (SDI). Results During 1990–2021, incidence prevalence among increased with rates 0.82 0.87%, respectively. The mortality rate disability-adjusted life years (DALYs) also rose annually −0.12% −0.05, A shift was observed towards regions lower SDI, diet high red meat, alcohol use, fasting plasma glucose identified as prominent risk factors, particularly SDI regions. Conclusion Our findings underscore an escalating global challenge, increasingly shifting areas. underscores necessity for targeted prevention control strategies focusing reducing factors ensuring equitable resource distribution.

Language: Английский

Citations

1
Methylation modification of non-histone proteins in breast cancer: An emerging targeted therapeutic strategy DOI Creative Commons
Mingyao Huang,

Zirong Jiang,

Yadan Xu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107354 - 107354

Published: Aug. 17, 2024

Breast cancer is a major public health concern worldwide, being the most commonly diagnosed among women and leading cause of cancer-related deaths. Recent studies have highlighted significance non-histone methylation in breast cancer, which modulates activity, interaction, localization, stability target proteins. This regulation affects critical processes such as oncogenesis, tumor growth, proliferation, invasion, migration, immune responses. review delves into enzymes responsible for methylation, protein arginine methyltransferases (PRMTs), lysine (KMTs), demethylases, explores their roles cancer. By elucidating molecular mechanisms functional consequences this aims to provide insights novel therapeutic strategies targeting these pathways. The potential overcome drug resistance enhance treatment efficacy also discussed, highlighting promising avenues future research clinical applications.

Language: Английский

Citations

0
Circulating micronutrients levels and their association with the risk of endometriosis DOI Creative Commons

Yanna Zhang,

Meng Li, Feifei Zhang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 16, 2024

Background Endometriosis, a prevalent gynecological disease, has an unclear pathogenesis. Micronutrients play crucial role in disease development, which led to investigation of their association with endometriosis. Methods In this study, we analyzed the relationship between 15 micronutrients and endometriosis using both univariate multivariate Mendelian randomization (MR) assess correlation. The results were validated high-performance liquid chromatography (HPLC). Results MR analysis indicated that vitamin B6 (OR = 1.7060, 95% CI: 1.1796–2.4672, p 0.0045) calcium 1.4834, 1.0747–2.0475, 0.0165) are associated increased risk Higher intakes greater likelihood developing Egger regression’s intercept term demonstrated no evidence pleiotropy ( > 0.05) or heterogeneity (p SNPs for B6. analysis, 2.397, 1.231–4.669, 0.01) was linked endometriosis, independently other exposure factors. No significant 0.831) 0.369) observed genetic variation affirming reliability analysis. HPLC confirmed increase serum levels calcium, aligning findings. Conclusion Vitamin may be potentially acting as independent factor. Further research is essential elucidate offering novel insights prevention treatment strategies.

Language: Английский

Citations

0