Interconnection of CD133 Stem Cell Marker with Autophagy and Apoptosis in Colorectal Cancer DOI Creative Commons
Ferenc Sípos, Györgyi Műzes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11201 - 11201

Published: Oct. 18, 2024

CD133 protein expression is observable in differentiated cells, stem and progenitor cells within normal tissues, as well tumor including colorectal cancer cells. The the predominant cell surface marker utilized to detect exhibiting cell-like characteristics. alters common abnormal processes cancer, such phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) Wnt/β-catenin pathways. Autophagy a cellular self-digestion mechanism that preserves intracellular milieu plays dual regulatory role cancer. In apoptosis critical death can impede progression. modulate autophagy via several signaling pathways; hence, it involved regulation of these intricate processes. This be an explanation for why associated with enhanced self-renewal, migration, invasion, survival under stress conditions purpose this review article explain complex relationship between protein, apoptosis, autophagy. We also want highlight possible ways CD133-mediated may affect Targeting aforementioned mechanisms have significant therapeutic eliminating CD133-positive cell-phenotype which responsible recurrence.

Language: Английский

An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update DOI Creative Commons
Susmita Roy, Dikshita Deka, K. Suresh Babu

et al.

Epigenetics, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 16, 2025

Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes critical role of epigenetic mechanisms its pathogenesis and progression. This also describes potential natural compounds altering landscape, focused mainly on DNA methylation, histone modification, non-coding RNAs. Publications from previous five years were searched retrieved using well-known search engines databases like PubMed, Google Scholar, ScienceDirect. Keywords CRC/colorectal cancer, CAC/Colitis associated inflammasomes, modulation, genistein, curcumin, quercetin, resveratrol, anthocyanins, sulforaphane, epigallocatechin-3-gallate used combinations during search. These predominantly affect pathways such as Wnt/β-catenin, NF-κB, PI3K/AKT suppress CRC cell proliferation oxidative stress enhance anti-inflammation apoptosis. However, their clinical use is restricted due low bioavailability. multiple methods exist overcome challenges this, including but not limited structural modifications, nanoparticle encapsulations, bio-enhancers, novel advanced delivery systems. improve supportive therapies that target progression epigenetically with fewer side effects. Current research focuses enhancing targeting control while minimizing effects, emphasizing improved specificity, bioavailability, efficacy standalone or synergistic therapies.

Language: Английский

Citations

0
Interconnection of CD133 Stem Cell Marker with Autophagy and Apoptosis in Colorectal Cancer DOI Creative Commons
Ferenc Sípos, Györgyi Műzes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11201 - 11201

Published: Oct. 18, 2024

CD133 protein expression is observable in differentiated cells, stem and progenitor cells within normal tissues, as well tumor including colorectal cancer cells. The the predominant cell surface marker utilized to detect exhibiting cell-like characteristics. alters common abnormal processes cancer, such phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) Wnt/β-catenin pathways. Autophagy a cellular self-digestion mechanism that preserves intracellular milieu plays dual regulatory role cancer. In apoptosis critical death can impede progression. modulate autophagy via several signaling pathways; hence, it involved regulation of these intricate processes. This be an explanation for why associated with enhanced self-renewal, migration, invasion, survival under stress conditions purpose this review article explain complex relationship between protein, apoptosis, autophagy. We also want highlight possible ways CD133-mediated may affect Targeting aforementioned mechanisms have significant therapeutic eliminating CD133-positive cell-phenotype which responsible recurrence.

Language: Английский

Citations

0