Exploring Potential Complement Modulation Strategies for Ischemia–Reperfusion Injury in Kidney Transplantation
Dario Troise,
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Costanza Allegra,
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Luciana Antonia Cirolla
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et al.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 66 - 66
Published: Jan. 8, 2025
The
complement
system
plays
a
crucial
role
in
regulating
the
inflammatory
responses
kidney
transplantation,
potentially
contributing
to
early
decline
function.
Ischemia-reperfusion
injury
(IRI)
is
among
factors
affecting
graft
outcomes
and
primary
contributor
delayed
Complement
activation,
particularly
alternative
pathway,
participates
pathogenesis
of
IRI,
involving
all
compartments.
In
particular,
tubular
epithelial
cells
often
acquire
dysfunctional
phenotype
that
can
exacerbate
activation
damage.
Currently,
complement-modulating
drugs
are
under
investigation
for
treatment
diseases.
Many
these
have
shown
potential
therapeutic
benefits,
but
no
effective
clinical
treatments
renal
IRI
been
identified
yet.
this
review,
we
will
explore
target
factors,
receptors,
regulatory
proteins,
aiming
highlight
their
value
improving
management
IRI.
Language: Английский
Kidney Transplantation in Children and Adolescents With C3 Glomerulopathy or Immune Complex Membranoproliferative Glomerulonephritis: An International Survey of Current Practice
Pediatric Transplantation,
Journal Year:
2025,
Volume and Issue:
29(2)
Published: Feb. 24, 2025
Approximately
50%
of
patients
with
chronic
kidney
disease
due
to
C3
glomerulopathy
(C3G)
or
primary
immune-complex
membranoproliferative
glomerulonephritis
(IC-MPGN)
will
require
dialysis
and/or
transplantation
(KTx)
within
the
first
10
years
onset.
Currently,
there
are
no
guidelines
regarding
indications
for
KTx
post-transplant
management.
We
therefore
initiated
an
international
online
survey
via
Survey
Monkey
on
C3G
and
IC-MPGN
in
children
CKD
stage
5.
All
centers
European
Society
Paediatric
Nephrology
(ESPN)
were
invited
participate
survey,
which
was
conducted
from
August
23
November
25,
2023.
Sixty-five
(63%)
(n
=
103)
participated.
Twenty-six
percent
had
made
at
least
one
decision
against
living
donation
a
child
IC-MPGN.
The
main
reason
88.2%
these
decisions
concern
about
recurrence
underlying
any
potential
transplant.
Eighty-eight
indicated
deceased
as
option;
12%
decided
not
proceed
all.
Regarding
decision-making
management,
none
them
referred
existing
recommendation
by
national
regional
guideline.
For
post-transplant,
eculizumab
treatment
suggested
60%
respondents.
This
shows
considerable
reluctance
pediatric
nephrologists
list
5
donor
transplantation.
is
mainly
based
fear
combined
lack
reliable
options.
limited
access
affected
best
option
failure
requires
further
action.
Language: Английский
Complement-Mediated Kidney Disease and Living Donor Transplantation: Tailoring Approaches to Improve Outcomes
Current Transplantation Reports,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: April 16, 2025
Language: Английский
What is new in the pathogenesis and treatment of IgA glomerulonephritis
World Journal of Nephrology,
Journal Year:
2024,
Volume and Issue:
13(4)
Published: Nov. 6, 2024
Recently,
new
findings
have
been
clarified
concerning
both
pathogenesis
and
treatment
of
IgA
nephritis.
The
four
hits
theory
has
confirmed
but
several
genetic
wide
association
studies
allowed
finding
genes
connected
with
the
disease.
All
these
apply
to
each
hits.
Additionally,
discoveries
microbiota
its
connection
immune
system
generation
out
role
mucosa
in
nephropathy
pathogenesis.
is
also
changed
included
future
possibilities.
chronic
kidney
disease,
associated
nephropathy,
mandatory,
since
beginning
classical
immunosuppressive
agents
poor
effect.
corticosteroids
remain
an
important
cornerstone
any
phase
More
effect
related
B
cells
plasma
cells.
In
particular,
very
recent
documented
efficacy
anti
cell-activating
factor
A
proliferation-inducing
ligand
agents.
Most
are
date
II/III.
Finally,
targeting
complement
arising.
These
still
randomized
trials
act
principally
hit
4
where
immunocomplexes
mesangium
activate
different
pathways
cascade.
Language: Английский
Complement Activation in Kidney Transplantation
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 30, 2024
Kidney
transplantation
is
a
life-saving
procedure
for
individuals
with
end-stage
renal
disease,
yet
the
process
of
can
trigger
activation
complement
system,
critical
component
body’s
immune
response.
This
lead
to
adverse
outcomes,
including
acute
and
chronic
rejection
graft,
thereby
complicating
patient
management
graft
survival.
Furthermore,
interplay
between
immunosuppressive
therapies
remains
key
area
research,
as
prolonged
immunosuppression
may
enhance
risk
complications
while
failing
adequately
control
response
against
transplanted
organ,
necessitating
balance
these
factors
optimize
transplant
outcomes.
In
recent
years,
advances
in
understanding
mechanisms
have
led
exploration
novel
therapeutic
strategies
aimed
at
minimizing
damage
enhancing
its
long-term
functionality,
emphasizing
need
tailored
regimens
mitigate
associated
risks
improve
overall
success
kidney
transplantation.
Language: Английский