Impact of COVID-19 on adverse reactions to subcutaneous specific immunotherapy in children:a retrospective cohort study DOI Creative Commons
Jingjing Li, Yanling Chen, Hong Ye

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 7, 2024

COVID-19 is a new infectious disease. To investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases the adverse reactions of subcutaneous specific immunotherapy (SCIT) in children. This study was conducted by collecting relevant data from children who underwent house dust mite SCIT April 3, 2021, to March 18, 2023, including information on time infection, symptoms, and after each allergen injection. A mixed effects model used analyze changes before infection. Among records 2658 injections 123 SCIT, overall reaction rate 39.8% 30.0% Compared with pre-infection COVID-19, risks reactions, local systemic were reduced (odds ratio [OR] = 0.24, 0.31, 0.28, all P < 0.05). incidence unvaccinated group highest (15.3% vs. 7.1%). The decreased 2-vaccinated recipients (OR 0.29–0.31, In children, SARS-CoV-2 does not increase SCIT. finding can provide basis for implementation allergen-specific (AIT) during pandemic.

Language: Английский

Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils DOI Creative Commons
Łukasz Suprewicz, Krzysztof Fiedoruk,

Karol Skłodowski

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 5, 2025

Language: Английский

Citations

1
Special Issue “The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0” DOI Open Access
Ralf Kircheis, Oliver Planz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9709 - 9709

Published: Sept. 7, 2024

Toll-like receptors (TLRs) are key players in the innate immune system, host’ first-line defense against pathogens [...]

Language: Английский

Citations

5
The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis DOI
Payam Behzadi, Deepak Chandran, Chiranjib Chakraborty

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137836 - 137836

Published: Nov. 1, 2024

Language: Английский

Citations

3
Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies DOI Creative Commons

Aliteia-Maria Pacnejer,

Anca Butucă, Carmen Maximiliana Dobrea

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1811 - 1811

Published: Nov. 21, 2024

The COVID-19 outbreak, caused by the SARS-CoV-2 virus, was linked to significant neurological and psychiatric manifestations. This review examines physiopathological mechanisms underlying these neuropsychiatric outcomes discusses current management strategies. Primarily a respiratory disease, frequently leads issues, including cephalalgia migraines, loss of sensory perception, cerebrovascular accidents, impairment such as encephalopathy. Lasting neuropsychological effects have also been recorded in individuals following infection. These include anxiety, depression, cognitive dysfunction, suggesting lasting impact on mental health. neuroinvasive potential inflammatory responses, role angiotensin-converting enzyme 2 (ACE2) neuroinflammation are critical factors In addition, highlights importance monitoring biomarkers assess Central Nervous System (CNS) involvement. Management strategies for conditions supportive therapy, antiepileptic drugs, antithrombotic psychotropic emphasizing need multidisciplinary approach. Understanding long-term implications is essential developing effective treatment protocols improving patient outcomes.

Language: Английский

Citations

1
ANÁLISE DA RELAÇÃO SINTOMA-SEQUELA COM VARIANTES DO VÍRUS SARS-COV-2 EM PACIENTES PORTADORES DE COVID LONGA: UMA REVISÃO DESCRITIVA DOI Creative Commons

Andréa Patrícia Marques da Silva,

Fabiana Kelly Roque da Silva,

Rejane Cleide do Nascimento

et al.

Revista Contemporânea, Journal Year: 2024, Volume and Issue: 4(7), P. e5271 - e5271

Published: July 31, 2024

A COVID longa refere-se aos sintomas persistentes após a infecção aguda pelo SARS-CoV-2, incluindo fadiga, dificuldade respiratória, perda de memória, dores musculares e articulares, olfato ou paladar, problemas cardíacos neurológicos, cuja gravidade pode variar entre os indivíduos. Desde o início da pandemia, surgiram várias variantes do como Alfa, Beta, Gama, Delta Ômicron, cada uma impactando forma diferente prevalência natureza das sequelas longa. fase é um fator crucial ser comparado com as em geral, embora variante tipo Delta, acordo estudos, parecem aumentar probabilidade internações hospitalares por COVID-19. Variantes maior transmissibilidade carga viral, elevam devido à novos tropismos evasão resposta imunológica. falta estudos sobre diante sua importância clínica, dificulta diagnóstico, tratamento, compreensão dos mecanismos subjacentes, avaliação impacto na saúde pública formação médica adequada. É necessário investir mais pesquisas para melhorar atendimento, planejar recursos capacitar profissionais essa condição.

Citations

0
Impact of COVID-19 on adverse reactions to subcutaneous specific immunotherapy in children:a retrospective cohort study DOI Creative Commons
Jingjing Li, Yanling Chen, Hong Ye

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 7, 2024

COVID-19 is a new infectious disease. To investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases the adverse reactions of subcutaneous specific immunotherapy (SCIT) in children. This study was conducted by collecting relevant data from children who underwent house dust mite SCIT April 3, 2021, to March 18, 2023, including information on time infection, symptoms, and after each allergen injection. A mixed effects model used analyze changes before infection. Among records 2658 injections 123 SCIT, overall reaction rate 39.8% 30.0% Compared with pre-infection COVID-19, risks reactions, local systemic were reduced (odds ratio [OR] = 0.24, 0.31, 0.28, all P < 0.05). incidence unvaccinated group highest (15.3% vs. 7.1%). The decreased 2-vaccinated recipients (OR 0.29–0.31, In children, SARS-CoV-2 does not increase SCIT. finding can provide basis for implementation allergen-specific (AIT) during pandemic.

Language: Английский

Citations

0