Regenerative medicine reports ., Journal Year: 2024, Volume and Issue: 1(2), P. 172 - 186
Published: Dec. 1, 2024
The epidermal growth factor receptor (signaling pathway is involved in numerous important mammal cell functions, such as growth, survival, proliferation, and differentiation. Associated with this, it tissue normal development tumorigenesis, repair. Epidermal broadly expressed the organism, including central peripheral nervous system, where has neurotrophic functions. system a limited capacity for regeneration upon lesion, leading to severe disabilities, blindness, sensorimotor deficits, paralysis. However, observations suggest that its innate neurogenic response may be amplified promote replenishment of damaged neuronal populations. In addition, environment can also modulated regeneration. Therefore, pathways neural repair have been investigated terms regenerative medicine, discover new therapies recover from traumatic injury or ischemia inhibit progression neurodegenerative diseases. Growth factors widely accepted most promoters proliferation neurogenesis under physiologic conditions after injury. this review, we summarize how signaling damage neurodegeneration several settings, olfactory epithelium, brain, spinal cord, optic nerve, context medicine and, therefore, neurological function reestablishment insults.
Language: Английский