Circulating growth differentiation factor-15 concentration and hypertension risk: a dose-response meta-analysis DOI Creative Commons
Zhengqing Yu,

Jianshu Gao,

Zhongwei Zhou

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 30, 2025

Background Growing evidence suggests that growth differentiation factor-15 (GDF-15) may contribute to adverse clinical outcomes, such as major cardiovascular events and all-cause mortality. However, there is little information about its relationship hypertension. This meta-analysis aimed quantitatively evaluate the between circulating GDF-15 hypertension prevalence. Methods Databases searched included PubMed, Web of Science, Embase, from inception August 2024. The inclusion criteria were studies reporting prevalence in at least three categories. Result A total 24 21 articles with 35,904 participants 23,925 hypertensive cases this meta-analysis. Compared individuals a low level GDF-15, those high had higher [odds ratios (OR) 1.60, 95% confidence interval (CI) 1.37–1.88, P < 0.001). In dose-response meta-analysis, increased by 24% every 1 ng/ml increase (OR 1.24, CI 1.16–1.33, curve was nonlinear ( -nonlinearity 0.001), plateauing or even decreasing slightly after concentrations reached approximately 5.5 ng/ml. Significant heterogeneity detected pooled analysis meta-regression suggested participants’ age diabetes significantly accounted for heterogeneity. Conclusions Circulating positively non-linearly associated hypertension, plateau slight decline reaching certain dose. Systematic Review Registration: https://inplasy.com/inplasy-2023-3-0082/ , identifier (INPLASY202330082).

Language: Английский

Angiotensin II: A novel biomarker in vascular diseases DOI
Qinyi Zhou, Jing Pan, Wang Liu

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 568, P. 120154 - 120154

Published: Jan. 22, 2025

Language: Английский

Citations

1
Circulating growth differentiation factor-15 concentration and hypertension risk: a dose-response meta-analysis DOI Creative Commons
Zhengqing Yu,

Jianshu Gao,

Zhongwei Zhou

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 30, 2025

Background Growing evidence suggests that growth differentiation factor-15 (GDF-15) may contribute to adverse clinical outcomes, such as major cardiovascular events and all-cause mortality. However, there is little information about its relationship hypertension. This meta-analysis aimed quantitatively evaluate the between circulating GDF-15 hypertension prevalence. Methods Databases searched included PubMed, Web of Science, Embase, from inception August 2024. The inclusion criteria were studies reporting prevalence in at least three categories. Result A total 24 21 articles with 35,904 participants 23,925 hypertensive cases this meta-analysis. Compared individuals a low level GDF-15, those high had higher [odds ratios (OR) 1.60, 95% confidence interval (CI) 1.37–1.88, P < 0.001). In dose-response meta-analysis, increased by 24% every 1 ng/ml increase (OR 1.24, CI 1.16–1.33, curve was nonlinear ( -nonlinearity 0.001), plateauing or even decreasing slightly after concentrations reached approximately 5.5 ng/ml. Significant heterogeneity detected pooled analysis meta-regression suggested participants’ age diabetes significantly accounted for heterogeneity. Conclusions Circulating positively non-linearly associated hypertension, plateau slight decline reaching certain dose. Systematic Review Registration: https://inplasy.com/inplasy-2023-3-0082/ , identifier (INPLASY202330082).

Language: Английский

Citations

0