Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 15, 2024

Abstract Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia, defined as reduced oxygen availability, critical factor that influences aging through molecular pathways involving hypoxia‐inducible factors (HIFs), oxidative stress, inflammation, epigenetic modifications. This review explores interconnected roles hypoxia in aging, highlighting how hypoxic conditions exacerbate damage, promote senescence, contribute age‐related pathologies, including cardiovascular neurodegenerative disorders, cancer, metabolic dysfunctions, pulmonary conditions. By examining mechanisms linking we identify key serve potential therapeutic targets. Emerging interventions such HIF modulators, antioxidants, senolytics, lifestyle modifications hold promise mitigating adverse effects on tissues. However, challenges heterogeneity lack reliable biomarkers, safety concerns regarding hypoxia‐targeted therapies remain. emphasizes need for personalized approaches advanced technologies develop effective antiaging interventions. integrating current knowledge, this provides comprehensive framework underscores importance targeting hypoxia‐induced enhance healthy reduce burden diseases.

Language: Английский

---

Neonatal Hypoxia Induces Behavioral Deficit Associated with Impaired Glucocorticoid and Serotoninergic Systems in Adult Rats

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(5), P. 1677 - 1684

Published: Sept. 1, 2024

Language: Английский

---

Comparative Analysis of the Effects of Maternal Hypoxia and Placental Ischemia on HIF1-Dependent Metabolism and the Glucocorticoid System in the Embryonic and Newborn Rat Brain

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13342 - 13342

Published: Dec. 12, 2024

Prenatal hypoxia, often accompanied by maternal glucocorticoid stress, can predispose offspring to neurological disorders in adulthood. If placental ischemia (PI) primarily reduces fetal oxygen supply, the hypoxia (MH) model also elicits a pronounced exposure. Here, we compared MH and PI rats distinguish their unique overlapping effects on embryonic newborn brain development. We analyzed transport into developing brain, receptor (GR) expression, GR-dependent transcription, along with key enzymes regulating metabolism (MP) placentas (FP) brain. Additionally, examined hypoxia-inducible factor 1-alpha (HIF1α) its downstream genes, as well glycolysis pentose phosphate pathway, both associated of substrates essential for synthesis degradation. Both induced HIF1-dependent metabolic alterations, enhancing transiently disrupting redox homeostasis. However, only caused surge that altered early responsiveness. Over time, these differences may lead distinct long-term outcomes neuronal structure function. This work clarifies individual contributions hypoxic stresses development, suggesting combining models could provide valuable insights future investigations mechanisms underlying developmental pathologies, including non-heritable psychoneurological neurodegenerative disorders.

Language: Английский

---

Neonatal Hypoxia Induces Behavioral Deficit Associated with Impairment in the Glucocorticoid and Serotonergic Systems in Adult Rats

Журнал эволюционной биохимии и физиологии, Journal Year: 2024, Volume and Issue: 60(5), P. 535 - 543

Published: Dec. 13, 2024

Language: Английский

---