Ukrainian Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
31(5), P. 7 - 20
Published: Oct. 30, 2024
The
aim
–
to
establish
markers
of
clinical
and
functional
state
development
in
patients
with
acute
myocardial
infarction
inherent
wartime.Materials
methods.
A
cohort
133
STEMI
was
examined
(77.4
%
men,
61.7±0.9
years).
Part
the
(group
1)
hospitalized
from
February
May
2019
(n=87),
while
other
part
them
2)
period
24,
2022
2023
(n=46)
within
first
24
hours
symptoms
(average
time
admission
5.2±0.4
hours).
In
order
eliminate
discrepancies
indicators,
which
a
low
probability
are
related
action
wartime
factors,
comparable
samples
were
made
groups
1
2
(52
17
patients,
respectively).
Comparison
carried
out
based
on
anamnestic
laboratory
parameters
day.Results
discussion.
At
hospital,
specific
due
influence
factors
are:
level
leukocytes
>
13.0
·
109/L,
monocytes
0.5
lymphocytes
1.2
.
triglycerides
1.63
mmol/L,
heart
rate
76
beats/min,
as
well
criteria
up
these
indicators
(in
particular,
products
or
lymphocytes,
rate,
7-component
scale,
takes
into
account
ESR,
glucose
triglyceride
levels,
number
monocytes,
platelets).
Moreover,
increase
is
not
associated
hospital
complications
patients.
Instead,
triglycerides,
platelets
directly
both
complicated
course
STEMI.Conclusions.
combined
response
damage.
It
leads
an
risk
stage,
changes.
These
changes
make
it
possible
recognize
impact
at
high
infarction.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
200, P. 106610 - 106610
Published: July 18, 2024
Chronic
stress
is
a
major
precursor
to
various
neuropsychiatric
disorders
and
linked
with
increased
inflammation
in
the
brain.
However,
bidirectional
association
between
chronic
has
yet
be
fully
understood.
Astrocytes
are
one
of
key
inflammatory
regulators
brain,
morphological
change
reactive
astrocytes
serves
as
an
important
indicator
inflammation.
In
this
study,
we
evaluated
sex-specific
astrocyte
response
or
systemic
brain
regions
associated
mood
disorders.
We
conducted
unpredictable
mild
(UCMS)
paradigm
model
stress,
lipopolysaccharide
(LPS)
injection
To
evaluate
stress-induced
changes
complexity,
measured
GFAP
fluorescent
intensity
for
expression,
branch
bifurcation
by
quantifying
points
terminal
points,
arborization
conducting
Sholl
analysis,
calculated
ramification
index.
Our
analysis
indicated
that
all
investigated.
The
effects
were
region
sex
specific.
Notably,
females
had
greater
inflammation-induced
activation
hypothalamus
(HYPO),
CA1,
CA3,
amygdala
(AMY)
than
males.
These
findings
indicate
induces
may
drive
region-specific
females,
potentially
contributing
sex-dependent
mechanisms
disease.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3844 - 3844
Published: April 18, 2025
Depression,
often
described
as
the
“silent
epidemic”
of
21st
century,
stands
a
complex
and
pervasive
mental
health
challenge
that
affects
millions
individuals
worldwide
[...]
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2539 - 2539
Published: Nov. 7, 2024
The
interplay
between
socio-psychological
factors
and
biological
systems
is
pivotal
in
defining
human
health
disease,
particularly
chronic
non-communicable
diseases.
Recent
advancements
psychoneuroimmunology
mitochondrial
psychobiology
have
emphasized
the
significance
of
psychological
as
critical
determinants
disease
onset,
progression,
recurrence,
severity.
These
insights
align
with
evolutionary
biology,
psychology,
psychiatry,
highlighting
inherent
social
nature
humans.
This
study
proposes
a
theory
that
expands
insulin's
role
beyond
traditional
metabolic
functions,
incorporating
it
into
Mitochondrial
Information
Processing
System
(MIPS)
exploring
from
an
medicine
perspective
to
explore
its
function
processing
responses.
narrative
review
comprises
data
preclinical
animal
studies,
longitudinal
cohort
cross-sectional
machine
learning
analyses,
randomized
controlled
trials,
investigates
insulin
disease.
result
proposal
for
theoretical
framework
substance
within
socio-psycho-biological
framework,
emphasizing
extensive
roles
Type
2
Diabetes
Mellitus
(T2DM)
musculoskeletal
disorders
neurodegeneration
exemplifies
this
narrative.
We
suggest
further
research
towards
comprehensive
treatment
protocol
meeting
expectations,
where
psychosocial
interventions
plays
essential
role.
By
supporting
concept
'insulin
resilience'
suggesting
use
heart
rate
variability
assess
resilience,
we
aim
provide
integrative
approach
managing
levels
monitoring
effectiveness
interventions.
strategy
addresses
broader
factors,
ultimately
improving
outcomes
individuals
T2DM
complications
while
providing
new
