The Role of MicroRNAs in Progressive Supranuclear Palsy—A Systematic Review DOI Open Access

Aleksandra Ćwiklińska,

Grzegorz Procyk, Dariusz Koziorowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8243 - 8243

Published: July 28, 2024

Progressive supranuclear palsy (PSP) is a rare, neurodegenerative movement disorder. Together with multiple system atrophy (MSA), Dementia Lewy bodies (DLB), and corticobasal degeneration (CBD), PSP forms group of atypical parkinsonisms. The latest diagnostic criteria, published in 2017 by the Movement Disorders Society, classify diagnosis into defined, probable, possible categories based on clinical examination. However, no single test specific sensitive for this disease. Microribonucleic acids (miRNAs) are promising molecules, particularly case diseases that lack appropriate treatment tools, which supports exploring their role PSP. We aimed to systematically review current knowledge about miRNAs This study was registered Open Science Framework Registry, protocol available online. Primary original studies, both preclinical, written English assessing were included. Systematic reviews, meta-analyses, reports, letters editors, commentaries, conference abstracts, guidelines/statements, expert opinions, preprints, book chapters excluded. following five databases searched: Embase, Medline Ultimate, PubMed, Scopus, Web Science. Each database last searched 18 June 2024. Eventually, nine studies relevant discussed area risk bias not assessed. selected research suggests may be considered biomarkers exact involvement pathogenesis still determined. Several microRNAs found dysregulated patients applies brain tissue fluids like cerebrospinal fluid CSF or blood. could potentially helpful differentiating among patients, PD healthy individuals. Although some correlations alterations have already been found, field requires much more research. MicroRNAs exciting small investigation many diseases, including PSP, lead significant discoveries.

Language: Английский

MicroRNA signatures of VO2peak in older adult participants of the Study of Muscle, Mobility and Aging DOI Open Access
Genesio M. Karere, Fang‐Chi Hsu, Russell T. Hepple

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Peak oxygen consumption during exercise (VO 2 peak), is a direct measure of cardiorespiratory fitness (CF), key indicator physical function and overall health. However, the molecular changes that underpin VO peak variation are not clear. Our objective to understand miRNA signatures relate variation, which could provide insights novel mechanisms contribute low peak. We used small RNA sequencing analyze serum samples from 72 participants (70-79 yrs old, 53% female) Study Muscle, Mobility Aging (SOMMA). analyzed individuals with or high (N=18/group) as well 36 randomly selected spanning entire spectrum LIMMA analysis package for regression identify differentially expressed miRNAs. receiver operating characteristic curve evaluate Area Under Curve (AUC) sensitivity specificity rates. identified 1,055 miRNAs in all samples. Expression 65 differed between (p < 0.05). After p-value adjustment, expression 5 (miR-1301-3p, -431-5p, -501-5p, -519a-3p, -18a-3p) remained significantly different (FDR = The five had AUC ranging 0.77 0.84. optimal ranged 70 80% 80 90%, respectively. adjustment age sex covariates, 46 correlated 0.05) miR-519a-3p significant based on adjusted p-values. signature older might drive Future studies will validate findings larger, longitudinal study cohort.

Language: Английский

Citations

0
Regulating the expression of exercise-induced micro-RNAs and long non-coding RNAs: implications for controlling cardiovascular diseases and heart failure DOI Creative Commons
Guobiao Yang, Wanying Yang

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 20, 2025

The intricate interplay between physical training and non-coding RNAs, specifically microRNAs (miRNAs) long RNAs (lncRNAs), has attracted considerable attention in understanding physiological adaptations pathological conditions. Both miRNAs lncRNAs are essential modulators of gene expression, influencing various cellular processes, including those related to muscle metabolism, inflammation, recovery from injury. This review investigates the bifunctional role response training, highlighting their involvement hypertrophy, endurance adaptations, modulation inflammatory pathways. Additionally, we examine how conditions, such as cardiovascular disease, heart failure, can alter expression profiles lncRNAs, potentially disrupting beneficial effects training. crosstalk these under states underscores potential biomarkers for assessing responses therapeutic targets enhancing performance. Understanding interactions may pave way novel interventions optimize health outcomes through tailored programs.

Language: Английский

Citations

0
The Role of Alarmins in the Pathogenesis of Atherosclerosis and Myocardial Infarction DOI Creative Commons
Kajetan Kiełbowski, Patryk Skórka,

Paulina Plewa

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8995 - 9015

Published: Aug. 17, 2024

Atherosclerosis is a condition that associated with lipid accumulation in the arterial intima. Consequently, enlarging lesion, which also known as an atherosclerotic plaque, may close blood vessel lumen, thus leading to organ ischaemia. Furthermore, plaque rupture and initiate formation of thrombus, can cause acute background pathological eventually lead major cardiovascular diseases such coronary syndrome or ischaemic stroke. The disorder altered profile alarmins, stress response molecules are secreted due cell injury death induce inflammatory responses. High-mobility group box 1 (HMGB1), S100 proteins, interleukin-33, heat shock proteins (HSPs) affect behaviour endothelial cells vascular smooth muscle (VSMCs). Thus, alarmins control responses proliferation VSMCs, two important processes implicated pathogenesis atherosclerosis. In this review, we will discuss role pathophysiology atherosclerosis myocardial infarction.

Language: Английский

Citations

1
The Role of MicroRNAs in Progressive Supranuclear Palsy—A Systematic Review DOI Open Access

Aleksandra Ćwiklińska,

Grzegorz Procyk, Dariusz Koziorowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8243 - 8243

Published: July 28, 2024

Progressive supranuclear palsy (PSP) is a rare, neurodegenerative movement disorder. Together with multiple system atrophy (MSA), Dementia Lewy bodies (DLB), and corticobasal degeneration (CBD), PSP forms group of atypical parkinsonisms. The latest diagnostic criteria, published in 2017 by the Movement Disorders Society, classify diagnosis into defined, probable, possible categories based on clinical examination. However, no single test specific sensitive for this disease. Microribonucleic acids (miRNAs) are promising molecules, particularly case diseases that lack appropriate treatment tools, which supports exploring their role PSP. We aimed to systematically review current knowledge about miRNAs This study was registered Open Science Framework Registry, protocol available online. Primary original studies, both preclinical, written English assessing were included. Systematic reviews, meta-analyses, reports, letters editors, commentaries, conference abstracts, guidelines/statements, expert opinions, preprints, book chapters excluded. following five databases searched: Embase, Medline Ultimate, PubMed, Scopus, Web Science. Each database last searched 18 June 2024. Eventually, nine studies relevant discussed area risk bias not assessed. selected research suggests may be considered biomarkers exact involvement pathogenesis still determined. Several microRNAs found dysregulated patients applies brain tissue fluids like cerebrospinal fluid CSF or blood. could potentially helpful differentiating among patients, PD healthy individuals. Although some correlations alterations have already been found, field requires much more research. MicroRNAs exciting small investigation many diseases, including PSP, lead significant discoveries.

Language: Английский

Citations

0