Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 801 - 824
Published: Nov. 11, 2024
Background. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation survival. Excessive stimulation, ill-function, or blockade GPCRs produces disturbances that may cause disease should compensatory mechanisms not suffice. Methods Results. Revision updated experimental research provided an evident relationship associating peptidergic malfunction with tumor formation maintenance resulting from uncontrolled proliferation migration, colonization, inhibition apoptosis altered metabolism, increased angiogenesis tumoral tissues. Conclusion. Determination implication peptide signaling specific neoplasia is crucial to designing tailored pharmacological treatments counteract dismantle origin circuitry causing cellular disruption. In some cases, particular ligands these receptors serve as concomitant aid other physical approaches eradicate neoplasias.
Language: Английский