Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(12)

Published: Dec. 17, 2024

Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within local environment, TAMs may promote angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit progression via neoantigen presentation, tumoricidal reactive oxygen species generation pro-inflammatory cytokine secretion. Therefore, have a pivotal role in determining response to therapy. TAM phenotypes driven by cytokines physical produced cells, adipocytes, fibroblasts, pericytes, other TME. Research has shown can be primed environmental stimuli, adding another layer of complexity context determines phenotype. Innate priming is functional consequence metabolic epigenetic reprogramming primary stimulant, resulting altered cellular future secondary stimulation. offers novel target for development immunotherapy improved prognosis disease, but also raises risk exacerbating existing inflammatory pathologies. This review will discuss mechanisms underlying including modification, its relevance progression, possible clinical implications treatment.

Language: Английский