The effects of obesity on thyroid function in a metabolically healthy high-fat, high-carbohydrate diet-induced obese rat model

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Obesity is a recognized exacerbator of thyroid dysfunction due to its detrimental effects on energy homeostasis, appetite regulation, basal metabolic rate, thermogenesis, and metabolism. However, almost all the reported findings obesity-related are based models metabolically unhealthy obesity (MUO) in presence insulin resistance. There currently no studies using healthy (MHO) model characterized by absence resistance investigate dysfunction. Hence, this study aimed association between high-fat high-carbohydrate diet-induced obese rat model. Male Sprague Dawley rats were randomly divided into either control diet or group (HFHC) (n=9, per group). During 5-month induction period, did not develop while consuming standard with water. The HFHC consumed water for same duration was diagnosed obesity. Post-obesity confirmation, animals continued respective diets further 7 months maintain state. Caloric intake, fasting blood glucose (FBG) BMI measured once month experiment. Glucose homeostasis functional parameters assessed terminally, accompanied satiety pro-inflammatory markers. presented higher BMI, caloric intake FBG, elevated insulin, HOMA-IR, Hb1Ac, leptin IL-6 levels compared group. significantly TSH, fT3 fT4. These observations suggest that disturbed glycemic status indicators concentrations satisfy minimum criteria be as MUO. has induced MHO male rats. This warrants homeostatic changes occur during can open new avenues developing preventative measures avoid progressing

Language: Английский

Monocyte-to-lymphocyte ratio in the early second trimester is a predictor of gestational diabetes mellitus

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2024, Volume and Issue: 37(1)

Published: Jan. 2, 2024

Objective To evaluate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), neutrophil-to-monocyte (NMR), and other hemogram-derived inflammatory parameters measured in the early second trimester their association with risk of gestational diabetes mellitus (GDM).

Language: Английский