High-Fat Diet—Shared Environmental Risk Factor for Amyotrophic Lateral Sclerosis and Multiple Sclerosis

Sclerosis, Journal Year: 2025, Volume and Issue: 3(1), P. 1 - 1

Published: Jan. 12, 2025

Background: Amyotrophic lateral sclerosis (ALS) and multiple (MS) are, in essence, neurodegenerative disorders with significant individual, social, economic burdens worldwide. Despite having different clinical onset evolution, the two diseases share common risk factors underlying pathophysiological mechanisms. Environmental are particularly interesting, considering available effective counter strategies. High-fat diets remain a element that negatively impacts evolution of several disorders, including ALS MS. Focusing on changeable disease-related aspects is increasingly appealing context lack an treatment. Methods: This review aims to offer updated overview influence high-fat modulating progression MS, based search three relevant online databases. Results: In first part, shared mechanisms MS shown, differences between highlighted. Subsequently, most research this topic conducted animal models humans presented, bringing additional proof critical role neurodegeneration. Finally, current knowledge, authors potential therapeutic approaches future directions better control nutrition patients, hoping increase survival quality life. Conclusions: impact

Language: Английский

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Antioxidant Therapies in the Treatment of Multiple Sclerosis

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1266 - 1266

Published: Oct. 8, 2024

Several studies have proposed a potential role for oxidative stress in the development of multiple sclerosis (MS). For this reason, it seems tentative to think that treatment with antioxidant substances could be useful disease. In narrative review, we provide summary current findings on treatments, both experimental models MS, especially autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination model, clinical trials patients diagnosed MS. Practically all antioxidants tested MS shown improvement parameters, delaying evolution disease, improving histological biochemical including decreased levels markers inflammation central nervous system other tissues. Only few been carried out investigate efficacy most them short term involving series patients, so results these should considered inconclusive. regard, would desirable design long-term, randomized, multicenter long assessing several demonstrated

Language: Английский

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Protective Role of High-Density Lipoprotein in Multiple Sclerosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1276 - 1276

Published: Oct. 23, 2024

Multiple sclerosis (MS) is a chronic, progressive demyelinating disease with most likely autoimmune background and neurodegenerative component. Besides the process caused by autoreactive antibodies, an increased permeability in blood-brain barrier (BBB) also plays key role. Recently, there has been growing interest assessing lipid profile alterations patients MS. As result of myelin destruction, increase level cholesterol released from cells, which turn causes disruptions metabolism homeostasis both central nervous system (CNS) peripheral tissues. Currently, body evidence suggesting protective role HDL MS through its effect on BBB decreasing permeability. This follows impact endothelium anti-inflammatory effect, mostly interacting adhesion molecules like vascular cell molecule 1 (VCAM-1), intercellular (ICAM-1), E-selectin. HDL, action via sphingosine-1-phosphate, exerts inhibitory leukocyte migration, antioxidant properties contribute to improvement function. In this review, we want summarize these studies focus as mediator response

Language: Английский

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Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1681 - 1681

Published: Dec. 13, 2024

Background/Objectives: Centella asiatica (L.) Urban (family Apiaceae) (C. asiatica) is a traditional botanical medicine used in aging and dementia. Water extracts of C. (CAW) have been to treat neuropsychiatric symptoms related animal models are associated with increases antioxidant response element (ARE) genes improvements mitochondrial respiratory function neuronal health. Because multiple sclerosis (MS) shares its neurogenerative pathology oxidative stress dysfunction dementia, MS may also benefit from asiatica. To determine whether CAW similarly benefits symptoms, ARE gene expression, respiration inflammatory MS, the effects on clinical disability inflammation, we tested using experimental autoimmune encephalomyelitis (EAE). Methods: C57BL/6J mice induced EAE were treated or placebo for 2 weeks. The outcomes disability, signs anxiety (open field test), respiration, inflammation demyelination. Results: At dosing schedule concentrations tested, CAW-treated demonstrated increased expression activity compared those placebo-treated EAE. was reduced infiltrates spinal cord, but differences between populations activated versus quiescent microglia equivocal. did not improve behavioral performance, motor Conclusions: In model demonstrates similar neuroprotective it exhibits dementia mouse models. These benefits, along anti-inflammatory CAW, support further investigation people MS.

Language: Английский

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