Rod‐Shaped Microgel Scaffolds with Interconnective Pores and Oxygen‐generating Functions Promote Skin Wound Healing and Alleviate Hypertrophic Scar Formation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract The processes of skin wound healing and scar formation are complex, often involving hypoxia inflammation, which create a pathological microenvironment that impedes normal healing. Improving oxygenation reducing inflammation crucial for accelerating scarring. Traditional dressings like sponges, gauze, hydrogels struggle to balance moisture retention, breathability, exudate absorption. To address these challenges, rod‐shaped microgel scaffolds with larger surface areas interconnected porous structures explored enhance gas transport, promoting thus Nanoparticles (NPs) used mediate the microgels‐assembled scaffold load catalase (CAT) enhanced bioactivity. In vitro experiments showed this material alleviated oxidative stress reduced activity hypoxia‐inducible factor‐1α (HIF‐1α), nuclear factor kappa B (NF‐κB), downstream transforming growth factor‐β1 (TGF‐β)/Smad pathway in fibroblasts. incorporation CAT significant promotion M2‐phenotype macrophage polarization. vivo studies on rat rabbit wounds demonstrated significantly improved absorption maintaining moist oxygenated environment. These tissue hypoxia, accelerated healing, decreased hypertrophic vivo. This innovative method leveraged unique properties microgels effectively regeneration.

Language: Английский

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Porous Hydrogels from Nanoemulsion Templates With Different Structures

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Porous hydrogels, including physical pores and spaces within the polymer network, exhibit rapid water uptake rates. Synthesizing porous hydrogels through nanoemulsion templating represents a promising avenue for development of advanced materials with tailored properties. Certain attributes, but not limited to ability tune droplet size, volume fraction, interdroplet interactions, provide tools precisely manipulate structure nanoemulsions. The main research question is how colloidal template changes characteristics network. Therefore, this study investigates preparation using concentrated nanoemulsions as templates where modulating interactions results in different pore structures properties Nanoemulsions are prepared by dispersing oil droplets continuous phase containing poly (ethylene glycol)‐diacrylate (PEGDA) sodium dodecyl sulfate (SDS). Subsequent photo‐polymerization PEGDA removal leaves behind structure. Then, Hydrogels analyzed relationship between netwrok capacities. discussion focuses on arrangement under influence altered concentrations SDS, provides confinement changing crosslink density

Language: Английский

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Designing Stable Macroporous Hydrogels: Effects of Single and Dual Surfactant Systems on Porous Architecture, Absorption Capacity, and Mechanical Strength

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

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In Situ-Formed Tissue-Adhesive Macroporous Scaffolds Enhance Cell Infiltration and Tissue Regeneration

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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