Whole-Genome Resequencing Analysis of the Camelus bactrianus (Bactrian Camel) Genome Identifies Mutations and Genes Affecting Milk Production Traits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7836 - 7836

Published: July 17, 2024

Milk production is an important trait that influences the economic value of camels. However, genetic regulatory mechanisms underlying milk in camels have not yet been elucidated. We aimed to identify candidate molecular markers affect camel production. classified Junggar Bactrian (9–10-year-old) as low-yield (<1.96 kg/d) or high-yield (>2.75 based on performance. fat (5.16 ± 0.51 g/100 g) and protein (3.59 0.22 concentrations were significantly lower high-yielding than those low-yielding (6.21 0.59 g, 3.93 0.27 respectively) (p < 0.01). There no apparent differences gland tissue morphology between low- high-production groups. Whole-genome resequencing 12 was performed. The results selection mapping methods, performed using two methods (FST θπ), showed 264 single nucleotide polymorphism sites (SNPs) overlapped identifying 181 genes. These genes mainly associated with regulation oxytocin, estrogen, ErbB, Wnt, mTOR, PI3K-Akt, growth hormone synthesis/secretion/action, MAPK signaling pathways. A total 123 SNPs selected, genomic regions pathways for SNP genotyping, verification 521 additional This analysis 13 yield 18 composition percentages. Most these located coding genome. five mutation found introns CSN2 (β-casein) CSN3 (κ-casein), respectively. Among genes, NR4A1, ADCY8, PPARG, CSN2, previously well studied dairy livestock. observations provide a basis understanding breeding programs at improving

Language: Английский

Genetic diversity and footprint of the Ethiopian cattle population, and the application of molecular information on sustainable cattle genetic improvement: Opportunities, challenges, and future directions in Ethiopia. A comprehensive review

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Ethiopia has over 70 million cattle, and about 97.4% of the total cattle in country are local breeds. The remaining hybrid exotic breeds, which account for 2.3% 0.31%, respectively. genetic diversity genomic footprint Ethiopian populations represent a valuable reservoir biodiversity with profound implications sustainable agriculture food security. application molecular information breeding improvement presents significant opportunities Ethiopia's livestock sector. review explores diversity, footprint, potential benefits, challenges, future directions associated integrating technologies into programs country. Molecular tools, such as genomics marker‐assisted selection, enable identification utilization variation related to desirable traits, including productivity, disease resistance, adaptation changing climatic conditions. By utilizing these breeders can accelerate progress, enhance resilience climate change, improve overall productivity. However, several challenges must be addressed effectively harness benefits technologies. These include limited infrastructure resources research, inadequate data on genetics performance, need capacity building among stakeholders involved programs. incorporating markers important identify superior animals at an early age, accelerating progress within population. Integration this technology traditional practices selection signatures lead more effective strategies. In conclusion, offers promising investing collaborations, implementing comprehensive programs, full

Language: Английский