Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2481 - 2481
Published: Oct. 29, 2024
Glioblastoma is the most common and aggressive primary brain tumour, characterised by its invasive nature complex metabolic profile. Emerging research highlights role of amino acids (AAs) in glioblastoma metabolism, influencing tumour growth surrounding microenvironment.
Language: Английский
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
Background: Glioblastoma (GBM) and grade 4 astrocytoma (ASTROG4) are aggressive primary brain tumors characterized by rapid growth, invasiveness, poor prognosis, differentiated the presence or absence of isocitrate dehydrogenase (IDH) mutation according to World Health Organization (WHO) 2021 classification. Essential molecular markers, in addition IDH mutations, include alpha-thalassemia/mental retardation syndrome X-linked (ATRX) loss p53 expression, which significantly influence their classification prognosis. Pyruvate kinase M2 (PKM2), a critical enzyme tumor metabolism, has been implicated glioma progression, but its prognostic significance remains unclear. Methods: This prospective study aimed quantitatively measure PKM2 immunohistochemistry (IHC) expression GBM (IDH wildtype) versus ASTROG4 R132H mutant), assess correlation between prognosis these two patient groups, investigate ATRX relation levels. A total 67 patients with high-grade gliomas (43 GBM, 24 ASTROG4) were analyzed using IHC for IDH1, ATRX, p53, PKM2. was quantified 3DHISTECH (Budapest, Hungary) image analysis software, correlations clinical parameters, survival, other markers evaluated. Kaplan-Meier survival Cox regression models assessed impact factors on Results: observed both ASTROG4, no significant differences positivity rates. However, high intensity scores correlated increased mortality risk (p=0.041). ATRX-negative showed elevated levels, suggesting compensatory metabolic adaptations. cases had better outcomes than GBM. Severe preoperative motor deficits associated threefold increase risk, highlighting role determining Conclusions: plays an important metabolism can serve as potential therapeutic target. Its association highlights involvement progression genomic instability. Combining parameters improve accuracy inform personalized treatment strategies astrocytic tumors.
Language: Английский
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European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177343 - 177343
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 17, 2025
Abstract Glioblastoma is a highly malignant tumor of the central nervous system with high mortality rate. The mechanisms driving glioblastoma onset and progression are complex, posing substantial challenges for developing precise therapeutic interventions to improve patient survival. Over century ago, discovery Warburg effect underscored importance abnormal glycolysis in tumors, marking pivotal moment cancer research. Subsequent studies have identified mitochondrial energy conversion as fundamental driver growth. Recently, lipid metabolism has emerged critical factor cell survival, providing an alternative source. Research shown that reprogrammed glioblastoma, playing vital role shaping biological behavior cells. In this review, we aim elucidate impact on tumorigenesis explore potential targets. Additionally, provide insights into regulatory govern metabolism, emphasizing roles key genes regulators involved essential metabolic process.
Language: Английский
Citations
0
Published: March 19, 2025
胶质母细胞瘤是一种棘手的神经系统恶性肿瘤，由于其较高的侵袭性、异质性、代谢率，患者中位生存期通常只有12~15个月。在胶质瘤中，肿瘤相关巨噬细胞甚至占到30%~50%,先前研究表明，巨噬细胞极化为M1表型巨噬细胞 （经典激活巨噬细胞）和M2表型巨噬细胞 （替代激活巨噬细胞）。后者多具有促进肿瘤生长的作用。通过加入细胞因子改变肿瘤微环境，促进M2型肿瘤相关巨噬细胞向M1型巨噬细胞转化是当前治疗的一种策略。近年研究发现肿瘤细胞和微环境通过调控基因信号通路参与巨噬细胞向M2型极化的过程。处于不同的微环境下巨噬细胞的行为和物质代谢得以揭示，临床试验也取得许多进展，运用纳米技术作为药物载体来进入到传统手术无法切除的游离肿瘤细胞,基因编辑肿瘤细胞，采用光动力疗法传递药物，靶向治疗的基础上采用多种方法联合治疗，从而延长患者生存期。文章综述了M2巨噬细胞在胶质瘤中的代谢机制，并分析相关临床研究，为今后基础研究和临床治疗提供方向。
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Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 28, 2025
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by rapid proliferation, extensive infiltration, significant intratumoral heterogeneity. Despite advancements conventional treatments, including surgery, radiotherapy, chemotherapy, prognosis for GBM patients remains poor, with a median survival of approximately 15 months. Immunotherapy has emerged as promising alternative; however, unique biological immunological features, its immunosuppressive microenvironment (TME) low mutational burden, render it resistant to many immunotherapeutic strategies. This review explores key challenges immunotherapy, focusing on immune evasion mechanisms, blood-brain barrier (BBB), TME. Immune checkpoint inhibitors CAR-T cells have shown promise preclinical models but limited clinical success due antigen heterogeneity, cell exhaustion, impaired trafficking across BBB. Emerging strategies, dual-targeting cells, engineered secreting therapeutic molecules, advanced delivery systems overcome BBB, show potential enhancing treatment efficacy. Addressing these crucial improving immunotherapy outcomes.
Language: Английский
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Methods and protocols in food science, Journal Year: 2025, Volume and Issue: unknown, P. 99 - 111
Published: Jan. 1, 2025
Language: Английский
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Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(5)
Published: May 1, 2025
ABSTRACT Biological systems do not exist in isolation. Analogous to the intricate design of a spider web, metabolic adaptations propagated by glioblastoma cells are interlaced, creating “defense mechanism” that increases likelihood mutagenesis and proliferation, while mitigating stress‐induced tumor cell death immune evasion. Previous studies have observed role cardiolipin (CL) electron transport chain (ETC) function several other intracellular signaling pathways. Our review provides synopsis existing knowledge about CL its complex relationship with reprogramming at subcellular level. Through meticulous examination defects due biogenesis modifications, we seek elucidate multifaceted connections between aberrant variants alterations underlie progression. A comprehensive grasp these mechanisms could provide future direction designing chemotherapeutic agents selectively target glioblastoma, less harmful normal cells, therefore, may extend patient survival.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2481 - 2481
Published: Oct. 29, 2024
Glioblastoma is the most common and aggressive primary brain tumour, characterised by its invasive nature complex metabolic profile. Emerging research highlights role of amino acids (AAs) in glioblastoma metabolism, influencing tumour growth surrounding microenvironment.
Language: Английский
Citations
1