Harnessing Cannabis sativa Oil for Enhanced Skin Wound Healing: The Role of Reactive Oxygen Species Regulation

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1277 - 1277

Published: Sept. 30, 2024

emerges as a noteworthy candidate for its medicinal potential, particularly in wound healing. This review article explores the efficacy of cannabis oil reducing reactive oxygen species (ROS) during healing acute and chronic wounds, comparing it to standard treatments. ROS, produced from various internal external sources, play crucial role development by causing cell tissue damage. Understanding ROS on skin wounds is essential, they act both signaling molecules contributors oxidative Cannabis oil, recognized antioxidant properties, may help mitigate damage scavenging upregulating antioxidative mechanisms, potentially enhancing emphasizes ongoing research future potential dermatological treatments, highlighted through clinical studies patent updates. Despite promising benefits, optimizing formulations therapeutic applications remains challenge, underscoring need further realize capabilities wounds.

Language: Английский

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Cannabinoids as Potential Multitargeting Neuroprotectants in Neuropathic Pain: Exploring the Interplay between Cannabinoid System and Autophagy

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The dysregulation of autophagy plays a significant role in the onset various pathologies, with emerging evidence indicating its potential involvement chronic pain conditions. cellular and molecular mechanisms underlying this pathology have been thoroughly investigated, endocannabinoid system (ECS) identified as crucial factor progression neuropathic pain. This chapter highlights several plant-derived cannabinoids, including cannabidiol, cannabinol, Δ-9-tetrahydrocannabinol, which exhibit unique modulatory effects on ECS. We discuss roles cannabinoid receptors, enzymes, PPARγ modulators decreased levels inflammatory cytokines, well reduction microglial activation, inhibit assembly NLRP3 inflammasome complex, potentially provides substantial neuroprotective Since discovery implications mitochondrial dysfunction impairment pain, there has an increasing interest therapeutic system.

Language: Английский

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Integrating Sustainable Cultivation Practices and Advanced Extraction Methods for Improved Cannabis Yield and Cannabinoid Production

International Journal of Plant Biology, Journal Year: 2025, Volume and Issue: 16(2), P. 38 - 38

Published: March 21, 2025

The rising global demand for medicinal cannabis necessitates the optimization of cultivation, harvesting, and extraction techniques to maximize cannabinoid yield purity. This study investigates Foi Thong Phu Pha Yon strain under controlled environmental conditions, evaluating effects temperature, humidity, CO2 concentration, light exposure on plant growth biosynthesis. A total 170 seeds were germinated, with an 85% germination success rate, various strategies, including soil composition, nutrient application, irrigation methods, tested determine most effective approach. research findings indicate that vegetative was optimal at 27 °C, 70% 1200 ppm while flowering required a reduced temperature (22 °C), lower humidity (50%), elevated levels (1900 ppm) enhance production prevent disease. Furthermore, harvest timing significantly influenced CBD yield, peak content observed when 80% trichomes cloudy white. Over two growing cycles, this produced 43,200 g fresh buds, resulting in 7560 dried buds. process, utilizing dynamic maceration 95% ethanol, followed by winterization chromatography, yielded 2343.60 extract, 589.68 CBD, average purity 86.599%. Advanced such as flash chromatography distillation further refined isolate, ensuring pharmaceutical-grade quality. These highlight effectiveness precise control, strategic advanced methodologies optimizing production. provides valuable insights agricultural researchers, policymakers, pharmaceutical industry, supporting sustainable cultivation practices improved product quality expanding market.

Language: Английский

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Functionality of Alternative Flours as Additives Enriching Bread with Proteins

Agriculture, Journal Year: 2025, Volume and Issue: 15(8), P. 851 - 851

Published: April 15, 2025

Legume cultivation is important for a wide array of reasons, including its positive effects on the environment, economy, and human health. Legumes have different amino acid profiles that complement those three globally most staple foods (rice, corn, wheat). Therefore, aim this work was to assess functionality legume flours (as well as hemp an emerging protein source) enriching supplements in breadmaking. The research focused both nutritional sensory evaluation flour with assistance novel techniques such diffusing wave spectroscopy static multiple light scattering. value yellow green peas chickpeas comparable, noticeable difference being total fiber content, ranged between 6.8 9.7 g/100 g flour. Hemp outclassed all terms content fiber, which over quadrupled. However, it associated cost worse technological properties. Addition investigated increased dough stability, proved by scattering reduction Turbiscan Stability Index. Microrheology improved only addition pea flour, manifested increase macroscopic viscosity index decrease fluidity index. This had also beneficial properties bread quality, texture perception, appearance, taste, overall acceptance.

Language: Английский

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Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils

Fitoterapia, Journal Year: 2024, Volume and Issue: 177, P. 106128 - 106128

Published: July 24, 2024

Language: Английский

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O uso terapêutico da Cannabis e seus derivados no tratamento de doenças neurodegenerativas

Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(4), P. e71708 - e71708

Published: Aug. 6, 2024

Introdução: Dentre as principais DNs pode-se citar a Doença de Alzheimer, Parkinson, Coreia Huntington, Esclerose Múltipla e Lateral Amiotrófica, todas elas progressivas relacionadas à idade fatores risco como nutrição, infecção, stress oxidativo associadas perda e/ou disfunção neurônios em diferentes regiões do encéfalo. Assim, com milhões pessoas sendo afetadas declínio cognitivo, motora outros sinais sintomas neurológicos, o manejo das doenças esboça um impacto direto no bem-estar dos pacientes seus familiares, constando grande fardo social, salutar econômico, uma vez que exige ampla necessidade cuidados paliativos. À vista disso, diversos estudos foram conduzidos nas últimas décadas acerca uso canabinóides sua relação fitoterapia. Objetivo: Este estudo tem objetivo principal realizar análise atuais sobre Cannabis derivados na terapêutica amplo leque neurodegenerativas, fim verificar real eficácia nível segurança. Métodos: Foi realizada busca bases dados MEDLINE, LILACS SciELO. Na fase identificação, utilizando-se os descritores, encontrados 76 artigos, não duplicados. Sendo assim, tendo base critérios inclusão, filtrados artigos publicados entre Janeiro 2014 Julho 2024, totalizando 66 artigos. Ainda elegibilidade, verificando tema focal da pesquisa, foi excluído 1 artigo estava incompleto. Ao final, selecionados 65 científicos revisões literatura relatos pesquisa. Discussão:Apesar promessas terapêuticas derivados, pesquisa aplicação neurodegenerativas ainda enfrenta várias limitações precisam ser abordadas para consolidar seu clínico. Uma preocupações é variabilidade dosagem formulação produtos utilizados nos estudos, dificulta comparação direta resultados. Além legislação medicinal varia significativamente países, impactando disponibilidade aceitação desses tratamentos. Ademais, maioria ensaios clínicos realizados até agora apresenta tamanhos amostra pequenos períodos acompanhamento relativamente curtos, limita capacidade generalizar achados avaliar efeitos longo prazo. A heterogeneidade desenhos populações também contribui inconsistência É essencial tratamentos sejam acompanhados perto por profissionais saúde garantir benefícios superem riscos, crucial continuar investigação entender completamente mecanismos ação, riscos associados, garantindo baseados evidências robustas seguras. Conclusão: Nota-se mais tema, realização bem projetados grandes amostras prazo, validar preliminares fornecer segurança neurodegenerativas.

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