Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with complex pathophysiological mechanisms such as oxidative stress, inflammation, apoptosis, and endothelial dysfunction driving progression. MicroRNAs (miRNAs), a class non-coding RNAs, have emerged key regulators gene expression involved in these processes, positioning them potential biomarkers therapeutic targets CVD management. Simultaneously, flavonoids, naturally occurring polyphenolic compounds found various plant-based foods, gained attention for their cardioprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. Recent studies suggest novel intersection between flavonoids miRNAs, where may modulate specific miRNAs implicated pathogenesis. This review explores miRNA modulators, focusing on ability to regulate associated cardiac fibrosis, hypertrophy, vascular inflammation. By bridging targeting, this highlights innovative pathways advancing treatment strategies. Additionally, preclinical clinical evidence supporting interactions is discussed, alongside challenges opportunities developing flavonoid-based therapies. Unlocking synergy could pave way more effective, personalized approaches management, addressing unmet needs contemporary cardiovascular care.

Language: Английский

Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Atherosclerosis, the primary cause of coronary artery disease (CAD), remains a leading global mortality. It is characterized by accumulation cholesterol-rich plaques and inflammation, which narrow arteries increase risk rupture. To elucidate this complex biological process improve therapeutic strategies, CAD has been extensively explored from an epigenetic perspective over past two decades. Epigenetics field investigating heritable alterations in gene expression without DNA sequence changes, such as methylation, histone modifications, non-coding RNAs. Increasing evidence indicated that development significantly influenced changes. Meanwhile, impact epigenetics now transitioning pathophysiology to therapeutics. Focusing on key enzymes their target genes will help facilitate diagnosis treatment CAD. This review synthesizes novel insights into CAD, addressing pathological processes, molecular mechanisms, potential biomarkers. Furthermore, we discuss emerging strategies targeting pathways. By focusing pivotal associated genes, work aims advance diagnostics interventions.

Language: Английский

MiR-568-5p, the key regulator of suppressor of cytokine signaling 4 (SOCS4) in the coronary artery disease

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 22, 2025

Language: Английский