Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Nov. 15, 2024
The
treatment
of
cancer
has
become
a
profoundly
intricate
procedure.
Traditional
methods,
including
chemotherapy,
surgery
and
radiotherapy,
have
been
utilized,
while
notable
progress
achieved
in
recent
years.
Among
targeted
therapies
for
cancer,
folic
acid
(FA)
conjugated
metal-based
nanoparticles
(NP)
emerged
as
an
innovative
strategy,
namely
photodynamic
therapy
(PDT)
photothermal
(PTT).
These
NP
exploit
the
strong
attraction
between
FA
folate
receptors,
which
are
excessively
produced
several
cells,
order
to
enable
precise
administration
improved
effectiveness
treatment.
During
PDT,
functionalized
with
used
photosensitizers
activated
by
light,
produce
reactive
oxygen
species
that
cause
cells
undergo
apoptosis.
Within
framework
PTT,
these
effectively
transform
light
energy
into
concentrated
heat,
specifically
targeting
destroying
tumor
cells.
This
review
examines
fundamental
mechanisms
improve
PDT
PTT
simultaneously
presenting
important
findings
demonstrate
FA-functionalized
MNP
laboratory
animal
models.
In
addition,
paper
also
discusses
problems
potential
directions
their
clinical
translation.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5855 - 5855
Published: Dec. 11, 2024
Cancer
immunotherapy
using
immune
checkpoint
blockades
has
emerged
as
a
promising
therapeutic
approach.
However,
faces
challenges
such
low
response
rates
in
solid
tumors,
necessitating
strategies
to
remodel
the
immune-suppressive
tumor
microenvironment
(TME)
into
an
immune-activated
state.
One
of
primary
approaches
achieve
this
transformation
is
through
induction
immunogenic
cell
death
(ICD).
Herein,
we
discussed
maximize
ICD
nanoparticles.
In
particular,
review
highlighted
various
studies
integrating
chemotherapy,
radiation
therapy
(RT),
photodynamic
(PDT),
and
photothermal
(PTT)
with
nanoparticle-based
immunotherapy.
The
research
covered
aims
provide
valuable
insights
for
future
on
nanoparticle-assisted
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Nov. 15, 2024
The
treatment
of
cancer
has
become
a
profoundly
intricate
procedure.
Traditional
methods,
including
chemotherapy,
surgery
and
radiotherapy,
have
been
utilized,
while
notable
progress
achieved
in
recent
years.
Among
targeted
therapies
for
cancer,
folic
acid
(FA)
conjugated
metal-based
nanoparticles
(NP)
emerged
as
an
innovative
strategy,
namely
photodynamic
therapy
(PDT)
photothermal
(PTT).
These
NP
exploit
the
strong
attraction
between
FA
folate
receptors,
which
are
excessively
produced
several
cells,
order
to
enable
precise
administration
improved
effectiveness
treatment.
During
PDT,
functionalized
with
used
photosensitizers
activated
by
light,
produce
reactive
oxygen
species
that
cause
cells
undergo
apoptosis.
Within
framework
PTT,
these
effectively
transform
light
energy
into
concentrated
heat,
specifically
targeting
destroying
tumor
cells.
This
review
examines
fundamental
mechanisms
improve
PDT
PTT
simultaneously
presenting
important
findings
demonstrate
FA-functionalized
MNP
laboratory
animal
models.
In
addition,
paper
also
discusses
problems
potential
directions
their
clinical
translation.
